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Journal of Assisted Reproduction and Genetics

Published in:

01-06-2011 | Special IVM Issue

Molecular characterization of the human ovulatory cascade—Lesson from the IVF/IVM model

Authors: Gil M. Yerushalmi, Ettie Maman, Yuval Yung, Alon Kedem, Ariel Hourvitz

Published in: Journal of Assisted Reproduction and Genetics | Issue 6/2011

Abstract

Aims

Ovarian follicular development and ovulation in mammals is a complex and highly regulated process. Most advances in the understanding of the ovulatory process have come from animal models. However, translational research in humans is of crucial importance for improving fertility treatment and control.

Methods

IVM/IVF procedures allow us to obtain follicular fluid and granulosa cells (GC) from follicles in different developmental stages with and without hCG priming.

Results

Using the cells and fluids obtained in IVM/IVF procedures allowed us to characterize human ovulatory gene expression during antral folliculogenesis and ovulation, examine gene expression in luteinized and non-luteinized GC in vivo and in vitro and to use cumulus GC genes as biomarkers for oocyte and embryo maturity and competence.

Conclusion

Biological material obtained during IVM/IVF procedures is an important tool to study the human ovulatory cascade and can serve to improve IVM techniques and fertility treatment and control.

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Title: Molecular characterization of the human ovulatory cascade—Lesson from the IVF/IVM model
Authors: Gil M. Yerushalmi
Ettie Maman
Yuval Yung
Alon Kedem
Ariel Hourvitz
Publication date: 01-06-2011
Publisher: Springer US
Published in: Journal of Assisted Reproduction and Genetics / Issue 6/2011
Print ISSN: 1058-0468
Electronic ISSN: 1573-7330
DOI: https://doi.org/10.1007/s10815-011-9594-9

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Molecular characterization of the human ovulatory cascade—Lesson from the IVF/IVM model

Abstract

Aims

Methods

Results

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Aims

Methods

Results

Conclusion

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