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Published in: Osteoporosis International 8/2013

01-08-2013 | Original Article

Morbidity following lower extremity fractures in men with spinal cord injury

Authors: L. D. Carbone, A. S. Chin, S. P. Burns, J. N. Svircev, H. Hoenig, M. Heggeness, F. Weaver

Published in: Osteoporosis International | Issue 8/2013

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Abstract

Summary

The Veterans Affairs Spinal Cord Dysfunction Registry from 2002 to 2007 was reviewed to determine whether men with spinal cord injury (SCI) and lower extremity fractures had an increased risk of complications compared to those without fractures. We determined that fractures are associated with significant consequences, particularly during the first month postfracture.

Introduction

Despite increasing longevity, patients with SCI have a substantial number of illnesses and comorbid conditions. Lower extremity fractures are frequent events in these patients. However, whether these fractures are associated with any increased risk of complications in SCI is not certain. The purpose of this report was to determine the impact of lower extremity fractures on morbidities in men with SCI.

Methods

A population-based, nested, case–control (1,027 cases and 1,027 propensity-matched controls) of men enrolled in the Veterans Affairs Spinal Cord Dysfunction Registry from fiscal years 2002 to 2007 was reviewed to determine whether lower extremity fractures were associated with an increased risk for complications.

Results

In propensity score models matched for demographic (age, race) and SCI-related injury factors (level/completeness of SCI), Veterans Affairs-service connection status, and comorbidities, at 1 month following the fracture, there was an increased risk for respiratory infections, pressure ulcers, urinary tract infections, thromboembolic events, depression, and delirium (p ≤ 0.03 for all). Over 12 months, the only complication more common in fracture cases was pressure ulcers (p < 0.01), with an absolute difference of less than 2 % when compared to controls. There was no significant increased risk of cardiac arrhythmias at any time examined following fracture (≥0.12).

Conclusions

Lower extremity fractures are associated with significant consequences in men with SCI during the first month postfracture, but they do not persist for a long term, except for pressure ulcers. Targeted interventions to prevent complications should be considered following lower extremity fractures in SCI, particularly in the first month following fracture.
Literature
2.
go back to reference Ragnarsson KT, Sell GH (1981) Lower extremity fractures after spinal cord injury: a retrospective study. Arch Phys Med Rehabil 62(9):418–423PubMed Ragnarsson KT, Sell GH (1981) Lower extremity fractures after spinal cord injury: a retrospective study. Arch Phys Med Rehabil 62(9):418–423PubMed
3.
go back to reference Freehafer AA, Hazel CM, Becker CL (1981) Lower extremity fractures in patients with spinal cord injury. Paraplegia 19(6):367–372PubMedCrossRef Freehafer AA, Hazel CM, Becker CL (1981) Lower extremity fractures in patients with spinal cord injury. Paraplegia 19(6):367–372PubMedCrossRef
4.
go back to reference Ingram RR, Suman RK, Freeman PA (1989) Lower limb fractures in the chronic spinal cord injured patient. Paraplegia 27(2):133–139PubMedCrossRef Ingram RR, Suman RK, Freeman PA (1989) Lower limb fractures in the chronic spinal cord injured patient. Paraplegia 27(2):133–139PubMedCrossRef
5.
go back to reference Zehnder Y et al (2004) Long-term changes in bone metabolism, bone mineral density, quantitative ultrasound parameters, and fracture incidence after spinal cord injury: a cross-sectional observational study in 100 paraplegic men. Osteoporos Int 15(3):180–189PubMedCrossRef Zehnder Y et al (2004) Long-term changes in bone metabolism, bone mineral density, quantitative ultrasound parameters, and fracture incidence after spinal cord injury: a cross-sectional observational study in 100 paraplegic men. Osteoporos Int 15(3):180–189PubMedCrossRef
6.
go back to reference Frisbie JH (1997) Fractures after myelopathy: the risk quantified. J Spinal Cord Med 20(1):66–69PubMed Frisbie JH (1997) Fractures after myelopathy: the risk quantified. J Spinal Cord Med 20(1):66–69PubMed
7.
go back to reference Nottage WM (1981) A review of long-bone fractures in patients with spinal cord injuries. Clin Orthop Relat Res 155:65–70PubMed Nottage WM (1981) A review of long-bone fractures in patients with spinal cord injuries. Clin Orthop Relat Res 155:65–70PubMed
8.
go back to reference Lazo MG et al (2001) Osteoporosis and risk of fracture in men with spinal cord injury. Spinal Cord 39(4):208–214PubMedCrossRef Lazo MG et al (2001) Osteoporosis and risk of fracture in men with spinal cord injury. Spinal Cord 39(4):208–214PubMedCrossRef
9.
go back to reference Burns AS, O'Connell C (2012) The challenge of spinal cord injury care in the developing world. J Spinal Cord Med 35(1):3–8PubMedCrossRef Burns AS, O'Connell C (2012) The challenge of spinal cord injury care in the developing world. J Spinal Cord Med 35(1):3–8PubMedCrossRef
10.
go back to reference Smith BM et al (2007) Acute respiratory tract infection visits of veterans with spinal cord injuries and disorders: rates, trends, and risk factors. J Spinal Cord Med 30(4):355–361PubMed Smith BM et al (2007) Acute respiratory tract infection visits of veterans with spinal cord injuries and disorders: rates, trends, and risk factors. J Spinal Cord Med 30(4):355–361PubMed
11.
go back to reference Weaver FM et al (2006) Outcomes of outpatient visits for acute respiratory illness in veterans with spinal cord injuries and disorders. Am J Phys Med Rehabil 85(9):718–726PubMedCrossRef Weaver FM et al (2006) Outcomes of outpatient visits for acute respiratory illness in veterans with spinal cord injuries and disorders. Am J Phys Med Rehabil 85(9):718–726PubMedCrossRef
12.
go back to reference Byrne DW, Salzberg CA (1996) Major risk factors for pressure ulcers in the spinal cord disabled: a literature review. Spinal Cord 34(5):255–263PubMedCrossRef Byrne DW, Salzberg CA (1996) Major risk factors for pressure ulcers in the spinal cord disabled: a literature review. Spinal Cord 34(5):255–263PubMedCrossRef
13.
go back to reference Garcia Leoni ME, Esclarin De Ruz A (2003) Management of urinary tract infection in patients with spinal cord injuries. Clin Microbiol Infect 9(8):780–785PubMedCrossRef Garcia Leoni ME, Esclarin De Ruz A (2003) Management of urinary tract infection in patients with spinal cord injuries. Clin Microbiol Infect 9(8):780–785PubMedCrossRef
14.
go back to reference Kadyan V et al (2003) Surveillance with duplex ultrasound in traumatic spinal cord injury on initial admission to rehabilitation. J Spinal Cord Med 26(3):231–235PubMed Kadyan V et al (2003) Surveillance with duplex ultrasound in traumatic spinal cord injury on initial admission to rehabilitation. J Spinal Cord Med 26(3):231–235PubMed
15.
go back to reference Elliott TR, Frank RG (1996) Depression following spinal cord injury. Arch Phys Med Rehabil 77(8):816–823PubMedCrossRef Elliott TR, Frank RG (1996) Depression following spinal cord injury. Arch Phys Med Rehabil 77(8):816–823PubMedCrossRef
16.
go back to reference Frank RG et al (1987) Differences in coping styles among persons with spinal cord injury: a cluster-analytic approach. J Consult Clin Psychol 55(5):727–731PubMedCrossRef Frank RG et al (1987) Differences in coping styles among persons with spinal cord injury: a cluster-analytic approach. J Consult Clin Psychol 55(5):727–731PubMedCrossRef
17.
go back to reference Ravensbergen HJ et al (2012) Electrocardiogram-based predictors for arrhythmia after spinal cord injury. Clin Auton Res 22(6):265–273PubMedCrossRef Ravensbergen HJ et al (2012) Electrocardiogram-based predictors for arrhythmia after spinal cord injury. Clin Auton Res 22(6):265–273PubMedCrossRef
18.
go back to reference Echigoya Y, Kato H (2008) Postoperative complications after femoral neck fracture in advanced elderly patients. Masui 57(2):163–166PubMed Echigoya Y, Kato H (2008) Postoperative complications after femoral neck fracture in advanced elderly patients. Masui 57(2):163–166PubMed
19.
go back to reference Johnson EE, Kay RM, Dorey FJ (1994) Heterotopic ossification prophylaxis following operative treatment of acetabular fracture. Clin Orthop Relat Res 305:88–95PubMed Johnson EE, Kay RM, Dorey FJ (1994) Heterotopic ossification prophylaxis following operative treatment of acetabular fracture. Clin Orthop Relat Res 305:88–95PubMed
20.
go back to reference Merchant RA et al (2005) The relationship between postoperative complications and outcomes after hip fracture surgery. Ann Acad Med Singapore 34(2):163–168PubMed Merchant RA et al (2005) The relationship between postoperative complications and outcomes after hip fracture surgery. Ann Acad Med Singapore 34(2):163–168PubMed
21.
go back to reference Smith BM et al (2010) Using VA data for research in persons with spinal cord injuries and disorders: lessons from SCI QUERI. J Rehabil Res Dev 47(8):679–688PubMedCrossRef Smith BM et al (2010) Using VA data for research in persons with spinal cord injuries and disorders: lessons from SCI QUERI. J Rehabil Res Dev 47(8):679–688PubMedCrossRef
22.
go back to reference Logan WC Jr et al (2008) Incidence of fractures in a cohort of veterans with chronic multiple sclerosis or traumatic spinal cord injury. Arch Phys Med Rehabil 89(2):237–243PubMedCrossRef Logan WC Jr et al (2008) Incidence of fractures in a cohort of veterans with chronic multiple sclerosis or traumatic spinal cord injury. Arch Phys Med Rehabil 89(2):237–243PubMedCrossRef
23.
go back to reference Weaver FM et al (2008) Providing all-inclusive care for frail elderly veterans: evaluation of three models of care. J Am Geriatr Soc 56(2):345–353PubMedCrossRef Weaver FM et al (2008) Providing all-inclusive care for frail elderly veterans: evaluation of three models of care. J Am Geriatr Soc 56(2):345–353PubMedCrossRef
24.
go back to reference Charlson ME et al (1987) A new method of classifying prognostic comorbidity in longitudinal studies: development and validation. J Chronic Dis 40(5):373–383PubMedCrossRef Charlson ME et al (1987) A new method of classifying prognostic comorbidity in longitudinal studies: development and validation. J Chronic Dis 40(5):373–383PubMedCrossRef
25.
go back to reference Mezuk B, Eaton WW, Golden SH (2008) Depression and osteoporosis: epidemiology and potential mediating pathways. Osteoporos Int 19(1):1–12PubMedCrossRef Mezuk B, Eaton WW, Golden SH (2008) Depression and osteoporosis: epidemiology and potential mediating pathways. Osteoporos Int 19(1):1–12PubMedCrossRef
26.
go back to reference van den Berg M et al (2011) Depression after low-energy fracture in older women predicts future falls: a prospective observational study. BMC Geriatr 11:73PubMedCrossRef van den Berg M et al (2011) Depression after low-energy fracture in older women predicts future falls: a prospective observational study. BMC Geriatr 11:73PubMedCrossRef
27.
go back to reference Hanlon JT et al (2011) Potential underuse, overuse, and inappropriate use of antidepressants in older veteran nursing home residents. J Am Geriatr Soc 59(8):1412–1420PubMedCrossRef Hanlon JT et al (2011) Potential underuse, overuse, and inappropriate use of antidepressants in older veteran nursing home residents. J Am Geriatr Soc 59(8):1412–1420PubMedCrossRef
28.
go back to reference Quan H et al (2005) Coding algorithms for defining comorbidities in ICD-9-CM and ICD-10 administrative data. Med Care 43(11):1130–1139PubMedCrossRef Quan H et al (2005) Coding algorithms for defining comorbidities in ICD-9-CM and ICD-10 administrative data. Med Care 43(11):1130–1139PubMedCrossRef
29.
go back to reference Morse LR et al (2009) Osteoporotic fractures and hospitalization risk in chronic spinal cord injury. Osteoporos Int 20(3):385–392PubMedCrossRef Morse LR et al (2009) Osteoporotic fractures and hospitalization risk in chronic spinal cord injury. Osteoporos Int 20(3):385–392PubMedCrossRef
30.
go back to reference Monte-Secades R et al (2011) Risk factors for the development of medical complications in patients with hip fracture. Rev Calid Asist 26(2):76–82PubMedCrossRef Monte-Secades R et al (2011) Risk factors for the development of medical complications in patients with hip fracture. Rev Calid Asist 26(2):76–82PubMedCrossRef
31.
go back to reference Beaupre LA et al (2006) Reduced morbidity for elderly patients with a hip fracture after implementation of a perioperative evidence-based clinical pathway. Qual Saf Health Care 15(5):375–379PubMedCrossRef Beaupre LA et al (2006) Reduced morbidity for elderly patients with a hip fracture after implementation of a perioperative evidence-based clinical pathway. Qual Saf Health Care 15(5):375–379PubMedCrossRef
32.
go back to reference Anand S, Buch K (2007) Post-discharge symptomatic thromboembolic events in hip fracture patients. Ann R Coll Surg Engl 89(5):517–520PubMedCrossRef Anand S, Buch K (2007) Post-discharge symptomatic thromboembolic events in hip fracture patients. Ann R Coll Surg Engl 89(5):517–520PubMedCrossRef
33.
go back to reference Mossey JM, Knott K, Craik R (1990) The effects of persistent depressive symptoms on hip fracture recovery. J Gerontol 45(5):M163–M168PubMedCrossRef Mossey JM, Knott K, Craik R (1990) The effects of persistent depressive symptoms on hip fracture recovery. J Gerontol 45(5):M163–M168PubMedCrossRef
34.
go back to reference Henzel MK et al (2011) Pressure ulcer management and research priorities for patients with spinal cord injury: consensus opinion from SCI QUERI Expert Panel on Pressure Ulcer Research Implementation. J Rehabil Res Dev 48(3):xi–xxxiiPubMedCrossRef Henzel MK et al (2011) Pressure ulcer management and research priorities for patients with spinal cord injury: consensus opinion from SCI QUERI Expert Panel on Pressure Ulcer Research Implementation. J Rehabil Res Dev 48(3):xi–xxxiiPubMedCrossRef
35.
go back to reference Evans CT et al (2010) Antibiotic prescribing for acute respiratory infection and subsequent outpatient and hospital utilization in veterans with spinal cord injury and disorder. PM & R J Inj Funct Rehabil 2(2):101–109CrossRef Evans CT et al (2010) Antibiotic prescribing for acute respiratory infection and subsequent outpatient and hospital utilization in veterans with spinal cord injury and disorder. PM & R J Inj Funct Rehabil 2(2):101–109CrossRef
36.
go back to reference Teasell RW et al (2009) Venous thromboembolism after spinal cord injury. Arch Phys Med Rehabil 90(2):232–245PubMedCrossRef Teasell RW et al (2009) Venous thromboembolism after spinal cord injury. Arch Phys Med Rehabil 90(2):232–245PubMedCrossRef
37.
go back to reference Peng CT et al (1998) Prolonged severe withdrawal symptoms after acute-on-chronic baclofen overdose. J Toxicol Clin Toxicol 36(4):359–363PubMedCrossRef Peng CT et al (1998) Prolonged severe withdrawal symptoms after acute-on-chronic baclofen overdose. J Toxicol Clin Toxicol 36(4):359–363PubMedCrossRef
38.
go back to reference Catic AG (2011) Identification and management of in-hospital drug-induced delirium in older patients. Drugs Aging 28(9):737–748PubMedCrossRef Catic AG (2011) Identification and management of in-hospital drug-induced delirium in older patients. Drugs Aging 28(9):737–748PubMedCrossRef
39.
go back to reference Montgomerie JZ (1997) Infections in patients with spinal cord injuries. Clin Infect Dis 25(6):1285–1290, quiz 1291-2PubMedCrossRef Montgomerie JZ (1997) Infections in patients with spinal cord injuries. Clin Infect Dis 25(6):1285–1290, quiz 1291-2PubMedCrossRef
40.
go back to reference Evans CT et al (2008) Epidemiology of hospital-acquired infections in veterans with spinal cord injury and disorder. Infect Control Hosp Epidemiol 29(3):234–242PubMedCrossRef Evans CT et al (2008) Epidemiology of hospital-acquired infections in veterans with spinal cord injury and disorder. Infect Control Hosp Epidemiol 29(3):234–242PubMedCrossRef
Metadata
Title
Morbidity following lower extremity fractures in men with spinal cord injury
Authors
L. D. Carbone
A. S. Chin
S. P. Burns
J. N. Svircev
H. Hoenig
M. Heggeness
F. Weaver
Publication date
01-08-2013
Publisher
Springer London
Published in
Osteoporosis International / Issue 8/2013
Print ISSN: 0937-941X
Electronic ISSN: 1433-2965
DOI
https://doi.org/10.1007/s00198-013-2295-8

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