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European Radiology
Published in: European Radiology 1/2017

01-01-2017 | Neuro

MR imaging of the brain in large cohort studies: feasibility report of the population- and patient-based BiDirect study

Authors: Anja Teuber, Benedikt Sundermann, Harald Kugel, Wolfram Schwindt, Walter Heindel, Jens Minnerup, Udo Dannlowski, Klaus Berger, Heike Wersching

Published in: European Radiology | Issue 1/2017

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Abstract

Objectives

To describe the implementation and protocol of cerebral magnetic resonance imaging (MRI) in the longitudinal BiDirect study and to report rates of study participation as well as management of incidental findings.

Methods

Data came from the BiDirect study that investigates the relationship between depression and arteriosclerosis and comprises 2258 participants in three cohorts: 999 patients with depression, 347 patients with manifest cardiovascular disease (CVD) and 912 population-based controls. The study program includes MRI of the brain. Reasons for non-participation were systematically collected. Incidental findings were categorized and disclosed according to clinical relevance.

Results

At baseline 2176 participants were offered MRI, of whom 1453 (67 %) completed it. Reasons for non-participation differed according to cohort, age and gender with controls showing the highest participation rate of 79 %. Patient cohorts had higher refusal rates and CVD patients a high prevalence of contraindications. In the first follow-up examination 69 % of participating subjects completed MRI.
Incidental findings were disclosed to 246 participants (17 %). The majority of incidental findings were extensive white matter hyperintensities requiring further diagnostic work-up.

Conclusions

Knowledge about subjects and sensible definition of incidental findings are crucial for large-scale imaging projects. Our data offer practical and concrete information for the design of future studies.

Key points

• Willingness to participate in MRI is generally high, also in follow-up examinations.
• Rates of refusal and prevalence of contraindications differ according to subject characteristics.
• Extensive white matter hyperintensities considerably increase the disclosure rates of incidental findings.
• MRI workflow requires continuous case-by-case handling by an interdisciplinary team.
Appendix
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Metadata
Title
MR imaging of the brain in large cohort studies: feasibility report of the population- and patient-based BiDirect study
Authors
Anja Teuber
Benedikt Sundermann
Harald Kugel
Wolfram Schwindt
Walter Heindel
Jens Minnerup
Udo Dannlowski
Klaus Berger
Heike Wersching
Publication date
01-01-2017
Publisher
Springer Berlin Heidelberg
Published in
European Radiology / Issue 1/2017
Print ISSN: 0938-7994
Electronic ISSN: 1432-1084
DOI
https://doi.org/10.1007/s00330-016-4303-9

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