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memo - Magazine of European Medical Oncology
Published in: memo - Magazine of European Medical Oncology 4/2016

01-12-2016 | short review

Molecular pathogenesis of chronic myeloid leukemia

Author: Gerald Webersinke

Published in: memo - Magazine of European Medical Oncology | Issue 4/2016

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Summary

Chronic myeloid leukemia (CML) is a paradigm for effective targeted therapy and is characterized by the hallmark BCR-ABL1 fusion. Although survival of affected patients has dramatically increased with the introduction of tyrosine kinase inhibitor therapy, kinase-dependent and -independent resistance mechanisms remain a problem and therefore new clinical strategies based on our growing knowledge of cellular processes are required. New diagnostic opportunities support this task and will change disease management in the future.
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Metadata
Title
Molecular pathogenesis of chronic myeloid leukemia
Author
Gerald Webersinke
Publication date
01-12-2016
Publisher
Springer Vienna
Published in
memo - Magazine of European Medical Oncology / Issue 4/2016
Print ISSN: 1865-5041
Electronic ISSN: 1865-5076
DOI
https://doi.org/10.1007/s12254-016-0294-0

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