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Open Access 01-06-2006 | Research

Molecular signatures induced by interleukin-2 on peripheral blood mononuclear cells and T cell subsets

Authors: Ping Jin, Ena Wang, Maurizio Provenzano, Sara Deola, Silvia Selleri, Jiaqiang Ren, Sonia Voiculescu, David Stroncek, Monica C Panelli, Francesco M Marincola

Published in: Journal of Translational Medicine | Issue 1/2006

Abstract

Experimentally, interleukin-2 (IL-2) exerts complex immunological functions promoting the proliferation, survival and activation of T cells on one hand and inducing immune regulatory mechanisms on the other. This complexity results from a cross talk among immune cells which sways the effects of IL-2 according to the experimental or clinical condition tested. Recombinant IL-2 (rIL-2) stimulation of peripheral blood mononuclear cells (PBMC) from 47 donors of different genetic background induced generalized T cell activation and anti-apoptotic effects. Most effects were dependent upon interactions among immune cells. Specialized functions of CD4 and CD8 T cells were less dependent upon and often dampened by the presence of other PBMC populations. In particular, cytotoxic T cell effector function was variably affected with a component strictly dependent upon the direct stimulation of CD8 T cells in the absence of other PBMC. This observation may provide a roadmap for the interpretation of the discrepant biological activities of rIL-2 observed in distinct pathological conditions or treatment modalities.

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Title: Molecular signatures induced by interleukin-2 on peripheral blood mononuclear cells and T cell subsets
Authors: Ping Jin
Ena Wang
Maurizio Provenzano
Sara Deola
Silvia Selleri
Jiaqiang Ren
Sonia Voiculescu
David Stroncek
Monica C Panelli
Francesco M Marincola
Publication date: 01-06-2006
Publisher: BioMed Central
Published in: Journal of Translational Medicine / Issue 1/2006
Electronic ISSN: 1479-5876
DOI: https://doi.org/10.1186/1479-5876-4-26

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