Skip to main content
Top
Published in: European Radiology 5/2017

01-05-2017 | Musculoskeletal

MR signal in the sacroiliac joint space in spondyloarthritis: a new sign

Authors: Frederiek Laloo, N. Herregods, G. Varkas, J. L. Jaremko, X. Baraliakos, D. Elewaut, F. Van den Bosch, K. Verstraete, L. Jans

Published in: European Radiology | Issue 5/2017

Login to get access

Abstract

Objectives

To determine the diagnostic value of MR signal within the sacroiliac (SI) joint space in spondyloarthritis (SpA).

Methods

A retrospective analysis of MRIs of SI joints was performed in 363 patients, aged 16-45 years, clinically suspected of sacroiliitis. Intra-articular SI joint MR signals were categorized as normal, high T1 signal, fluid signal, ankylosis or vacuum phenomenon (VP). These MRI findings were correlated with the final diagnosis, according to the ASAS criteria. Sensitivity, specificity, and positive and negative likelihood ratios (LR) and predictive values were calculated.

Results

Presence of intra-articular high T1 signal, fluid signal and ankylosis had a specificity of 95.8 %, 95.3 % and 99.5 % for SpA. High T1 signal, fluid signal and ankylosis were present in 38.4 %, 19.2 % and 17.9 % of SpA patients and in 4.2 %, 4.7 % and 0.5 % of patients without SpA, resulting in LR+ of 9.0, 4.1 and 37.9, respectively. VP was present in 13.2 % of SpA patients and in 20.8 % of patients without SpA, resulting in an LR+ of 0.6.

Conclusions

Presence of high T1 signal, fluid signal and ankylosis within the SI joint on MRI have high specificity for SpA. High T1 signal is the most sensitive MRI feature within the SI joint for SpA.

Key Points

MRI of the SI joints is typically obtained for diagnosis of spondyloarthritis.
The MR signal within the SI joint itself reflects features of spondyloarthritis.
Intra-articular high T1 signal, fluid signal and ankylosis are seen in spondyloarthritis.
The vacuum phenomenon makes spondyloarthritis less likely.
Literature
2.
go back to reference Lacout A, Rousselin B, Pelage J (2008) CT and MRI of spine and sacroiliac involvement in spondylarthropathy. Am J Roentgenol 191:1016–1023CrossRef Lacout A, Rousselin B, Pelage J (2008) CT and MRI of spine and sacroiliac involvement in spondylarthropathy. Am J Roentgenol 191:1016–1023CrossRef
4.
go back to reference Jans L, Van Langenhove C, Van Praet L et al (2014) Diagnostic value of pelvic enthesitis on MRI of the sacroiliac joints in spondyloarthritis. Eur Radiol 24:866–871CrossRefPubMed Jans L, Van Langenhove C, Van Praet L et al (2014) Diagnostic value of pelvic enthesitis on MRI of the sacroiliac joints in spondyloarthritis. Eur Radiol 24:866–871CrossRefPubMed
5.
go back to reference Lambert RG, Salonen D, Rahman P et al (2007) Adalimumab significantly reduces both spinal and sacroiliac joint inflammation in patients with ankylosing spondylitis: a multicenter, randomized, double-blind, placebo-controlled study. Arthritis Rheum 56:4005–4014CrossRefPubMed Lambert RG, Salonen D, Rahman P et al (2007) Adalimumab significantly reduces both spinal and sacroiliac joint inflammation in patients with ankylosing spondylitis: a multicenter, randomized, double-blind, placebo-controlled study. Arthritis Rheum 56:4005–4014CrossRefPubMed
6.
go back to reference Smolen JS, Braun J, Dougados M et al (2014) Treating spondyloarthritis, including ankylosing spondylitis and psoriatic arthritis, to target: recommendations of an international task force. Ann Rheum Dis 73:6–16CrossRefPubMed Smolen JS, Braun J, Dougados M et al (2014) Treating spondyloarthritis, including ankylosing spondylitis and psoriatic arthritis, to target: recommendations of an international task force. Ann Rheum Dis 73:6–16CrossRefPubMed
7.
go back to reference Sieper J, Rudwaleit M, Baraliakos X et al (2009) The Assessment of Spondyloarthritis International Society (ASAS) handbook: a guide to assess spondyloarthritis. Ann Rheum Dis 68:ii1–ii44PubMed Sieper J, Rudwaleit M, Baraliakos X et al (2009) The Assessment of Spondyloarthritis International Society (ASAS) handbook: a guide to assess spondyloarthritis. Ann Rheum Dis 68:ii1–ii44PubMed
8.
go back to reference Herregods N, Jaremko JL, Baraliakos X et al (2015) Limited role of gadolinium to detect active sacroiliitis on MRI in juvenile spondyloarthritis. Skeletal Radiol 44:1637–1646CrossRefPubMed Herregods N, Jaremko JL, Baraliakos X et al (2015) Limited role of gadolinium to detect active sacroiliitis on MRI in juvenile spondyloarthritis. Skeletal Radiol 44:1637–1646CrossRefPubMed
9.
go back to reference Weber U, Pedersen SJ, Østergaard M et al (2012) Can erosions on MRI of the sacroiliac joints be reliably detected in patients with ankylosing spondylitis? - A cross-sectional study. Arthritis Res Ther 14:R124CrossRefPubMedPubMedCentral Weber U, Pedersen SJ, Østergaard M et al (2012) Can erosions on MRI of the sacroiliac joints be reliably detected in patients with ankylosing spondylitis? - A cross-sectional study. Arthritis Res Ther 14:R124CrossRefPubMedPubMedCentral
10.
go back to reference Maksymowych WP, Wichuk S, Chiowchanwisawakit P, Lambert RG, Pedersen SJ (2014) Fat metaplasia and backfill are key intermediaries in the development of sacroiliac joint ankylosis in patients with ankylosing spondylitis. Arthritis Rheumatol 66:2958–2967CrossRefPubMed Maksymowych WP, Wichuk S, Chiowchanwisawakit P, Lambert RG, Pedersen SJ (2014) Fat metaplasia and backfill are key intermediaries in the development of sacroiliac joint ankylosis in patients with ankylosing spondylitis. Arthritis Rheumatol 66:2958–2967CrossRefPubMed
11.
go back to reference Maksymowych WP, Wichuk S, Chiowchanwisawakit P, Lambert RG, Pedersen SJ (2015) Development and preliminary validation of the spondyloarthritis research consortium of Canada magnetic resonance imaging sacroiliac joint structural score. J Rheumatol 42:79–86CrossRefPubMed Maksymowych WP, Wichuk S, Chiowchanwisawakit P, Lambert RG, Pedersen SJ (2015) Development and preliminary validation of the spondyloarthritis research consortium of Canada magnetic resonance imaging sacroiliac joint structural score. J Rheumatol 42:79–86CrossRefPubMed
12.
go back to reference Gohil I, Vilensky JA, Weber EC (2014) Vacuum phenomenon: clinical relevance. Clin Anat 27:455–462CrossRefPubMed Gohil I, Vilensky JA, Weber EC (2014) Vacuum phenomenon: clinical relevance. Clin Anat 27:455–462CrossRefPubMed
13.
go back to reference Lo SS, Atceken Z, Carone M, Yousem DM (2011) Sacroiliac joint vacuum phenomenon—underreported finding. Clin Imaging 35:465–469CrossRefPubMed Lo SS, Atceken Z, Carone M, Yousem DM (2011) Sacroiliac joint vacuum phenomenon—underreported finding. Clin Imaging 35:465–469CrossRefPubMed
14.
go back to reference Spadaro A, Iagnocco A, Baccano G, Ceccarelli F, Sabatini E, Valesini G (2009) Sonographic-detected joint effusion compared with physical examination in the assessment of sacroiliac joints in spondyloarthritis. Ann Rheum Dis 68:1559–1563CrossRefPubMed Spadaro A, Iagnocco A, Baccano G, Ceccarelli F, Sabatini E, Valesini G (2009) Sonographic-detected joint effusion compared with physical examination in the assessment of sacroiliac joints in spondyloarthritis. Ann Rheum Dis 68:1559–1563CrossRefPubMed
15.
go back to reference Maksymowicz H, Kowalewski K, Lubkowska K, Zołud W, Sąsiadek M (2010) Diagnostic value of gadolinium-enhanced MR imaging of active sacroiliitis in seronegative spondyloarthropathy. Pol J Radiol 75:58–65PubMedPubMedCentral Maksymowicz H, Kowalewski K, Lubkowska K, Zołud W, Sąsiadek M (2010) Diagnostic value of gadolinium-enhanced MR imaging of active sacroiliitis in seronegative spondyloarthropathy. Pol J Radiol 75:58–65PubMedPubMedCentral
16.
go back to reference Rudwaleit M, Jurik AG, Hermann KG et al (2009) Defining active sacroiliitis on magnetic resonance imaging (MRI) for classification of axial spondyloarthritis: a consensual approach by the ASAS/OMERACT MRI group. Ann Rheum Dis 68:1520–1527CrossRefPubMed Rudwaleit M, Jurik AG, Hermann KG et al (2009) Defining active sacroiliitis on magnetic resonance imaging (MRI) for classification of axial spondyloarthritis: a consensual approach by the ASAS/OMERACT MRI group. Ann Rheum Dis 68:1520–1527CrossRefPubMed
17.
go back to reference Giraudo C, Magnaldi S, Weber M et al (2016) Optimizing the MRI protocol of the sacroiliac joints in Spondyloarthritis: which para-axial sequence should be used? Eur Radiol 26:122–129CrossRefPubMed Giraudo C, Magnaldi S, Weber M et al (2016) Optimizing the MRI protocol of the sacroiliac joints in Spondyloarthritis: which para-axial sequence should be used? Eur Radiol 26:122–129CrossRefPubMed
18.
go back to reference Arnbak B, Jensen TS, Egund N et al (2016) Prevalence of degenerative and spondyloarthritis-related magnetic resonance imaging findings in the spine and sacroiliac joints in patients with persistent low back pain. Eur Radiol 26:1191–1203CrossRefPubMed Arnbak B, Jensen TS, Egund N et al (2016) Prevalence of degenerative and spondyloarthritis-related magnetic resonance imaging findings in the spine and sacroiliac joints in patients with persistent low back pain. Eur Radiol 26:1191–1203CrossRefPubMed
19.
go back to reference Landis JR, Koch GG (1977) The measurement of observer agreement for categorical data. Biometrics 33:159–174CrossRefPubMed Landis JR, Koch GG (1977) The measurement of observer agreement for categorical data. Biometrics 33:159–174CrossRefPubMed
20.
go back to reference Jans L, Coeman L, Van Praet L et al (2014) How sensitive and specific are MRI features of sacroiliitis for diagnosis of spondyloarthritis in patients with inflammatory back pain? JBR-BTR 97:202–205PubMed Jans L, Coeman L, Van Praet L et al (2014) How sensitive and specific are MRI features of sacroiliitis for diagnosis of spondyloarthritis in patients with inflammatory back pain? JBR-BTR 97:202–205PubMed
21.
go back to reference Lories RJ, Schett G (2012) Pathophysiology of new bone formation and ankylosis in spondyloarthritis. Rheum Dis Clin North Am 38:555–567CrossRefPubMed Lories RJ, Schett G (2012) Pathophysiology of new bone formation and ankylosis in spondyloarthritis. Rheum Dis Clin North Am 38:555–567CrossRefPubMed
Metadata
Title
MR signal in the sacroiliac joint space in spondyloarthritis: a new sign
Authors
Frederiek Laloo
N. Herregods
G. Varkas
J. L. Jaremko
X. Baraliakos
D. Elewaut
F. Van den Bosch
K. Verstraete
L. Jans
Publication date
01-05-2017
Publisher
Springer Berlin Heidelberg
Published in
European Radiology / Issue 5/2017
Print ISSN: 0938-7994
Electronic ISSN: 1432-1084
DOI
https://doi.org/10.1007/s00330-016-4587-9

Other articles of this Issue 5/2017

European Radiology 5/2017 Go to the issue