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BMC Medicine
Published in: BMC Medicine 1/2015

Open Access 01-12-2015 | Research article

Mortality and cancer in relation to ABO blood group phenotypes in the Golestan Cohort Study

Authors: Arash Etemadi, Farin Kamangar, Farhad Islami, Hossein Poustchi, Akram Pourshams, Paul Brennan, Paolo Boffetta, Reza Malekzadeh, Sanford M Dawsey, Christian C Abnet, Ashkan Emadi

Published in: BMC Medicine | Issue 1/2015

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Abstract

Background

A few studies have shown an association between blood group alleles and vascular disease, including atherosclerosis, which is thought to be due to the higher level of von Willebrand factor in these individuals and the association of blood group locus variants with plasma lipid levels. No large population-based study has explored this association with overall and cause-specific mortality.

Methods

We aimed to study the association between ABO blood groups and overall and cause-specific mortality in the Golestan Cohort Study. In this cohort, 50,045 people 40- to 70-years old were recruited between 2004 and 2008, and followed annually to capture all incident cancers and deaths due to any cause. We used Cox regression models adjusted for age, sex, smoking, socioeconomic status, ethnicity, place of residence, education and opium use.

Results

During a total of 346,708 person-years of follow-up (mean duration 6.9 years), 3,623 cohort participants died. Non-O blood groups were associated with significantly increased total mortality (hazard ratio (HR) = 1.09; 95% confidence interval (CI): 1.01 to 1.17) and cardiovascular disease mortality (HR = 1.15; 95% CI: 1.03 to 1.27). Blood group was not significantly associated with overall cancer mortality, but people with group A, group B, and all non-O blood groups combined had increased risk of incident gastric cancer. In a subgroup of cohort participants, we also showed higher plasma total cholesterol and low-density lipoprotein (LDL) in those with blood group A.

Conclusions

Non-O blood groups have an increased mortality, particularly due to cardiovascular diseases, which may be due to the effect of blood group alleles on blood biochemistry or their effect on von Willebrand factor and factor VIII levels.
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Metadata
Title
Mortality and cancer in relation to ABO blood group phenotypes in the Golestan Cohort Study
Authors
Arash Etemadi
Farin Kamangar
Farhad Islami
Hossein Poustchi
Akram Pourshams
Paul Brennan
Paolo Boffetta
Reza Malekzadeh
Sanford M Dawsey
Christian C Abnet
Ashkan Emadi
Publication date
01-12-2015
Publisher
BioMed Central
Published in
BMC Medicine / Issue 1/2015
Electronic ISSN: 1741-7015
DOI
https://doi.org/10.1186/s12916-014-0237-8

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