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01-02-2004 | Case Report

Mucosa-associated lymphoid tissue lymphoma in the conjunctiva of a child

Authors: Markus Tiemann, Steffi Häring, Marcus Heidemann, Jan Reichelt, Alexander Claviez

Published in: Virchows Archiv | Issue 2/2004

Abstract

Marginal zone lymphoma of the mucosa-associated lymphoid tissue (MALT) occurring in the conjunctiva has yet not been described in pediatric patients. We present a case of a 10-year-old girl with a MALT lymphoma involving the conjunctiva. The tumor consisted of plasma cells and marginal zone cells with discrete epitheliotropism. Immunohistochemical studies revealed positivity for CD20 and cytoplasmic immunoglobulin λ light chain restriction. Polymerase chain reaction-based molecular analysis of the infiltrate showed a monoclonal rearrangement for the hypervariable complimentary determining region III immunoglobulin region; whereas, a polyclonal pattern was seen for the T-cell receptor γ chain. Extensive further examination, including molecular techniques, revealed that the lymphoma was restricted to the conjunctiva (stage IA) and was not associated with any specific infection. The patient was treated with surgery and additional local cryotherapy. After 15 months of follow-up, the patient remains in complete remission.

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Title: Mucosa-associated lymphoid tissue lymphoma in the conjunctiva of a child
Authors: Markus Tiemann
Steffi Häring
Marcus Heidemann
Jan Reichelt
Alexander Claviez
Publication date: 01-02-2004
Publisher: Springer-Verlag
Published in: Virchows Archiv / Issue 2/2004
Print ISSN: 0945-6317
Electronic ISSN: 1432-2307
DOI: https://doi.org/10.1007/s00428-003-0919-7

At a glance: The STEP trials

Springer Medicine

Mucosa-associated lymphoid tissue lymphoma in the conjunctiva of a child

Abstract

At a glance: The STEP trials

Springer Medicine

Abstract

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