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European Archives of Psychiatry and Clinical Neuroscience

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Open Access 28-08-2023 | Mood Disorders | Original Paper

Motor performance and functional connectivity between the posterior cingulate cortex and supplementary motor cortex in bipolar and unipolar depression

Authors: Lara E. Marten, Aditya Singh, Anna M. Muellen, Sören M. Noack, Vladislav Kozyrev, Renate Schweizer, Roberto Goya-Maldonado

Published in: European Archives of Psychiatry and Clinical Neuroscience | Issue 3/2024

Abstract

Although implicated in unsuccessful treatment, psychomotor deficits and their neurobiological underpinnings in bipolar (BD) and unipolar (UD) depression remain poorly investigated. Here, we hypothesized that motor performance deficits in depressed patients would relate to basal functional coupling of the hand primary motor cortex (M1) and the posterior cingulate cortex (PCC) with the supplementary motor area (SMA). We performed a longitudinal, naturalistic study in BD, UD and matched healthy controls comprising of two resting-state functional MRI measurements five weeks apart and accompanying assessments of motor performance using a finger tapping task (FTT). A subject-specific seed-based analysis describing functional connectivity between PCC-SMA as well as M1-SMA was conducted. The basal relationships with motor performance were investigated using linear regression models and all measures were compared across groups. Performance in FTT was impaired in BD in comparison to HC in both sessions. Behavioral performance across groups correlated significantly with resting state functional coupling of PCC–SMA, but not of M1-SMA regions. This relationship was partially reflected in a reduced PCC–SMA connectivity in BD vs HC in the second session. Exploratory evaluation of large-scale networks coupling (SMN–DMN) exhibited no correlation to motor performance. Our results shed new light on the association between the degree of disruption in the SMA–PCC anticorrelation and the level of motor impairment in BD.

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Title: Motor performance and functional connectivity between the posterior cingulate cortex and supplementary motor cortex in bipolar and unipolar depression
Authors: Lara E. Marten
Aditya Singh
Anna M. Muellen
Sören M. Noack
Vladislav Kozyrev
Renate Schweizer
Roberto Goya-Maldonado
Publication date: 28-08-2023
Publisher: Springer Berlin Heidelberg
Keywords: Mood Disorders
Affective Disorder
Published in: European Archives of Psychiatry and Clinical Neuroscience / Issue 3/2024
Print ISSN: 0940-1334
Electronic ISSN: 1433-8491
DOI: https://doi.org/10.1007/s00406-023-01671-1

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Motor performance and functional connectivity between the posterior cingulate cortex and supplementary motor cortex in bipolar and unipolar depression

Abstract

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

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