More than just skin deep!

Excerpt

Dear EditorMuir–Torre syndrome (MTS), classified as a genodermatosis, is a rare variant of hereditary non-polyposis colorectal cancer (HNPCC). It presents as a sebaceous neoplasm associated with a visceral malignancy. Families with MTS suffer from multiple malignancies owing to a genetic defect in the mismatch repair genes. However, the genetic basis of the syndrome has not been fully understood. The excellent prognosis associated with MTS warrants early recognition. Previous reports of MTS have been limited to the white population. The low prevalence of MTS in the Asian and African populations as compared to the white population is probably due to cases going unrecognized rather than a racial or regional susceptibility. We report a family of MTS from India identified and treated by us. To our knowledge, this is the first such report from India. …