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01-11-2018 | Neurology and Preclinical Neurological Studies - Review Article

Monoamine oxidase-A, serotonin and norepinephrine: synergistic players in cardiac physiology and pathology

Authors: Jeanne Mialet-Perez, Yohan Santin, Angelo Parini

Published in: Journal of Neural Transmission | Issue 11/2018

Abstract

The mitochondrial enzyme monoamine oxidase A (MAO-A) is widely distributed in neuronal, myocyte and non-myocyte cardiac compartments. After the demonstrations that both cardiac neuronal and extraneuronal MAO-A contribute to the degradation of norepinephrine and serotonin, several studies attempted to determine the impact of MAO-A activity in the control of local concentration of the two biogenic amines and in their receptor-mediated effects. From the 2000s, an additional mechanism of action of MAO-A has been proposed. Such mechanism involves hydrogen peroxide (H₂O₂) production during substrate degradation. This finding stimulated a growing interest on the role of MAO-A-dependent oxidative stress in cardiac pathophysiology. Altogether, the results obtained by different groups showed that MAO-A played a key role in the regulation of physiological cardiac function and in the development of acute and chronic heart diseases through two mechanisms: the regulation of substrate concentrations and the intracellular production of reactive oxygen species. In this review, we will give an overview of the major results on the role of MAO-A in the field of cardiac diseases.

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Title: Monoamine oxidase-A, serotonin and norepinephrine: synergistic players in cardiac physiology and pathology
Authors: Jeanne Mialet-Perez
Yohan Santin
Angelo Parini
Publication date: 01-11-2018
Publisher: Springer Vienna
Published in: Journal of Neural Transmission / Issue 11/2018
Print ISSN: 0300-9564
Electronic ISSN: 1435-1463
DOI: https://doi.org/10.1007/s00702-018-1908-y

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Monoamine oxidase-A, serotonin and norepinephrine: synergistic players in cardiac physiology and pathology

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