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Acta Neurochirurgica

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01-10-2012 | Clinical Article

Morphometric comparison of foramen magnum in non-syndromic craniosynostosis patients with or without Chiari I malformation

Authors: J. Leikola, V. Haapamäki, A. Karppinen, V. Koljonen, J. Hukki, L. Valanne, M. Koivikko

Published in: Acta Neurochirurgica | Issue 10/2012

Abstract

Background

In order to compare the morphometry of foramen magnum (FM) in a matched-pair study, in children with non-syndromic craniosynostosis with and without Chiari I malformation (CMI), both brain magnetic resonance (MRI) and multidetector computed tomography (MDCT) images were utilized.

Methods

Brain MR images were retrieved from the Helsinki University Hospital Picture Archiving and Communications System to identify patients with CMI during 1.1.2004 to 31.3.2009. Age-, gender-, and craniosynostosis-matched controls were retrieved from the same cohort. Morphometric analysis of FM was carried out.

Results

Seven patients with non-syndromic craniosynostosis with CMI were recorded. In CMI patients, the absolute anteroposterior length was 33.4 mm as compared to 36.7 mm in controls (p = 0.023). The mean width was 28.1 and 29.9 mm (p = 0.29), and the cross-sectional area was 654.1 and 764.9 mm² (p = 0.11) in CMI and controls, respectively. In CMI patients, the relative anteroposterior length of the FM was, on average, 91 % of the control’s measurements. On average, the width was 95 % and the cross-sectional area was 88 % of the control’s results.

Conclusions

In pediatric non-syndromic craniosynostosis patients, a statistically significant reduced anteroposterior diameter of the FM is found in patients with an adjacent CMI as compared to their age-, gender-, and type-matched controls of craniosynostosis.

Aydin S, Hanimoglu H, Tanriverdi T, Yentur E, Kaynar MY (2005) Chiari type I malformations in adults: a morphometric analysis of the posterior cranial fossa. Surg Neurol 64:237–241, discussion 241PubMedCrossRef

Barkovich AJ, Wippold FJ, Sherman JL, Citrin CM (1986) Significance of cerebellar tonsillar position on MR. AJNR Am J Neuroradiol 7:795–799PubMed

Bland JM, Altman DG (1994) Matching. BMJ 309:1128PubMedCrossRef

Caldarelli M, Novegno F, Vassimi L, Romani R, Tamburrini G, Di Rocco C (2007) The role of limited posterior fossa craniectomy in the surgical treatment of Chiari malformation Type I: experience with a pediatric series. J Neurosurg 106:187–195PubMed

Cinalli G, Spennato P, Sainte-Rose C, Arnaud E, Aliberti F, Brunelle F, Cianciulli E, Renier D (2005) Chiari malformation in craniosynostosis. Childs Nerv Syst 21:889–901PubMedCrossRef

Dagtekin A, Avci E, Kara E, Uzmansel D, Dagtekin O, Koseoglu A, Talas D, Bagdatoglu C (2011) Posterior cranial fossa morphometry in symptomatic adult Chiari I malformation patients: comparative clinical and anatomical study. Clin Neurol Neurosurg 113:399–403PubMedCrossRef

Dufton JA, Habeeb SY, Heran MK, Mikulis DJ, Islam O (2011) Posterior fossa measurements in patients with and without Chiari I malformation. Can J Neurol Sci 38:452–455PubMed

Furtado SV, Thakre DJ, Venkatesh PK, Reddy K, Hegde AS (2010) Morphometric analysis of foramen magnum dimensions and intracranial volume in pediatric Chiari I malformation. Acta Neurochir (Wien) 152:221–227, discussion 227CrossRef

Gehweiler JA Jr, Daffner RH, Roberts L Jr (1983) Malformations of the atlas vertebra simulating the Jefferson fracture. AJR Am J Roentgenol 140:1083–1086PubMed

10.

Gladstone JP, Dodick DW (2004) Revised 2004 International Classification of Headache Disorders: new headache types. Can J Neurol Sci 31:304–314PubMed

11.

Hecht JT, Nelson FW, Butler IJ, Horton WA, Scott CI Jr, Wassman ER, Mehringer CM, Rimoin DL, Pauli RM (1985) Computerized tomography of the foramen magnum: achondroplastic values compared to normal standards. Am J Med Genet 20:355–360PubMedCrossRef

12.

Leikola J, Koljonen V, Valanne L, Hukki J (2009) The incidence of Chiari malformation in nonsyndromic, single suture craniosynostosis. Childs Nerv Syst

13.

Mikulis DJ, Diaz O, Egglin TK, Sanchez R (1992) Variance of the position of the cerebellar tonsils with age: preliminary report. Radiology 183:725–728PubMed

14.

Noudel R, Jovenin N, Eap C, Scherpereel B, Pierot L, Rousseaux P (2009) Incidence of basioccipital hypoplasia in Chiari malformation type I: comparative morphometric study of the posterior cranial fossa. Clinical article. J Neurosurg 111:1046–1052PubMedCrossRef

15.

Novegno F, Caldarelli M, Massa A, Chieffo D, Massimi L, Pettorini B, Tamburrini G, Di Rocco C (2008) The natural history of the Chiari Type I anomaly. J Neurosurg Pediatr 2:179–187PubMedCrossRef

16.

Sgouros S, Kountouri M, Natarajan K (2006) Posterior fossa volume in children with Chiari malformation Type I. J Neurosurg 105:101–106PubMed

17.

Sgouros S, Kountouri M, Natarajan K (2007) Skull base growth in children with Chiari malformation Type I. J Neurosurg 107:188–192PubMed

18.

Tubbs RS, Bailey M, Barrow WC, Loukas M, Shoja MM, Oakes WJ (2009) Morphometric analysis of the craniocervical juncture in children with Chiari I malformation and concomitant syringobulbia. Childs Nerv Syst 25:689–692PubMedCrossRef

19.

Tubbs RS, Lancaster JR, Mortazavi MM, Shoja MM, Chern JJ, Loukas M, Cohen-Gadol AA (2011) Morphometry of the outlet of the foramen magnum in crania with atlantooccipital fusion. J Neurosurg Spine 15:55–59PubMedCrossRef

20.

Van den Broek MJ, Arbues AS, Chalard F, Pinto Da Costa NM, Trang H, Dorfmuller G, Evrard PP, Husson I, Servais LJ (2009) Chiari type I malformation causing central apnoeas in a 4-month-old boy. Eur J Paediatr Neurol 13:463–465PubMedCrossRef

Title: Morphometric comparison of foramen magnum in non-syndromic craniosynostosis patients with or without Chiari I malformation
Authors: J. Leikola
V. Haapamäki
A. Karppinen
V. Koljonen
J. Hukki
L. Valanne
M. Koivikko
Publication date: 01-10-2012
Publisher: Springer Vienna
Published in: Acta Neurochirurgica / Issue 10/2012
Print ISSN: 0001-6268
Electronic ISSN: 0942-0940
DOI: https://doi.org/10.1007/s00701-012-1451-9

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Morphometric comparison of foramen magnum in non-syndromic craniosynostosis patients with or without Chiari I malformation

Abstract

Background

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Methods

Results

Conclusions

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