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01-07-2018 | Brief Report

Molecular evidence of JAK2 p.V617F mutated pure erythroid leukemia arising from polycythemia vera

Authors: Alisha D. Ware, Jacqueline Birkness, Amy S. Duffield, Christopher D. Gocke

Published in: Virchows Archiv | Issue 1/2018

Excerpt

Pure erythroid leukemia (PEL) is an uncommon subtype of acute myeloid leukemia (AML) [7, 8, 13, 15]. While AML is recognized as a complication of polycythemia vera (PV) [10‐12], there are few reports of PV transformation to PEL [1‐4, 6, 8, 9]. Five reported cases of PEL arising from PV, diagnosed between 1956 and 1962, followed therapy with radioactive phosphorus (³²P) [1, 4, 6, 9]. There were two case reports of transformation following therapy with hydroxyurea, in 1998 and 2012 [2, 3]. More recently, transformation to PEL and erythroid sarcoma in patients with long-standing PV treated with phlebotomy and hydroxyurea was described [5]. Here, we report molecular evidence of an unusual case of PEL with osseous involvement arising in a patient with known JAK2 V617F-positive PV. …

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Title: Molecular evidence of JAK2 p.V617F mutated pure erythroid leukemia arising from polycythemia vera
Authors: Alisha D. Ware
Jacqueline Birkness
Amy S. Duffield
Christopher D. Gocke
Publication date: 01-07-2018
Publisher: Springer Berlin Heidelberg
Published in: Virchows Archiv / Issue 1/2018
Print ISSN: 0945-6317
Electronic ISSN: 1432-2307
DOI: https://doi.org/10.1007/s00428-018-2347-8

2024 ASCO Annual Meeting

Springer Medicine

Molecular evidence of JAK2 p.V617F mutated pure erythroid leukemia arising from polycythemia vera

Excerpt

2024 ASCO Annual Meeting

Springer Medicine

Excerpt

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