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Breast Cancer Research
Published in: Breast Cancer Research 2/2011

01-04-2011 | Viewpoint

More on FOX News: FOXA1 on the horizon of estrogen receptor function and endocrine response

Authors: Xiaoyong Fu, Catherine Huang, Rachel Schiff

Published in: Breast Cancer Research | Issue 2/2011

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Abstract

Estrogen receptor α (ER) is a major driver of breast cancer and the target of endocrine therapy. Full disclosure of the cofactors regulating ER interactions with chromatin and its transcriptional regulatory activity is still elusive. Novel genome-wide profiling tools have mapped ER binding events in breast cancer cells and delineated cofactors important in ER activity. Among these, the Forkhead protein FOXA1 is emerging as a key factor dictating global chromatin structure and the transcriptional function of ER in breast and non-breast cancer cells. The significance of FOXA1 in the chromatin interactions and transcriptional regulation of both estrogen- and tamoxifen-bound ER, and in supporting tamoxifen-resistant cell growth, may impact current endocrine therapies.
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Metadata
Title
More on FOX News: FOXA1 on the horizon of estrogen receptor function and endocrine response
Authors
Xiaoyong Fu
Catherine Huang
Rachel Schiff
Publication date
01-04-2011
Publisher
BioMed Central
Published in
Breast Cancer Research / Issue 2/2011
Electronic ISSN: 1465-542X
DOI
https://doi.org/10.1186/bcr2849

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