Skip to main content
Top
Published in: Neurocritical Care 2/2016

01-04-2016 | Practical Pearl

Mucor Thrombus

Authors: E. L. Scharf, H. J. Cloft, E. Wijdicks

Published in: Neurocritical Care | Issue 2/2016

Login to get access

Abstract

Background

To describe a rare presentation of ischemic stroke secondary to angioinvasive mucormycosis and endovascular retrieval of mycotic thrombus with stenting of the compressed vessel.

Summary of Case

We report a case of angioinvasive mucormycosis that externally compressed and invaded the internal carotid artery causing ischemic cerebral infarction. A sample of the thrombus was obtained using a stent retriever. Subsequent pathological analysis was shown to be consistent with the diagnosis of angioinvasive mucormycosis. The thrombosed and compressed segment was recanalized with the deployment of a stent.

Conclusions

The endovascular placement of an expandable stent in the setting of angioinvasive mucormycosis restored good cerebral blood flow in a proximal internal carotid artery occlusion. The patient’s aphasia resolved following this intervention. Artifacts of CT angiography may result in the overestimation of acute arterial occlusions. Endovascular carotid stenting may be a palliative measure in the setting of angioinvasive rhino-cerebro-orbital mucormycosis.
Literature
1.
go back to reference Roden MM, Zaoutis TE, Buchanan WL, et al. Epidemiology and outcome of zygomycosis: a review of 929 reported cases. Clin Infect Dis. 2005;41:634–53.CrossRefPubMed Roden MM, Zaoutis TE, Buchanan WL, et al. Epidemiology and outcome of zygomycosis: a review of 929 reported cases. Clin Infect Dis. 2005;41:634–53.CrossRefPubMed
2.
go back to reference Anand VK, Alemar G, Griswold JA Jr. Intracranial complications of mucormycosis: an experimental model and clinical review. Laryngoscope. 1992;102:656–62.CrossRefPubMed Anand VK, Alemar G, Griswold JA Jr. Intracranial complications of mucormycosis: an experimental model and clinical review. Laryngoscope. 1992;102:656–62.CrossRefPubMed
3.
4.
go back to reference Anaissie EJ, Shikhani AH. Rhinocerebral mucormycosis with internal carotid occlusion: report of two cases and review of the literature. Laryngoscope. 1985;95:1107–13.CrossRefPubMed Anaissie EJ, Shikhani AH. Rhinocerebral mucormycosis with internal carotid occlusion: report of two cases and review of the literature. Laryngoscope. 1985;95:1107–13.CrossRefPubMed
5.
go back to reference Bae MS, Kim EJ, Lee KM, Choi WS. Rapidly progressive rhino-orbito-cerebral mucormycosis complicated with unilateral internal carotid artery occlusion: a case report. Neurointervention. 2012;7:45–9.CrossRefPubMedPubMedCentral Bae MS, Kim EJ, Lee KM, Choi WS. Rapidly progressive rhino-orbito-cerebral mucormycosis complicated with unilateral internal carotid artery occlusion: a case report. Neurointervention. 2012;7:45–9.CrossRefPubMedPubMedCentral
6.
go back to reference Delbrouck C, Jacobs F, Fernandez Aguilar S, Devroede B, Choufani G, Hassid S. Carotid artery occlusion due to fulminant rhinocerebral mucormycosis. Acta Otorhinolaryngol Belg. 2004;58:135–40.PubMed Delbrouck C, Jacobs F, Fernandez Aguilar S, Devroede B, Choufani G, Hassid S. Carotid artery occlusion due to fulminant rhinocerebral mucormycosis. Acta Otorhinolaryngol Belg. 2004;58:135–40.PubMed
7.
go back to reference Gelston CD, Durairaj VD, Simoes EA. Rhino-orbital mucormycosis causing cavernous sinus and internal carotid thrombosis treated with posaconazole. Arch Ophthalmol. 2007;125:848–9.CrossRefPubMed Gelston CD, Durairaj VD, Simoes EA. Rhino-orbital mucormycosis causing cavernous sinus and internal carotid thrombosis treated with posaconazole. Arch Ophthalmol. 2007;125:848–9.CrossRefPubMed
8.
go back to reference Simmons JH, Zeitler PS, Fenton LZ, Abzug MJ, Fiallo-Scharer RV, Klingensmith GJ. Rhinocerebral mucormycosis complicated by internal carotid artery thrombosis in a pediatric patient with type 1 diabetes mellitus: a case report and review of the literature. Pediatr Diabetes. 2005;6:234–8.CrossRefPubMed Simmons JH, Zeitler PS, Fenton LZ, Abzug MJ, Fiallo-Scharer RV, Klingensmith GJ. Rhinocerebral mucormycosis complicated by internal carotid artery thrombosis in a pediatric patient with type 1 diabetes mellitus: a case report and review of the literature. Pediatr Diabetes. 2005;6:234–8.CrossRefPubMed
10.
go back to reference Ramanand Y, Sidhu TS, Jaswinder K, Sharma N. An atypical presentation of cavernous sinus thrombosis. Indian J Otolaryngol Head Neck Surg. 2007;59:163–5.CrossRefPubMedPubMedCentral Ramanand Y, Sidhu TS, Jaswinder K, Sharma N. An atypical presentation of cavernous sinus thrombosis. Indian J Otolaryngol Head Neck Surg. 2007;59:163–5.CrossRefPubMedPubMedCentral
11.
go back to reference Berkhemer OA, Fransen PS, Beumer D, et al. A randomized trial of intraarterial treatment for acute ischemic stroke. N Engl J Med. 2015;372:11–20.CrossRefPubMed Berkhemer OA, Fransen PS, Beumer D, et al. A randomized trial of intraarterial treatment for acute ischemic stroke. N Engl J Med. 2015;372:11–20.CrossRefPubMed
12.
go back to reference Goyal M, Demchuk AM, Menon BK, et al. Randomized assessment of rapid endovascular treatment of ischemic stroke. N Engl J Med. 2015;372:1019–30.CrossRefPubMed Goyal M, Demchuk AM, Menon BK, et al. Randomized assessment of rapid endovascular treatment of ischemic stroke. N Engl J Med. 2015;372:1019–30.CrossRefPubMed
13.
go back to reference Saver JL, Goyal M, Bonafe A, et al. Stent-retriever thrombectomy after intravenous t-PA vs. t-PA alone in stroke. N Engl J Med. 2015;372:2285–95.CrossRefPubMed Saver JL, Goyal M, Bonafe A, et al. Stent-retriever thrombectomy after intravenous t-PA vs. t-PA alone in stroke. N Engl J Med. 2015;372:2285–95.CrossRefPubMed
14.
go back to reference Campbell BC, Mitchell PJ, Kleinig TJ, et al. Endovascular therapy for ischemic stroke with perfusion-imaging selection. N Engl J Med. 2015;372:1009–18.CrossRefPubMed Campbell BC, Mitchell PJ, Kleinig TJ, et al. Endovascular therapy for ischemic stroke with perfusion-imaging selection. N Engl J Med. 2015;372:1009–18.CrossRefPubMed
15.
go back to reference Chimowitz MI, Lynn MJ, Derdeyn CP, et al. Stenting versus aggressive medical therapy for intracranial arterial stenosis. N Engl J Med. 2011;365:993–1003.CrossRefPubMedPubMedCentral Chimowitz MI, Lynn MJ, Derdeyn CP, et al. Stenting versus aggressive medical therapy for intracranial arterial stenosis. N Engl J Med. 2011;365:993–1003.CrossRefPubMedPubMedCentral
Metadata
Title
Mucor Thrombus
Authors
E. L. Scharf
H. J. Cloft
E. Wijdicks
Publication date
01-04-2016
Publisher
Springer US
Published in
Neurocritical Care / Issue 2/2016
Print ISSN: 1541-6933
Electronic ISSN: 1556-0961
DOI
https://doi.org/10.1007/s12028-015-0186-x

Other articles of this Issue 2/2016

Neurocritical Care 2/2016 Go to the issue