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Open Access 01-06-2016 | Original Article

Molecular anatomy of the thalamic complex and the underlying transcription factors

Authors: Andrzej Nagalski, Luis Puelles, Michal Dabrowski, Tomasz Wegierski, Jacek Kuznicki, Marta B. Wisniewska

Published in: Brain Structure and Function | Issue 5/2016

Abstract

Thalamocortical loops have been implicated in the control of higher-order cognitive functions, but advances in our understanding of the molecular underpinnings of neocortical organization have not been accompanied by similar analyses in the thalamus. Using expression-based correlation maps and the manual mapping of mouse and human datasets available in the Allen Brain Atlas, we identified a few individual regions and several sets of molecularly related nuclei that partially overlap with the classic grouping that is based on topographical localization and thalamocortical connections. These new molecular divisions of the adult thalamic complex are defined by the combinatorial expression of Tcf7l2, Lef1, Gbx2, Prox1, Pou4f1, Esrrg, and Six3 transcription factor genes. Further in silico and experimental analyses provided the evidence that TCF7L2 might be a pan-thalamic specifier. These results provide substantial insights into the “molecular logic” that underlies organization of the thalamic complex.

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Title: Molecular anatomy of the thalamic complex and the underlying transcription factors
Authors: Andrzej Nagalski
Luis Puelles
Michal Dabrowski
Tomasz Wegierski
Jacek Kuznicki
Marta B. Wisniewska
Publication date: 01-06-2016
Publisher: Springer Berlin Heidelberg
Published in: Brain Structure and Function / Issue 5/2016
Print ISSN: 1863-2653
Electronic ISSN: 1863-2661
DOI: https://doi.org/10.1007/s00429-015-1052-5

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Molecular anatomy of the thalamic complex and the underlying transcription factors

Abstract

Keynote webinar | Spotlight on medication adherence

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Abstract

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