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BMC Primary Care
Published in: BMC Primary Care 1/2020

Open Access 01-12-2020 | Mood Disorders | Research article

Collaborative care for depression and anxiety disorders: results and lessons learned from the Danish cluster-randomized Collabri trials

Authors: Nadja Kehler Curth, Ursula Ødum Brinck-Claussen, Carsten Hjorthøj, Annette Sofie Davidsen, John Hagel Mikkelsen, Marianne Engelbrecht Lau, Merete Lundsteen, Claudio Csillag, Kaj Sparle Christensen, Marie Jakobsen, Anders Bo Bojesen, Merete Nordentoft, Lene Falgaard Eplov

Published in: BMC Primary Care | Issue 1/2020

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Abstract

Background

Meta-analyses suggest that collaborative care (CC) improves symptoms of depression and anxiety. In CC, a care manager collaborates with a general practitioner (GP) to provide evidence-based care. Most CC research is from the US, focusing on depression. As research results may not transfer to other settings, we developed and tested a Danish CC-model (the Collabri-model) for depression, panic disorder, generalized anxiety disorder, and social anxiety disorder in general practice.

Methods

Four cluster-randomized superiority trials evaluated the effects of CC. The overall aim was to explore if CC significantly improved depression and anxiety symptoms compared to treatment-as-usual at 6-months’ follow-up. The Collabri-model was founded on a multi-professional collaboration between a team of mental-health specialists (psychiatrists and care managers) and GPs. In collaboration with GPs, care managers provided treatment according to a structured plan, including regular reassessments and follow-up. Treatment modalities (cognitive behavioral therapy, psychoeducation, and medication) were offered based on stepped care algorithms. Face-to-face meetings between GPs and care managers took place regularly, and a psychiatrist provided supervision. The control group received treatment-as-usual. Primary outcomes were symptoms of depression (BDI-II) and anxiety (BAI) at 6-months’ follow-up. The incremental cost-effectiveness ratio (ICER) was estimated based on 6-months’ follow-up.

Results

Despite various attempts to improve inclusion rates, the necessary number of participants was not recruited. Seven hundred thirty-one participants were included: 325 in the depression trial and 406 in the anxiety trials. The Collabri-model was implemented, demonstrating good fidelity to core model elements. In favor of CC, we found a statistically significant difference between depression scores at 6-months’ follow-up in the depression trial. The difference was not significant at 15-months’ follow-up. The anxiety trials were pooled for data analysis due to inadequate sample sizes. At 6- and 15-months’ follow-up, there was a difference in anxiety symptoms favoring CC. These differences were not statistically significant. The ICER was 58,280 Euro per QALY.

Conclusions

At 6 months, a significant difference between groups was found in the depression trial, but not in the pooled anxiety trial. However, these results should be cautiously interpreted as there is a risk of selection bias and lacking statistical power.

Trial registration

ClinicalTrials.gov, ID: NCT02678624 and NCT02678845. Retrospectively registered on 7 February 2016.
Appendix
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Metadata
Title
Collaborative care for depression and anxiety disorders: results and lessons learned from the Danish cluster-randomized Collabri trials
Authors
Nadja Kehler Curth
Ursula Ødum Brinck-Claussen
Carsten Hjorthøj
Annette Sofie Davidsen
John Hagel Mikkelsen
Marianne Engelbrecht Lau
Merete Lundsteen
Claudio Csillag
Kaj Sparle Christensen
Marie Jakobsen
Anders Bo Bojesen
Merete Nordentoft
Lene Falgaard Eplov
Publication date
01-12-2020
Publisher
BioMed Central
Published in
BMC Primary Care / Issue 1/2020
Electronic ISSN: 2731-4553
DOI
https://doi.org/10.1186/s12875-020-01299-3

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