Issue Special Issue 1/2015
Abstracts of the 51st Workshop for Pediatric Research
Content (30 Articles)
Novel orphan medicines and abandoned pathways - the US Orphan Drug Act of 1983 and the impact on rare rheumatologic diseases and lysosomal storage disorders
Markus Ries, Thomas Lutz, Anette Lampert, William Mountford, Konstantin Mechler, Georg F Hoffmann
A regulatory SNP modifies cystic fibrosis by disrupting NFκB complex binding on FAS
Chidiebere U Awah, Silke Hedtfeld, Burkhard Tümmler, Frauke Stanke
Functional genomic screening reveals asparagine dependence as a metabolic vulnerability in sarcoma
Simone Hettmer, Anna C Schinzel, Daria Tchessalova, Nigel Richards, William C Hahn, Amy J Wagers
Myeloid regulatory cells: cross talk of innate and adaptive immunity to maintain the intestinal immune homeostasis in inflammatory bowel disease
Jan Däbritz, Toni Weinhage, Georg Varga, Timo Wirth, Jan M Ehrchen, Louise M Judd, Trevelyan R Menheniott, Andrew S Giraud, Dirk Foell
Differential expression of mucosal trefoil factors and mucins in pediatric inflammatory bowel diseases
Andreas C Jenke, Veronika Boland, Jan Postberg, Silvia Vogel, Daniel Gödde, Matthias Zilbauer, Robert Heuschkel, Stefan Wirth, Kai O Hensel
Introduction of formula feeding induces subclinical inflammation and altered chromatin structure in the intestine of preterm pigs
Rhea Willems, Verena Rybicki, Pingping Jiang, Per Torp Sangild, René Liang Shen, Kai O Hensel, Stefan Wirth, Jan Postberg, Andreas C Jenke
Nexilin mutations are associated with left ventricular noncompaction cardiomyopathy
E Pardun, K Wenzel, H-H Kramer, F Berger, B Gerull, S Klaassen
Quantitative stress echocardiography in pediatric patients with type-1 diabetes mellitus
Kai O Hensel, Franziska Grimmer, Markus Roskopf, Andreas Heusch, Andreas Jenke, Stefan Wirth
Mutations in the NKX2.1 and the PAX8 genes in a boy with thyroid dysgenesis, respiratory and neurological disorders
Pia Hermanns, Małgorzata Kumorowicz-Czoch, Joachim Pohlenz
Integrated genomics elucidates relative spatial homogeneity of embryonal brain tumors
Marc Remke, Florence Cavalli, A Sorana Morrissy, Vijay Ramaswamy, David Jones, Roger Packer, Eric Bouffet, Gary Bader, Arndt Borkhardt, Stefan Pfister, Nada Jabado, Marco Marra, Michael D Taylor
Neuroprotection after infection-sensitized neonatal hypoxic-ischemic brain injury
Hemmen Sabir, Damjan Osredkar, Elke Maes, Thomas Wood, Marianne Thoresen
Singleton-Merten Syndrome: a rare autoimmune disorder caused by a specific IFIH1 mutation
I Buers, Y Nitschke, RC Hennekam, M MacDougall, C Lu, O Mamaeva, GI Rice, H Erlandsen, HG Kehl, H Thiele, P Nürnberg, W Höhne, YJ Crow, A Feigenbaum, F Rutsch
MYCN transcriptionally represses CD9 to trigger an invasion-metastasis cascade in neuroblastoma
Johannes Fabian, Desirée Opitz, Kristina Althoff, Marco Lodrini, Kathy Astrahantseff, Barbara Hero, Ruth Volland, Anneleen Beckers, Katleen de Preter, Nitin S Patil, Mohammed L Abba, Theresa M Thole, Jasmin Wünschel, Annette Künkele, Jamie Hu, Leonille Schweizer, Gunhild Mechtersheimer, Daniel R Carter, Belamy B Cheung, Odilia Popanda, Andreas von Deimling, Kai-Oliver Henrich, Frank Westermann, Manfred Schwab, Jan Koster, Rogier Versteeg, Glenn M Marshall, Frank Speleman, Margot Zoeller, Heike Allgayer, Matthias Fischer, Frank Berthold, Andreas E Kulozik, Olaf Witt, Angelika Eggert, Johannes H Schulte, Hedwig E Deubzer
Impact of embryonic Fgf10 expression deficiency on embryonic mouse lung development and repair following hyperoxia injury
CM Chao, D Al Alam, S Schermuly, H Ehrhardt, KP Zimmer, S Bellusci
Mutations in CCNO and MCIDAS lead to a mucociliary clearance disorder due to reduced generation of multiple motile cilia
J Wallmeier, M Boon, D Al Mutairi, NT Loges, L Ma, C-T Chen, H Olbrich, P Pennekamp, T Menchen, G Dougherty, C Werner, M Jaspers, M Griese, E Horak, C Körner-Rettberg, S Schmitt-Grohé, T Zimmermann, A Hevroni, R Abitbul, A Avital, R Soferman, I Amirav, H Mitchison, M Jorissen, F Alkuraya, C Kintner, H Omran
Modern chronic heart failure therapy in context of pulmonary banding to avoid heart transplantation
S Recla, B Steinbrenner, T Logeswaran, L Rüblinger, D Schmidt, J Bauer, C Apitz, J Thul, D Schranz
Is the implementation of a microbiological surveillance screening beneficial in a neonatal intensive care unit?
I Schmeh, A Welk, T Schwanz, A Diefenbach, B Jansen, E Mildenberger
A potential role of PI3K inhibition in radiotherapy of glioblastoma multiforme
Julia Langhans, Lukas Schneele, Klaus-Michael Debatin, Mike-Andrew Westhoff
Regulation of PACAP receptors in respiratory distress syndrome (RDS) of preterms and newborns
MJ Müller, A Kislat, A Hippe, A Poppe, S Goldmann, T Paul, S Seeliger
Hypoxia potentiates cytotoxicity of LPS-activated microglial BV2 cells in vitro by synergistic effects on cytokine and nitric oxide secretion
Susan Jung, Daniel Frey, Florian Brackmann, Mandy Richter-Kraus, Regina Trollmann
Neutralization of interleukin-17 produced by gamma delta T cells constrains inflammation in experimental biliary atresia
Christian Klemann, Arne Schröder, Anika Dreier, Nora Moehn, Stephanie Dippel, Thomas Winterberg, Anne Wilde, Yi Yu, Faikah Gueler, Anne Joerns, Eva Tolosa, Johannes Leonhardt, Jan D Haas, Immo Prinz, Claus Petersen, Joachim F Kuebler
What we learned from bench to bedside with the neuroblastoma targeting CD171-specific CAR
A Künkele, AJ Johnson, C Berger, L Finn, J Park, MC Jensen
Disturbed B-lymphocytes selection in autoimmune lymphoproliferative syndrome
Aleš Janda, Klaus Schwarz, Mirjam van der Burg, Werner Vach, Hanna Ijspeert, Myriam Ricarda Lorenz, Magdeldin Elgizouli, Kathrin Pieper, Paul Fisch, Joachim Hagel, Raquel Lorenzetti, Maximilian Seidl, Joachim Roesler, Fabian Hauck, Elisabetta Traggiai, Carsten Speckmann, Anne Rensing-Ehl, Stephan Ehl, Hermann Eibel, Marta Rizzi
Identification of a putative new therapeutical target for Hodgkin's lymphoma
Stefanie Kewitz, Ines Volkmer, Martin S Staege
TMEM18 is a regulator of adipogenesis and involved in PPARG signalling in vivo
Kathrin Landgraf, Julian Schwartze, Denise Rockstroh, Wieland Kiess, Antje Körner
Fibrocystin in MDCK cells: impact on cell adhesion and epithelial morphogenesis
Birga Sötje, Dieter Haffner, Wolfgang H Ziegler
A translational approach to dystroglycanopathies: a frequent type of muscular dystrophy
Sebahattin Cirak, Haicui Wang, Raul Heredia, Francesco Muntoni, Yetrib Hathout, Peter Herkenrath, Jörg Dötsch, Peter Nürnberg
Simultaneously double infection of oncolytic viruses leads to addition of cell death induction in glioblastoma cell lines
Michael Ehrhardt, Julia Frank, Sigrun Smola, Norbert Graf
Cilia-associated cellular function of the AAA ATPases RUVBL1 and RUVBL2
Claudia Dafinger, Markus Rinschen, Carolin Ehrenberg, Mareike Franke, Heike Göbel, Jörg Dötsch, Thomas Benzing, Bernhard Schermer, Max Christoph Liebau
Pursuing novel molecular mechanisms and treatment strategies to enhance lung growth in neonatal chronic lung disease (CLD)
Miguel A Alejandre Alcazar, Mark Kaschwich, Stefanie Preuss, Robert Ertsey, Sana Mujahid, Eva Rother, Katharina Dinger, Jörg Dötsch, Marlene Rabinovitch, Richard Bland