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Journal of Clinical Monitoring and Computing

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01-08-2014 | Original Research

Monitoring of intense neuromuscular blockade in a pig model

Authors: Matias V. Madsen, Anders M. Donatsky, Bente R. Jensen, Jacob Rosenberg, Karsten P. Hammelev, Mona R. Gätke

Published in: Journal of Clinical Monitoring and Computing | Issue 4/2014

Abstract

Intense neuromuscular blockade (NMB) measured by post tetanic count (PTC) was monitored, reversed and verified in this pig model. In a cross-over assessor blinded design six pigs were randomized to either no NMB followed by intense NMB, or intense NMB followed by no NMB. Neuromuscular measurements were performed with acceleromyography [train-of-four (TOF) Watch SX]. In all pigs, the response to TOF nerve stimulation was stable and intense NMB (PTC 0–1) was established with rocuronium 3 mg/kg. For reversal, the pigs received sugammadex 20–35 mg/kg and returned to TOF-ratio above 0.90 within 2.15 min after injection. We established a pig model for monitoring intense NMB with surface stimulation electrodes and acceleromyography. We verified total relaxation of the diaphragm and the abdominal muscles at the PTC 0–1 by suction test and with surface electromyography. This pig model is suitable for studies with experimental abdominal surgery with monitoring of intense NMB, and where relaxation of the diaphragm and the abdominal muscles are required.

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Title: Monitoring of intense neuromuscular blockade in a pig model
Authors: Matias V. Madsen
Anders M. Donatsky
Bente R. Jensen
Jacob Rosenberg
Karsten P. Hammelev
Mona R. Gätke
Publication date: 01-08-2014
Publisher: Springer Netherlands
Published in: Journal of Clinical Monitoring and Computing / Issue 4/2014
Print ISSN: 1387-1307
Electronic ISSN: 1573-2614
DOI: https://doi.org/10.1007/s10877-013-9539-1

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Monitoring of intense neuromuscular blockade in a pig model

Abstract

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

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