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European Journal of Nuclear Medicine and Molecular Imaging

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Open Access 04-07-2022 | Molecular Imaging | Review Article

Optical molecular imaging and theranostics in neurological diseases based on aggregation-induced emission luminogens

Authors: Peili Cen, Youyou Zhou, Chunyi Cui, Yen Wei, Zhen Cheng, Shuizhu Wu, Hong Zhang, Mei Tian

Published in: European Journal of Nuclear Medicine and Molecular Imaging | Issue 13/2022

Abstract

Optical molecular imaging and image-guided theranostics benefit from special and specific imaging agents, for which aggregation-induced emission luminogens (AIEgens) have been regarded as good candidates in many biomedical applications. They display a large Stokes shift, high quantum yield, good biocompatibility, and resistance to photobleaching. Neurological diseases are becoming a substantial burden on individuals and society that affect over 50 million people worldwide. It is urgently needed to explore in more detail the brain structure and function, learn more about pathological processes of neurological diseases, and develop more efficient approaches for theranostics. Many AIEgens have been successfully designed, synthesized, and further applied for molecular imaging and image-guided theranostics in neurological diseases such as cerebrovascular disease, neurodegenerative disease, and brain tumor, which help us understand more about the pathophysiological state of brain through noninvasive optical imaging approaches. Herein, we focus on representative AIEgens investigated on brain vasculature imaging and theranostics in neurological diseases including cerebrovascular disease, neurodegenerative disease, and brain tumor. Considering different imaging modalities and various therapeutic functions, AIEgens have great potential to broaden neurological research and meet urgent needs in clinical practice. It will be inspiring to develop more practical and versatile AIEgens as molecular imaging agents for preclinical and clinical use on neurological diseases.

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Title: Optical molecular imaging and theranostics in neurological diseases based on aggregation-induced emission luminogens
Authors: Peili Cen
Youyou Zhou
Chunyi Cui
Yen Wei
Zhen Cheng
Shuizhu Wu
Hong Zhang
Mei Tian
Publication date: 04-07-2022
Publisher: Springer Berlin Heidelberg
Keywords: Molecular Imaging
Brain Tumor
Published in: European Journal of Nuclear Medicine and Molecular Imaging / Issue 13/2022
Print ISSN: 1619-7070
Electronic ISSN: 1619-7089
DOI: https://doi.org/10.1007/s00259-022-05894-7

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Springer Medicine

Optical molecular imaging and theranostics in neurological diseases based on aggregation-induced emission luminogens

Abstract

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

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