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Journal of Orthopaedic Science

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01-09-2013 | Original Article

More radial shortening after low-energy Colles’ fractures is associated with type 2 diabetes mellitus among postmenopausal women, irrespective of bone mineral density

Authors: Akinori Sakai, Kunitaka Menuki, Yukichi Zenke, Yoshiaki Yamanaka, Kayoko Furukawa, Yoshifumi Fuse

Published in: Journal of Orthopaedic Science | Issue 5/2013

Abstract

Background

Recent meta-analysis data reveal that patients with type 2 diabetes mellitus (DM) have a higher risk of fracture, despite higher bone mineral density (BMD), than patients without type 2 DM. The purpose of this study was to compare BMD and distal radial shortening after low-energy Colles’ fractures among Japanese postmenopausal women aged ≥50 years with type 2 DM with those in women without it (non-DM).

Methods

One-hundred and ten postmenopausal women aged ≥50 years with distal radius fractures resulting from a fall were enrolled in this study. Twelve patients had DM. BMD, type I collagen cross-linked N-telopeptide (NTX), undercarboxylated osteocalcin (ucOC), estimated glomerular filtration rate (eGFR), grip strength of the unfractured hand, unipedal standing time, and the degree of radial shortening were measured.

Results

There were no significant differences in age and body height between the two groups. The DM group had significantly greater body weight and body mass index than the non-DM group. BMDs of the lumbar spine and proximal hip were significantly higher in the DM group than in the non-DM group. NTX, ucOC, grip strength, and the percentage of women with unipedal standing time <15 s did not differ between the two groups. Stepwise regression analysis identified DM and shorter unipedal standing time as significant factors associated with more radial shortening, and identified more radial shortening and lower eGFR as significant factors associated with DM.

Conclusions

More radial shortening after low-energy Colles’ fractures was significantly associated with type 2 DM among postmenopausal women aged ≥50 years, irrespective of BMD.

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Title: More radial shortening after low-energy Colles’ fractures is associated with type 2 diabetes mellitus among postmenopausal women, irrespective of bone mineral density
Authors: Akinori Sakai
Kunitaka Menuki
Yukichi Zenke
Yoshiaki Yamanaka
Kayoko Furukawa
Yoshifumi Fuse
Publication date: 01-09-2013
Publisher: Springer Japan
Published in: Journal of Orthopaedic Science / Issue 5/2013
Print ISSN: 0949-2658
Electronic ISSN: 1436-2023
DOI: https://doi.org/10.1007/s00776-013-0419-9

At a glance: The STEP trials

Springer Medicine

More radial shortening after low-energy Colles’ fractures is associated with type 2 diabetes mellitus among postmenopausal women, irrespective of bone mineral density

Abstract

Background

Methods

Results

Conclusions

At a glance: The STEP trials

Springer Medicine

Abstract

Background

Methods

Results

Conclusions

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