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Neuroradiology

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01-04-2018 | Head-Neck-ENT Radiology

MR findings of the orbit in patients with Vogt–Koyanagi–Harada disease

Authors: Tomohiro Ando, Hiroki Kato, Kiyofumi Mochizuki, Kenji Ozawa, Satoshi Goshima, Masayuki Matsuo

Published in: Neuroradiology | Issue 4/2018

Abstract

Purpose

We aimed to evaluate the MR findings of the orbit in patients with Vogt–Koyanagi–Harada disease (VKHD).

Methods

We included 14 patients with clinically diagnosed VKHD, who underwent orbital MR imaging before treatment between May 2011 and August 2017. The mean duration from initial symptom onset to MR imaging was 16 days (range, 2–36 days). Fat-suppressed gadolinium-enhanced T1-weighted images were obtained in six patients. We retrospectively assessed the choroids and Tenon’s capsules for the presence of thickening on unenhanced images and abnormal enhancement on contrast-enhanced images.

Results

Bilateral choroidal thickening was observed in 14 patients (100%) on T1-weighted images and in 12 patients (85.7%) on T2-weighted images. Choroidal thickening showed posterior pole predominance in 11 patients (78.6%) and diffusely distributed in the remaining three patients (21.4%). Bilateral Tenon’s capsule thickening was observed in five patients (35.7%) on T1-weighted images and in 14 patients (100%) on T2-weighted images. On contrast-enhanced images, the choroids and Tenon’s capsules were abnormally enhanced in six patients (100%).

Conclusion

MR imaging sensitively detected abnormalities of the choroids and Tenon’s capsules in patients with VKHD. Bilaterality and predominant posterior pole distribution were characteristic of choroidal VKHD.

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O’Keefe GA, Rao NA (2017) Vogt-Koyanagi-Harada disease. Surv Ophthalmol 62(1):1–25. https://doi.org/10.1016/j.survophthal.2016.05.002 CrossRefPubMed

Silpa-Archa S, Silpa-Archa N, Preble JM, Foster CS (2016) Vogt-Koyanagi-Harada syndrome: perspectives for immunogenetics, multimodal imaging, and therapeutic options. Autoimmun Rev 15(8):809–819. https://doi.org/10.1016/j.autrev.2016.04.001 CrossRefPubMed

Baltmr A, Lightman S, Tomkins-Netzer O (2016) Vogt-Koyanagi-Harada syndrome—current perspectives. Clin Ophthalmol 10:2345–2361. https://doi.org/10.2147/OPTH.S94866 CrossRefPubMedPubMedCentral

Suzuki S (1999) Quantitative evaluation of “sunset glow” fundus in Vogt-Koyanagi-Harada disease. Jpn J Ophthalmol 43(4):327–333CrossRefPubMed

Johnston CA, Teitelbaum CS (1990) Magnetic resonance imaging in Vogt-Koyanagi-Harada syndrome. Arch Ophthalmol 108(6):783–784CrossRefPubMed

Ibanez HE, Grand MG, Meredith TA, Wippold FJ 2nd (1994) Magnetic resonance imaging findings in Vogt-Koyanagi-Harada syndrome. Retina 14(2):164–168CrossRefPubMed

Vaphiades MS, Read RW (2004) Magnetic resonance imaging of choroidal inflammation in Vogt-Koyanagi-Harada disease. J Neuroophthalmol 24(4):295–296CrossRefPubMed

Read RW, Holland GN, Rao NA, Tabbara KF, Ohno S, Arellanes-Garcia L, Pivetti-Pezzi P, Tessler HH, Usui M (2001) Revised diagnostic criteria for Vogt-Koyanagi-Harada disease: report of an international committee on nomenclature. Am J Ophthalmol 131(5):647–652CrossRefPubMed

Sugiura S (1978) Vogt–Koyanagi–Harada disease. Jpn J Ophthalmol 22:9–35

10.

Snyder DA, Tessler HH (1980) Vogt-Koyanagi-Harada syndrome. Am J Ophthalmol 90(1):69–75CrossRefPubMed

11.

Hashimoto T, Takizawa H, Yukimura K, Ohta K (2009) Vogt-Koyanagi-Harada disease associated with brainstem encephalitis. J Clin Neurosci 16(4):593–595. https://doi.org/10.1016/j.jocn.2008.05.029 CrossRefPubMed

12.

Han HJ, Kim HY, Park JH, Lee EJ, Kim DG, Shin DI (2010) Magnetic resonance imaging of pachymeningeal enhancement in Vogt-Koyanagi-Harada disease. Neurol Sci 31(6):785–788. https://doi.org/10.1007/s10072-010-0236-2 CrossRefPubMed

13.

Lohman BD, Gustafson CA, McKinney AM, Sarikaya B, Silbert SC (2011) MR imaging of Vogt-Koyanagi-Harada syndrome with leptomeningeal enhancement. AJNR Am J Neuroradiol 32(9):E169–E171. https://doi.org/10.3174/ajnr.A2279 CrossRefPubMed

14.

Nunes NB Jr, Bertolo G, Amaral LL, Mello SM (2013) Image findings of Vogt-Koyanagi-Harada. Arq Neuropsiquiatr 71(8):566–567. https://doi.org/10.1590/0004-282X20130087 CrossRefPubMed

15.

Hallinan JT, Pillay P, Koh LH, Goh KY, Yu WY (2016) Eye globe abnormalities on MR and CT in adults: an anatomical approach. Korean J Radiol 17(5):664–673. https://doi.org/10.3348/kjr.2016.17.5.664 CrossRefPubMedPubMedCentral

16.

Malhotra A, Minja FJ, Crum A, Burrowes D (2011) Ocular anatomy and cross-sectional imaging of the eye. Semin Ultrasound CT MR 32(1):2–13. https://doi.org/10.1053/j.sult.2010.10.009 CrossRefPubMed

17.

Kakizaki H, Takahashi Y, Nakano T, Asamoto K, Ikeda H, Ichinose A, Iwaki M, Selva D, Leibovitch I (2012) Anatomy of Tenons capsule. Clin Exp Ophthalmol 40(6):611–616. https://doi.org/10.1111/j.1442-9071.2011.02745.x CrossRefPubMed

18.

Ettl A, Salomonowitz E, Koornneef L, Zonneveld FW (1998) High-resolution MR imaging anatomy of the orbit. Correlation with comparative cryosectional anatomy. Radiol Clin North Am 36(6):1021–1045 ixCrossRefPubMed

19.

Stadler S, Dennler M, Hetzel U, Del Chicca F, Hoey S, Spiess BM, Voelter K, Pot SA (2017) Sub-Tenon’s injection in equine cadaver eyes: MRI visualization of anesthetic fluid distribution and comparison of two different volumes. Vet Ophthalmol 20(6):488–495. https://doi.org/10.1111/vop.12452 CrossRefPubMed

20.

Li CQ, Cho AA, Edward NJ, Edward DP, Fajardo RG, Mafee MF (2015) Magnetic resonance imaging of uveitis. Neuroradiology 57(8):825–832. https://doi.org/10.1007/s00234-015-1531-7 CrossRefPubMed

21.

Yang P, Ren Y, Li B, Fang W, Meng Q, Kijlstra A (2007) Clinical characteristics of Vogt-Koyanagi-Harada syndrome in Chinese patients. Ophthalmology 114(3):606–614. https://doi.org/10.1016/j.ophtha.2006.07.040 CrossRefPubMed

Title: MR findings of the orbit in patients with Vogt–Koyanagi–Harada disease
Authors: Tomohiro Ando
Hiroki Kato
Kiyofumi Mochizuki
Kenji Ozawa
Satoshi Goshima
Masayuki Matsuo
Publication date: 01-04-2018
Publisher: Springer Berlin Heidelberg
Published in: Neuroradiology / Issue 4/2018
Print ISSN: 0028-3940
Electronic ISSN: 1432-1920
DOI: https://doi.org/10.1007/s00234-018-1999-z

Keynote webinar | Spotlight on medication adherence

Springer Medicine

MR findings of the orbit in patients with Vogt–Koyanagi–Harada disease

Abstract

Purpose

Methods

Results

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusion

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Torgny Greitz, MD, PhD, FACR, Professor of Neuroradiology, Emeritus