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Current Breast Cancer Reports
Published in: Current Breast Cancer Reports 3/2014

01-09-2014 | Translational Research (V Stearns, Section Editor)

Molecular Heterogeneity of Triple-Negative Breast Cancer

Authors: Vandana G. Abramson, Ingrid A. Mayer

Published in: Current Breast Cancer Reports | Issue 3/2014

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Abstract

Triple-negative breast cancers (TNBCs) are a group of aggressive breast cancers with a greater incidence of relapse, stage-for-stage, than ER/PR-positive and HER2-positive breast cancers, despite optimum loco-regional and systemic therapy. To date, no single targeted therapy has been approved for treatment of TNBC, and cytotoxic chemotherapy remains the standard systemic treatment. Recently, gene expression analysis identified six distinct TNBC subtypes, each with unique biology. In this review we discuss current and forthcoming therapeutic strategies and novel approaches to targeted treatment of these TNBC subtypes.
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Metadata
Title
Molecular Heterogeneity of Triple-Negative Breast Cancer
Authors
Vandana G. Abramson
Ingrid A. Mayer
Publication date
01-09-2014
Publisher
Springer US
Published in
Current Breast Cancer Reports / Issue 3/2014
Print ISSN: 1943-4588
Electronic ISSN: 1943-4596
DOI
https://doi.org/10.1007/s12609-014-0152-1

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