Skip to main content
Top
Published in: Journal of Neural Transmission 12/2010

01-12-2010 | Basic Neurosciences, Genetics and Immunology - Rapid Communication

Molecular correlates of spontaneous activity in non-human primates

Authors: Amanda C. Mitchell, Georgina Aldridge, Shawn Kohler, Greg Stanton, Elinor Sullivan, Krassimira Garbett, Gabor Faludi, Károly Mirnics, Judy L. Cameron, William Greenough

Published in: Journal of Neural Transmission | Issue 12/2010

Login to get access

Abstract

In our monkey model, cortical ARC and BDNF expressions were strongly correlated with spontaneous physical activity. The expressions of ARC and BDNF were inversely correlated with serum CRP levels, suggesting that CRP could be a putative peripheral marker of brain resiliency.
Literature
go back to reference Arion D, Sabatini M, Unger T, Pastor J, Alonso-Nanclares L, Ballesteros-Yanez I, Garcia Sola R, Munoz A, Mirnics K, DeFelipe J (2006) Correlation of transcriptome profile with electrical activity in temporal lobe epilepsy. Neurobiol Dis 22:374–387PubMedCrossRef Arion D, Sabatini M, Unger T, Pastor J, Alonso-Nanclares L, Ballesteros-Yanez I, Garcia Sola R, Munoz A, Mirnics K, DeFelipe J (2006) Correlation of transcriptome profile with electrical activity in temporal lobe epilepsy. Neurobiol Dis 22:374–387PubMedCrossRef
go back to reference Arion D, Unger T, Lewis DA, Levitt P, Mirnics K (2007) Molecular evidence for increased expression of genes related to immune and chaperone function in the prefrontal cortex in schizophrenia. Biol Psychiatry 62:711–721PubMedCrossRef Arion D, Unger T, Lewis DA, Levitt P, Mirnics K (2007) Molecular evidence for increased expression of genes related to immune and chaperone function in the prefrontal cortex in schizophrenia. Biol Psychiatry 62:711–721PubMedCrossRef
go back to reference Carro E, Nunez A, Busiguina S, Torres-Aleman I (2000) Circulating insulin-like growth factor I mediates effects of exercise on the brain. J Neurosci 20:2926–2933PubMed Carro E, Nunez A, Busiguina S, Torres-Aleman I (2000) Circulating insulin-like growth factor I mediates effects of exercise on the brain. J Neurosci 20:2926–2933PubMed
go back to reference Carro E, Trejo JL, Busiguina S, Torres-Aleman I (2001) Circulating insulin-like growth factor I mediates the protective effects of physical exercise against brain insults of different etiology and anatomy. J Neurosci 21:5678–5684PubMed Carro E, Trejo JL, Busiguina S, Torres-Aleman I (2001) Circulating insulin-like growth factor I mediates the protective effects of physical exercise against brain insults of different etiology and anatomy. J Neurosci 21:5678–5684PubMed
go back to reference Chen J, Sochivko D, Beck H, Marechal D, Wiestler OD, Becker AJ (2001) Activity-induced expression of common reference genes in individual CNS neurons. Lab Invest 81:913–916PubMed Chen J, Sochivko D, Beck H, Marechal D, Wiestler OD, Becker AJ (2001) Activity-induced expression of common reference genes in individual CNS neurons. Lab Invest 81:913–916PubMed
go back to reference Church TS, Earnest CP, Thompson AM, Priest E, Rodarte RQ, Sanders T, Ross R and Blair SN (2009) Exercise without weight loss does not reduce C-reactive protein: the INFLAME study. Med Sci Sports Exerc 42(4):708–716 Church TS, Earnest CP, Thompson AM, Priest E, Rodarte RQ, Sanders T, Ross R and Blair SN (2009) Exercise without weight loss does not reduce C-reactive protein: the INFLAME study. Med Sci Sports Exerc 42(4):708–716
go back to reference De Pablos V, Barcia C, Martínez S, Gomez A, Ros-Bernal F, Zamarro-Parra J, Soria-Torrecillas JJ, Hernández J, Ceron JJ, Herrero MT (2009) MPTP administration increases plasma levels of acute phase proteins in non-human primates (Macaca fascicularis). Neurosci Lett 463(1):37–39PubMedCrossRef De Pablos V, Barcia C, Martínez S, Gomez A, Ros-Bernal F, Zamarro-Parra J, Soria-Torrecillas JJ, Hernández J, Ceron JJ, Herrero MT (2009) MPTP administration increases plasma levels of acute phase proteins in non-human primates (Macaca fascicularis). Neurosci Lett 463(1):37–39PubMedCrossRef
go back to reference Futterman LG, Lemberg L (2002) High-sensitivity C-reactive protein is the most effective prognostic measurement of acute coronary events. Am J Crit Care 11:482–486PubMed Futterman LG, Lemberg L (2002) High-sensitivity C-reactive protein is the most effective prognostic measurement of acute coronary events. Am J Crit Care 11:482–486PubMed
go back to reference Gill R, Kemp JA, Sabin C, Pepys MB (2004) Human C-reactive protein increases cerebral infarct size after middle cerebral artery occlusion in adult rats. J Cereb Blood Flow Metab 24(11):1214–1218PubMedCrossRef Gill R, Kemp JA, Sabin C, Pepys MB (2004) Human C-reactive protein increases cerebral infarct size after middle cerebral artery occlusion in adult rats. J Cereb Blood Flow Metab 24(11):1214–1218PubMedCrossRef
go back to reference Grinevich V, Kolleker A, Eliava M, Takada N, Takuma H, Fukazwa Y, Shigemoto R, Kuhl D, Waters J, Seeburg PH, Osten P (2009) Fluoresecent Arc/Arg3.1 indicator mice: a versatile tool to study brain activity changes in vitro and in vivo. J Neurosci Methods 184(1):25–36PubMedCrossRef Grinevich V, Kolleker A, Eliava M, Takada N, Takuma H, Fukazwa Y, Shigemoto R, Kuhl D, Waters J, Seeburg PH, Osten P (2009) Fluoresecent Arc/Arg3.1 indicator mice: a versatile tool to study brain activity changes in vitro and in vivo. J Neurosci Methods 184(1):25–36PubMedCrossRef
go back to reference Hofer M, Pagliusi SR, Hohn A, Leibrok J, Barde YA (1990) Regional distribution of brain-derived neurotrophic factor in mRNA in the adult mouse brain. EMBO 9(8):2459–2464 Hofer M, Pagliusi SR, Hohn A, Leibrok J, Barde YA (1990) Regional distribution of brain-derived neurotrophic factor in mRNA in the adult mouse brain. EMBO 9(8):2459–2464
go back to reference Hu FB, Stampfer MJ, Colditz GA, Ascherio A, Rexrode KM, Willett WC, Manson JC (2000) Physical activity and risk of stroke in women. JAMA 283:2961–2967PubMedCrossRef Hu FB, Stampfer MJ, Colditz GA, Ascherio A, Rexrode KM, Willett WC, Manson JC (2000) Physical activity and risk of stroke in women. JAMA 283:2961–2967PubMedCrossRef
go back to reference Kuhlmann CR, Librizzi L, Closhen D, Pflanzner T, Lessmann V, Pietrzik CU, de Curtis M, Luhmann HJ (2009) Mechanisms of C-reactive protein-induced blood–brain barrier disruption. Stroke 40(4):1458–1466PubMedCrossRef Kuhlmann CR, Librizzi L, Closhen D, Pflanzner T, Lessmann V, Pietrzik CU, de Curtis M, Luhmann HJ (2009) Mechanisms of C-reactive protein-induced blood–brain barrier disruption. Stroke 40(4):1458–1466PubMedCrossRef
go back to reference Lakka TA, Lakka HM, Rankinen T, Leon AS, Rao DC, Skinner JS, Wilmore JH, Bouchard C (2005) Effect of exercise training on serum levels of C-reactive protein in healthy individuals: the heritage family study. Eur Heart J 26:2018–2025PubMedCrossRef Lakka TA, Lakka HM, Rankinen T, Leon AS, Rao DC, Skinner JS, Wilmore JH, Bouchard C (2005) Effect of exercise training on serum levels of C-reactive protein in healthy individuals: the heritage family study. Eur Heart J 26:2018–2025PubMedCrossRef
go back to reference Larson EB, Wang L, Bowen JD, McCormick WC, Teri L, Crane P, Kukull W (2006) Exercise is associated with reduced risk for incident dementia among persons 65 years of age and older. Ann Intern Med 144(2):73–81PubMed Larson EB, Wang L, Bowen JD, McCormick WC, Teri L, Crane P, Kukull W (2006) Exercise is associated with reduced risk for incident dementia among persons 65 years of age and older. Ann Intern Med 144(2):73–81PubMed
go back to reference Lawlor A, Hopker SW (2001) The effectiveness of exercise as an intervention in the management of depression: systematic review and meta-regression analysis of randomised controlled trials. BMJ 322:763–767PubMedCrossRef Lawlor A, Hopker SW (2001) The effectiveness of exercise as an intervention in the management of depression: systematic review and meta-regression analysis of randomised controlled trials. BMJ 322:763–767PubMedCrossRef
go back to reference Lazarov O, Robinson J, Tang YP, Hairston IS, Korade-Mirnics Z, Lee VM, Hersh LB, Sapolsky RM, Mirnics K, Sisodia SS (2005) Environmental enrichment reduces Aβ levels and amyloid deposition in transgenic mice. Cell 120:701–713PubMedCrossRef Lazarov O, Robinson J, Tang YP, Hairston IS, Korade-Mirnics Z, Lee VM, Hersh LB, Sapolsky RM, Mirnics K, Sisodia SS (2005) Environmental enrichment reduces Aβ levels and amyloid deposition in transgenic mice. Cell 120:701–713PubMedCrossRef
go back to reference Lee IM, Paffenbarger RS (1998) Physical activity and stroke incidence. The harvard alumni health study. Stroke 29:2049–2054PubMed Lee IM, Paffenbarger RS (1998) Physical activity and stroke incidence. The harvard alumni health study. Stroke 29:2049–2054PubMed
go back to reference Link W, Konietzko U, Kauselmann G, Krugt M, Schwanke B, Freys U, Kuhl D (1995) Somatodendritic expression of an immediate early gene is regulated by synaptic activity. Proc Natl Acad Sci USA 92:5734–5738PubMedCrossRef Link W, Konietzko U, Kauselmann G, Krugt M, Schwanke B, Freys U, Kuhl D (1995) Somatodendritic expression of an immediate early gene is regulated by synaptic activity. Proc Natl Acad Sci USA 92:5734–5738PubMedCrossRef
go back to reference Marwick TH, Hordern MD, Miller T, Chyun DA, Bertoni AG, Blumenthal RS, Philippides G, Rocchini A (2009) Council on Clinical Cardiology, American Heart Association Exercise, Cardiac Rehabilitation, and Prevention Committee; Council on Cardiovascular Disease in the Young; Council on Cardiovascular Nursing; Council on Nutrition, Physical Activity, and Metabolism; and Interdisciplinary Council on Quality of Care and Outcomes Research Exercise training for type 2 diabetes mellitus: impact on cardiovascular risk: a scientific statement from the American Heart Association. Circulation 119(25):3244–3262PubMedCrossRef Marwick TH, Hordern MD, Miller T, Chyun DA, Bertoni AG, Blumenthal RS, Philippides G, Rocchini A (2009) Council on Clinical Cardiology, American Heart Association Exercise, Cardiac Rehabilitation, and Prevention Committee; Council on Cardiovascular Disease in the Young; Council on Cardiovascular Nursing; Council on Nutrition, Physical Activity, and Metabolism; and Interdisciplinary Council on Quality of Care and Outcomes Research Exercise training for type 2 diabetes mellitus: impact on cardiovascular risk: a scientific statement from the American Heart Association. Circulation 119(25):3244–3262PubMedCrossRef
go back to reference Mimmack ML, Brooking J, Bahn S (2004) Quantitative polymerase chain reaction: validation of microarray results from postmortem brain studies. Biol Psychiatry 55:337–345PubMedCrossRef Mimmack ML, Brooking J, Bahn S (2004) Quantitative polymerase chain reaction: validation of microarray results from postmortem brain studies. Biol Psychiatry 55:337–345PubMedCrossRef
go back to reference Molteni R, Ying Z, Gómez-Pinilla F (2002) Differential effects of acute and chronic exercise on plasticity-related genes in the rat hippocampus revealed by microarray. Eur J Neurosci 16(6):1107–1116PubMedCrossRef Molteni R, Ying Z, Gómez-Pinilla F (2002) Differential effects of acute and chronic exercise on plasticity-related genes in the rat hippocampus revealed by microarray. Eur J Neurosci 16(6):1107–1116PubMedCrossRef
go back to reference Neeper SA, Gomez-Pinilla F, Choi J, Cotman CW (1996) Physical activity increases mRNA for brain-derived neurotrophic factor and nerve growth factor in rat brain. Brain Res 726(1–2):49–56PubMedCrossRef Neeper SA, Gomez-Pinilla F, Choi J, Cotman CW (1996) Physical activity increases mRNA for brain-derived neurotrophic factor and nerve growth factor in rat brain. Brain Res 726(1–2):49–56PubMedCrossRef
go back to reference Phillips HS, Hains JM, Laramee GR, Rosenthal A, Winslow JW (1990) Widespread expression of BDNF, but not NT3 by target areas of basal forebrain cholinergic neurons. Science 250(4978):290–294PubMedCrossRef Phillips HS, Hains JM, Laramee GR, Rosenthal A, Winslow JW (1990) Widespread expression of BDNF, but not NT3 by target areas of basal forebrain cholinergic neurons. Science 250(4978):290–294PubMedCrossRef
go back to reference Rhyu IJ, Boklewski J, Ferguson B, Lee KJ, Lange H, Bytheway J, Cameron J (2003) Exercise training is associated with increased cortical vascularization in adult female cynomolgus monkeys. Soc Neurosci Abst 29:920–921 Rhyu IJ, Boklewski J, Ferguson B, Lee KJ, Lange H, Bytheway J, Cameron J (2003) Exercise training is associated with increased cortical vascularization in adult female cynomolgus monkeys. Soc Neurosci Abst 29:920–921
go back to reference Shadoan MK, Anthony MS, Rankin SE, Clarkson TB, Wagner JD (2003) Effects of tibolone and conjugated equine estrogens with or without medroxyprogesterone acetate on body composition and fasting carbohydrate measures in surgically postmenopausal monkeys. Metabolism 52(9):1085–1091PubMedCrossRef Shadoan MK, Anthony MS, Rankin SE, Clarkson TB, Wagner JD (2003) Effects of tibolone and conjugated equine estrogens with or without medroxyprogesterone acetate on body composition and fasting carbohydrate measures in surgically postmenopausal monkeys. Metabolism 52(9):1085–1091PubMedCrossRef
go back to reference Stenvinkel P (2006) C-reactive protein––does it promote vascular disease? Nephrol Dial Transplant 21:2718–2720PubMedCrossRef Stenvinkel P (2006) C-reactive protein––does it promote vascular disease? Nephrol Dial Transplant 21:2718–2720PubMedCrossRef
go back to reference Steward O, Worley P (2002) Local synthesis of proteins at synaptic sites on dendrites: role in synaptic plasticity and memory consolidation? Neurobiol Learn Mem 78:508–527PubMedCrossRef Steward O, Worley P (2002) Local synthesis of proteins at synaptic sites on dendrites: role in synaptic plasticity and memory consolidation? Neurobiol Learn Mem 78:508–527PubMedCrossRef
go back to reference Stewart LK, Earnest CP, Blair SN, Church TS (2009) Effects of different doses of physical activity on C-reactive protein among women. Med Sci Sports Exerc 93(2):221–225 Stewart LK, Earnest CP, Blair SN, Church TS (2009) Effects of different doses of physical activity on C-reactive protein among women. Med Sci Sports Exerc 93(2):221–225
go back to reference Sullivan EL, Cameron JL (2010) A rapidly occuring compensatory decrease in physical activity counteracts diet-induced weight loss in female monkeys. Am J Physiol Regul Integr Comp Physiol 298(4):R1068–R1074PubMed Sullivan EL, Cameron JL (2010) A rapidly occuring compensatory decrease in physical activity counteracts diet-induced weight loss in female monkeys. Am J Physiol Regul Integr Comp Physiol 298(4):R1068–R1074PubMed
go back to reference Sullivan EL, Koegler FH, Cameron JL (2006) Individual differences in physical activity are closely associated with changes in body weight in adult female rhesus monkeys (Macaca mulatta). Am J Physiol Regul Integr Comp Physiol 291(3):R633–R642PubMed Sullivan EL, Koegler FH, Cameron JL (2006) Individual differences in physical activity are closely associated with changes in body weight in adult female rhesus monkeys (Macaca mulatta). Am J Physiol Regul Integr Comp Physiol 291(3):R633–R642PubMed
go back to reference Thacker EL, Chen H, Patel AV, McCullough ML, Calle EL, Thun MJ, Schwarzschild MA, Ascherio A (2008) Recreational physical activity and risk of Parkinson’s disease. Mov Disord 23(1):69–74PubMedCrossRef Thacker EL, Chen H, Patel AV, McCullough ML, Calle EL, Thun MJ, Schwarzschild MA, Ascherio A (2008) Recreational physical activity and risk of Parkinson’s disease. Mov Disord 23(1):69–74PubMedCrossRef
go back to reference Tong L, Shen H, Perreau VM, Balazs R, Cotman CW (2001) Effects of exercise on gene-expression profile in the rat hippocampus. Neurobiol Dis 8(6):1046–1056PubMedCrossRef Tong L, Shen H, Perreau VM, Balazs R, Cotman CW (2001) Effects of exercise on gene-expression profile in the rat hippocampus. Neurobiol Dis 8(6):1046–1056PubMedCrossRef
go back to reference Vance DE, Wadley VG, Ball KK, Roenker DL, Rizzo M (2005) The effects of physical activity and sedentary behavior on cognitive health in older adults. J Aging Phys Act 13(3):294–313PubMed Vance DE, Wadley VG, Ball KK, Roenker DL, Rizzo M (2005) The effects of physical activity and sedentary behavior on cognitive health in older adults. J Aging Phys Act 13(3):294–313PubMed
go back to reference Vazdarjanova A, Ramirez-Amaya V, Insel N, Plummer TK, Rosi S, Chowdhury S, Mikhael D, Worley PF, Guzowski JF, Barnes CA (2006) Spatial exploration induces ARC, a plasticity-related immediate-early gene, only in calcium/calmodulin-dependent protein kinase II-positive principal excitatory and inhibitory neurons of the rat forebrain. J Comp Neurol 498(3):317–329PubMedCrossRef Vazdarjanova A, Ramirez-Amaya V, Insel N, Plummer TK, Rosi S, Chowdhury S, Mikhael D, Worley PF, Guzowski JF, Barnes CA (2006) Spatial exploration induces ARC, a plasticity-related immediate-early gene, only in calcium/calmodulin-dependent protein kinase II-positive principal excitatory and inhibitory neurons of the rat forebrain. J Comp Neurol 498(3):317–329PubMedCrossRef
go back to reference Volanakis JE, Kaplan MH (1971) Specificity of C-reactive protein for choline phosphate residues of pneumococcal C-polysaccharide. Proc Soc Exp Biol Med 136(2):612–614PubMed Volanakis JE, Kaplan MH (1971) Specificity of C-reactive protein for choline phosphate residues of pneumococcal C-polysaccharide. Proc Soc Exp Biol Med 136(2):612–614PubMed
go back to reference Volk DW, Austin MC, Pierri JN, Sampson AR, Lewis DA (2000) Decreased glutamic acid decarboxylase67 messenger rNA expression in a subset of prefrontal cortical gamma-aminobutyric acid neurons in subjects with schizophrenia. Arch Gen Psychiatry 57:237–245PubMedCrossRef Volk DW, Austin MC, Pierri JN, Sampson AR, Lewis DA (2000) Decreased glutamic acid decarboxylase67 messenger rNA expression in a subset of prefrontal cortical gamma-aminobutyric acid neurons in subjects with schizophrenia. Arch Gen Psychiatry 57:237–245PubMedCrossRef
go back to reference Wang Q, Zhu X, Xu Q, Ding X, Chen YE, Song Q (2005) Effect of C-reactive protein on gene expression in vascular endothelial cells. Am J Physiol Heart Circ Physiol 288:H1539–H1545PubMedCrossRef Wang Q, Zhu X, Xu Q, Ding X, Chen YE, Song Q (2005) Effect of C-reactive protein on gene expression in vascular endothelial cells. Am J Physiol Heart Circ Physiol 288:H1539–H1545PubMedCrossRef
go back to reference Williams K, Sniderman AD, Sattar N, D’Agostino R Jr, Wagenknecht LE, Haffner SM (2003) Comparison of the associations of apolipoprotein B and low-density lipoprotein cholesterol with other cardiovascular risk factors in the insulin resistance atherosclerosis study (IRAS). Circulation 108(19):2312–2316PubMedCrossRef Williams K, Sniderman AD, Sattar N, D’Agostino R Jr, Wagenknecht LE, Haffner SM (2003) Comparison of the associations of apolipoprotein B and low-density lipoprotein cholesterol with other cardiovascular risk factors in the insulin resistance atherosclerosis study (IRAS). Circulation 108(19):2312–2316PubMedCrossRef
go back to reference Yaffe K, Barnes D, Nevitt M, Lui LY, Covinsky K (2001) A prospective study of physical and cognitive decline in elderly women: women who walk. Arch Intern Med 161(14):1703–1708PubMedCrossRef Yaffe K, Barnes D, Nevitt M, Lui LY, Covinsky K (2001) A prospective study of physical and cognitive decline in elderly women: women who walk. Arch Intern Med 161(14):1703–1708PubMedCrossRef
go back to reference Zhang HT, Li LY, Zou XL, Song XB, Hu YL, Feng ZT, Wang TT (2007) Immunohistochemical distribution of NGF, BDNF, NT-3, and NT-4 in adult rhesus monkey brains. J Histochem Cytochem 55(1):1–19PubMedCrossRef Zhang HT, Li LY, Zou XL, Song XB, Hu YL, Feng ZT, Wang TT (2007) Immunohistochemical distribution of NGF, BDNF, NT-3, and NT-4 in adult rhesus monkey brains. J Histochem Cytochem 55(1):1–19PubMedCrossRef
Metadata
Title
Molecular correlates of spontaneous activity in non-human primates
Authors
Amanda C. Mitchell
Georgina Aldridge
Shawn Kohler
Greg Stanton
Elinor Sullivan
Krassimira Garbett
Gabor Faludi
Károly Mirnics
Judy L. Cameron
William Greenough
Publication date
01-12-2010
Publisher
Springer Vienna
Published in
Journal of Neural Transmission / Issue 12/2010
Print ISSN: 0300-9564
Electronic ISSN: 1435-1463
DOI
https://doi.org/10.1007/s00702-010-0483-7

Other articles of this Issue 12/2010

Journal of Neural Transmission 12/2010 Go to the issue

Basic Neurosciences, Genetics and Immunology - Review Article

Postsynaptic nigrostriatal dopamine receptors and their role in movement regulation