Skip to main content
Key Specialties
Cardiology Diabetology Endocrinology Gastroenterology Geriatrics and Gerontology Gynecology and Obstetrics Hematology Infectious Disease Internal Medicine Nephrology Neurology Oncology Pediatrics Respiratory Medicine Rheumatology Surgery
Congress Coverage
2024 ACC Congress 2023 ESMO Congress 2023 EASD Congress 2023 ERS Congress 2023 ESC Congress
Clinical Collections
Advances in Alzheimer’s

Keynote webinar | Spotlight on medication adherence

LIVE: Thursday 27th June 2024, 18:00-19:30 (CEST)
Join our expert panel to discover why you need to understand the drivers of non-adherence in your patients, and how you can optimize medication adherence in your clinics to drastically improve patient outcomes.
ADVANCED SEARCH
Log in
Top
BMC Oral Health
Published in: BMC Oral Health 1/2023

Open Access 01-12-2023 | Research

Molar-root incisor malformation — a systematic review of case reports and case series

Authors: Emilija D. Jensen, Gabrielle Smart, Brianna F. Poirier, Sneha Sethi

Published in: BMC Oral Health | Issue 1/2023

Login to get access

Abstract

Objectives

Molar-root incisor malformation (MRIM) is a seldom reported condition characterised by disturbances in root development of first permanent molars. This systematic review aimed to collate the clinical characteristics of individuals diagnosed with MRIM.

Materials and methods

A systematic search strategy using PubMed, Embase, Web of Science, and SCOPUS databases was performed through to March 2023. Inclusion criteria were case reports or case series including a diagnosis consistent with MRIM. Critical appraisal for all included studies utilised the Joanna Briggs Institute (JBI) critical appraisal checklist for case reports and case series and collation of clinical characteristics was performed in JBI System for the Unified Management, Assessment and Review of Information program.

Results

The search identified 157 studies from which 35 satisfied the inclusion criteria. After full-text review, a total of 23 papers described the MRIM dental anomaly and were included in this paper. A total of 130 reported cases were retrieved, with age ranging 3–32 years, and males affected 1.16:1 females. Presence of neurological conditions, premature birth history, medication, and surgery within first years of life were synthesised and described.

Conclusions

The aetiology of MRIM is yet to be determined but epigenetic changes from significant medical history in the first years of life are likely to influence the development of this root malformation. First permanent molars were most commonly affected, but clinicians should be aware that permanent central incisors, primary teeth and other permanent teeth may also be affected.
Appendix
Available only for authorised users
Literature
1.
Witt CVA, Hirt T, Rutz G, Luder HU. Root malformation associated with a cervical mineralized diaphragm–a distinct form of tooth abnormality? Oral Surg Oral Med Oral Pathol Oral Radiol. 2014;117(4):e311–9.CrossRefPubMed
2.
Lee H-S, Kim S-H, Kim S-O, Lee J-H, Choi H-J, Jung H-S, Song JS. A new type of dental anomaly: molar-incisor malformation (MIM). Oral Surg Oral Med Oral Pathol Oral Radiol. 2014;118(1):101–9. e103.CrossRefPubMed
3.
Wright JT, Curran A, Kim K-J, Yang Y-M, Nam S-H, Shin TJ, Hyun H-K, Kim Y-J, Lee S-H, Kim J-W. Molar root-incisor malformation: considerations of diverse developmental and etiologic factors. Oral Surg Oral Med Oral Pathol Oral Radiol. 2016;121(2):164–72.CrossRefPubMed
4.
Koch G, Thesleff Ia, Kreiborg S. Tooth development and disturbances in number and shape of teeth. Pediatr Dentistry—A Clin Approach 2009:183–96.
5.
Page MJ, McKenzie JE, Bossuyt PM, Boutron I, Hoffmann TC, Mulrow CD, Shamseer L, Tetzlaff JM, Akl EA, Brennan SE. The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. BMJ 2021, 372.
6.
Petticrew M, Roberts H. Systematic reviews in the social sciences: a practical guide. John Wiley & Sons; 2008.
7.
Moola S, Munn Z, Tufanaru C, Aromataris E, Sears K, Sfetcu R, Currie M, Qureshi R, Mattis P, Lisy K. Chap. 7: systematic reviews of etiology and risk. Joanna Briggs Institute Reviewer’s Manual The Joanna Briggs Institute 2017, 5.
8.
Brusevold IJ, Bie TMG, Baumgartner CS, Das R, Espelid I. Molar incisor malformation in six cases: description and diagnostic protocol. Oral Surg Oral Med Oral Pathol Oral Radiol. 2017;124(1):52–61.CrossRefPubMed
9.
Byun C, Kim C, Cho S, Baek SH, Kim G, Kim SG, Kim S-Y. Endodontic treatment of an anomalous anterior tooth with the aid of a 3-dimensional printed physical tooth model. J Endod. 2015;41(6):961–5.CrossRefPubMed
10.
Choi S, Lee J, Song J. Molar-incisor malformation: three cases of a newly identified dental anomaly. J Korean Acad Pediatr Dentistry. 2017;44(3):370–7.CrossRef
11.
Kim J-E, Hong J-K, Yi W-J, Heo M-S, Lee S-S, Choi S-C, Huh K-H. Clinico-radiologic features of molar-incisor malformation in a case series of 38 patients: A retrospective observational study. J Med 2019, 98(40).
12.
Kim MJ, Song J-S, Kim Y-J, Kim J-W, Jang K-T, Hyun H-K. Clinical considerations for dental management of children with molar-root incisor malformations. J Clin Pediatr Dent. 2020;44(1):55–9.CrossRefPubMed
13.
Lee H-S, Kim S-H, Kim S-O, Choi B-J, Cho S-W, Park W, Song JS. Microscopic analysis of molar–incisor malformation. Oral Surg Oral Med Oral Pathol Oral Radiol. 2015;119(5):544–52.CrossRefPubMed
14.
Lee H-S, Kim HJ, Lee K, Kim MS, Nam OH, Choi S-C. Complications of teeth affected by molar-incisor malformation and pathogenesis according to microbiome analysis. Appl Sci. 2021;11(1):4.CrossRef
15.
McCreedy C, Robbins H, Newell A, Mallya SM. Molar-incisor malformation: two cases of a newly described dental anomaly. J Dent Child (Chic). 2016;83(1):33–7.PubMed
16.
Neo H-LL, Watt EN, Acharya P. Molar-incisor malformation: a case report and clinical considerations. J Orthodont. 2019;46(4):343–8.CrossRef
17.
Park S, Byun S, Kim J, Yang B, Oh S. Treatment of Molar Incisor Malformation and the short term follow-up. Eur J Paediatr Dent. 2020;21(3):238–42.PubMed
18.
Pavlič A, Vrecl M, Jan J, Bizjak M, Nemec A. Case report of a molar-root incisor malformation in a patient with an autoimmune lymphoproliferative syndrome. BMC Oral Health. 2019;19(1):1–12.CrossRef
19.
Qari H, Kessler H, Narayana N, Premaraj S. Symmetric multiquadrant isolated dentin dysplasia (SMIDD), a unique presentation mimicking dentin dysplasia type 1b. Oral Surg Oral Med Oral Pathol Oral Radiol. 2017;123(5):e164–9.CrossRefPubMed
20.
Vargo RJ, Reddy R, Da Costa WB, Mugayar LRF, Islam MN, Potluri A. Molar-incisor malformation: eight new cases and a review of the literature. Int J Paediatr Dent. 2020;30(2):216–24.CrossRefPubMed
21.
de Fátima Vieira FG, Pintor AVB, Abrahão AC, de Oliveira Ruellas AC, Visconti MA, Primo LG. Differential diagnosis, three-dimensional imaging aspects and interceptive orthodontic management of molar–incisor malformation. Int J Case Rep Images. 2020;11:101099Z101001FV102020.
22.
Youssef MJ, Siegel DH, Chiu YE, Drolet BA, Hodgson BD. Dental root abnormalities in four children with PHACE syndrome. Pediatr Dermatol. 2019;36(4):505–8.CrossRefPubMedPubMedCentral
23.
Yue W, Kim E. Nonsurgical endodontic management of a molar-incisor malformation-affected mandibular first molar: a case report. J Endod. 2016;42(4):664–8.CrossRefPubMed
24.
Zschocke J, Schossig A, Bosshardt DD, Karall D, Glueckert R, Kapferer-Seebacher I. Variable expressivity of TCTEX1D2 mutations and a possible pathogenic link of molar-incisor malformation to ciliary dysfunction. Arch Oral Biol. 2017;80:222–8.CrossRefPubMed
25.
Jensen ED, Smart G, Lee N, Tan J, Oliver K, Ha WN, Ranjitkar S. Prevalence and morphological features of molar-root incisor malformation from a specialist pediatric dental unit. Int J Pediatr Dent 2023.
26.
Korte A, Angelopoulou MV, Yfanti K. Guidance for permanent first molar extraction in molar-incisor malformation: report of two cases. J Dent Child. 2022;89(1):29–35.
27.
Song J-S, Yang Y-M, Kim Y-J, Kim J-W. Management of severely aberrant permanent first molars in molar root–incisor malformation patients: case series and a guideline. Children. 2021;8(10):904.CrossRefPubMedPubMedCentral
28.
Brusevold IJ, Bie TMG, Baumgartner CS, Das R, Espelid I. Molar incisor malformation in six cases: description and diagnostic protocol. Oral Surg Oral Med. 2017;124(1):52–61.
29.
Lee H-S, Kim S-H, Kim S-O, Lee J-H, Choi H-J, Jung H-S, Song JS. A new type of dental anomaly: molar-incisor malformation (MIM). Oral Surg Oral Med. 2014;118(1):101–9.
30.
Vargo RJ, Reddy R, Da Costa WB, Mugayar LR, Islam MN, Potluri A. Molar-incisor malformation: eight new cases and a review of the literature. Int J Paediatr Dent. 2020;30(2):216–24.CrossRefPubMed
31.
Wright JT, Curran A, Kim K-J, Yang Y-M, Nam S-H, Shin TJ, Hyun H-K, Kim Y-J, Lee S-H, Kim J-W. Molar root-incisor malformation: considerations of diverse developmental and etiologic factors. Oral Surg Oral Med. 2016;121(2):164–72.
32.
Witt CVA, Hirt T, Rutz G, Luder HU. Root malformation associated with a cervical mineralized diaphragm–a distinct form of tooth abnormality? Oral Surg Oral Med. 2014;117(4):e311–9.
33.
Choi S, Lee J, Song J. Molar-incisor malformation: three cases of a newly identified dental anomaly. J Korean Acad Pediatr Dent. 2017;44(3):370–7.CrossRef
34.
Lee H-S, Kim S-H, Kim S-O, Choi B-J, Cho S-W, Park W, Song JS. Microscopic analysis of molar–incisor malformation. Oral Surg Oral Med. 2015;119(5):544–52.
35.
Crawford PJ, Aldred MJ. Regional odontodysplasia: a bibliography. J Oral Pathol Med. 1989;18(5):251–63.CrossRefPubMed
36.
Shields E, Bixler D, El-Kafrawy A. A proposed classification for heritable human dentine defects with a description of a new entity. Arch Oral Biol. 1973;18(4):543–IN547.CrossRefPubMed
37.
Pereira CM, de Andrade CR, Vargas PA, Della Coletta R, de Almeida OP, Lopes MA. Dental alterations associated with X-linked hypophosphatemic rickets. J Endod. 2004;30(4):241–5.CrossRefPubMed
38.
Morimoto M, Kérourédan O, Gendronneau M, Shuen C, Baradaran-Heravi A, Asakura Y, Basiratnia M, Bogdanovic R, Bonneau D, Buck A, et al. Dental abnormalities in Schimke immuno-osseous dysplasia. J Dent Res. 2012;91(7 Suppl):29S–37S.CrossRefPubMed
39.
Danforth RA, Melrose RJ, Abrams AM, Handlers JP. Segmental odontomaxillary dysplasia: report of eight cases and comparison with hemimaxillofacial dysplasia. Oral Surg Oral Med Oral Pathol Oral Radiol. 1990;70(1):81–5.CrossRef
40.
Hejlesen J, Underbjerg L, Gjørup H, Sikjaer T, Rejnmark L, Haubek D. Dental anomalies and orthodontic characteristics in patients with pseudohypoparathyroidism. BMC Oral Health. 2020;20(1):1–9.CrossRef
Metadata
Title
Molar-root incisor malformation — a systematic review of case reports and case series
Authors
Emilija D. Jensen
Gabrielle Smart
Brianna F. Poirier
Sneha Sethi
Publication date
01-12-2023
Publisher
BioMed Central
Published in
BMC Oral Health / Issue 1/2023
Electronic ISSN: 1472-6831
DOI
https://doi.org/10.1186/s12903-023-03275-6

Other articles of this Issue 1/2023

BMC Oral Health 1/2023 Go to the issue

Research

Sensitivity and specificity of the ICDAS II system and bitewing radiographs for detecting occlusal caries using the Spectra™ caries detection system as the reference test in children

Research

Pre-treatment oral microbiome analysis and salivary Stephan curve kinetics in white spot lesion development in orthodontic patients wearing fixed appliances. A pilot study

Research

Combination of metformin and double antibiotic paste for the regeneration of non-vital immature teeth: a preliminary randomized clinical study

Research article

Association between human herpes simplex virus and periodontitis: results from the continuous National Health and Nutrition Examination Survey 2009–2014

Research

Age-group-specific association of oral health and systemic health on cognitive function: a cross-sectional study of Korean elders

Research

The association between periodontal diseases and helicobacter pylori: an updated meta-analysis of observational studies