Skip to main content
Top
Published in: Graefe's Archive for Clinical and Experimental Ophthalmology 4/2017

01-04-2017 | Glaucoma

Modifiable factors in the management of glaucoma: a systematic review of current evidence

Authors: Idan Hecht, Asaf Achiron, Vitaly Man, Zvia Burgansky-Eliash

Published in: Graefe's Archive for Clinical and Experimental Ophthalmology | Issue 4/2017

Login to get access

Abstract

Purpose

Primary open angle glaucoma is a chronic optic neuropathy affecting millions of people worldwide and represents a major public health issue. Environmental factors, behaviors, and diet are intimately related to patient health and may play a role in the pathogenesis and progression of glaucoma. This study aims to review the literature, focusing on the last three years, regarding modifiable lifestyle interventions in the management of primary open angle glaucoma.

Methods

Electronic databases were searched for studies published between January 2013 and July 2016 on the topic of lifestyle interventions in primary open angle glaucoma.

Results

Sleeping with the head elevated and avoiding the worst eye-dependent side during sleep may slightly lower intraocular pressure and reduce visual field loss. Some food supplements and moderate aerobic exercise may also reduce intraocular pressure up to 2.0 and 3.0 mmHg, respectively. Frequency of coffee intake may be associated with disease progression. Potential negative effects are associated with weight-lifting and yoga exercises.

Conclusions

Certain lifestyle habits could influence glaucoma progression, yet no specific interventions are currently supported by robust evidence. Awareness of the possible influences of certain habits should help guide clinical advice and is important to help patients avoid adverse outcomes and take an active role in the management of their disease.
Literature
1.
go back to reference Heijl A, Bengtsson B, Oskarsdottir SE (2013) Prevalence and severity of undetected manifest glaucoma: results from the early manifest glaucoma trial screening. Ophthalmology 120(8):1541–1545CrossRefPubMed Heijl A, Bengtsson B, Oskarsdottir SE (2013) Prevalence and severity of undetected manifest glaucoma: results from the early manifest glaucoma trial screening. Ophthalmology 120(8):1541–1545CrossRefPubMed
2.
go back to reference Mutolo MG, Albanese G, Rusciano D, Pescosolido N (2016) Oral administration of forskolin, homotaurine, carnosine, and folic acid in patients with primary open angle glaucoma: changes in intraocular pressure, pattern electroretinogram amplitude, and foveal sensitivity. J Ocul Pharmacol Ther: Off J Assoc Ocul Pharmacol Ther 32(3):178–183CrossRef Mutolo MG, Albanese G, Rusciano D, Pescosolido N (2016) Oral administration of forskolin, homotaurine, carnosine, and folic acid in patients with primary open angle glaucoma: changes in intraocular pressure, pattern electroretinogram amplitude, and foveal sensitivity. J Ocul Pharmacol Ther: Off J Assoc Ocul Pharmacol Ther 32(3):178–183CrossRef
3.
go back to reference Lazzaro EC, Mallick A, Singh M, Reich I, Elmann S, Stefanov DG et al (2014) The effect of positional changes on intraocular pressure during sleep in patients with and without glaucoma. J Glaucoma 23(5):282–287CrossRefPubMed Lazzaro EC, Mallick A, Singh M, Reich I, Elmann S, Stefanov DG et al (2014) The effect of positional changes on intraocular pressure during sleep in patients with and without glaucoma. J Glaucoma 23(5):282–287CrossRefPubMed
4.
go back to reference Hamilton-Maxwell KE, Feeney L (2012) Walking for a short distance at a brisk pace reduces intraocular pressure by a clinically significant amount. J Glaucoma 21(6):421–425CrossRefPubMed Hamilton-Maxwell KE, Feeney L (2012) Walking for a short distance at a brisk pace reduces intraocular pressure by a clinically significant amount. J Glaucoma 21(6):421–425CrossRefPubMed
5.
go back to reference Baskaran M, Raman K, Ramani KK, Roy J, Vijaya L, Badrinath SS (2006) Intraocular pressure changes and ocular biometry during Sirsasana (headstand posture) in yoga practitioners. Ophthalmology 113(8):1327–1332CrossRefPubMed Baskaran M, Raman K, Ramani KK, Roy J, Vijaya L, Badrinath SS (2006) Intraocular pressure changes and ocular biometry during Sirsasana (headstand posture) in yoga practitioners. Ophthalmology 113(8):1327–1332CrossRefPubMed
6.
go back to reference Wan MJ, Daniel S, Kassam F, Mutti G, Butty Z, Kasner O et al (2012) Survey of complementary and alternative medicine use in glaucoma patients. J Glaucoma 21(2):79–82PubMed Wan MJ, Daniel S, Kassam F, Mutti G, Butty Z, Kasner O et al (2012) Survey of complementary and alternative medicine use in glaucoma patients. J Glaucoma 21(2):79–82PubMed
7.
go back to reference Welte AK, Hahn U, Bussing A, Krummenauer F (2016) Systematic review of the application of complementary and alternative medicine and their potential therapeutic benefits in the treatment of ophthalmology patients. Klin Monatsbl Augenheilkd. doi:10.1055/s-0042-106901 PubMed Welte AK, Hahn U, Bussing A, Krummenauer F (2016) Systematic review of the application of complementary and alternative medicine and their potential therapeutic benefits in the treatment of ophthalmology patients. Klin Monatsbl Augenheilkd. doi:10.​1055/​s-0042-106901 PubMed
11.
go back to reference Liberati A, Altman DG, Tetzlaff J, Mulrow C, Gotzsche PC, Ioannidis JP et al (2009) The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate healthcare interventions: explanation and elaboration. BMJ 339:b2700CrossRefPubMedPubMedCentral Liberati A, Altman DG, Tetzlaff J, Mulrow C, Gotzsche PC, Ioannidis JP et al (2009) The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate healthcare interventions: explanation and elaboration. BMJ 339:b2700CrossRefPubMedPubMedCentral
12.
go back to reference Keaney M, Lorimer AR (1999) Auditing the implementation of SIGN (Scottish Intercollegiate Guidelines Network) clinical guidelines. Int J Health Care Qual Assur Inc Leadersh Health Serv 12(6-7):314–317CrossRefPubMed Keaney M, Lorimer AR (1999) Auditing the implementation of SIGN (Scottish Intercollegiate Guidelines Network) clinical guidelines. Int J Health Care Qual Assur Inc Leadersh Health Serv 12(6-7):314–317CrossRefPubMed
13.
go back to reference Giaconi JA, Yu F, Stone KL, Pedula KL, Ensrud KE, Cauley JA et al (2012) The association of consumption of fruits/vegetables with decreased risk of glaucoma among older African-American women in the study of osteoporotic fractures. Am J Ophthalmol 154(4):635–644CrossRefPubMedPubMedCentral Giaconi JA, Yu F, Stone KL, Pedula KL, Ensrud KE, Cauley JA et al (2012) The association of consumption of fruits/vegetables with decreased risk of glaucoma among older African-American women in the study of osteoporotic fractures. Am J Ophthalmol 154(4):635–644CrossRefPubMedPubMedCentral
14.
go back to reference Coleman AL, Stone KL, Kodjebacheva G, Yu F, Pedula KL, Ensrud KE et al (2008) Glaucoma risk and the consumption of fruits and vegetables among older women in the study of osteoporotic fractures. Am J Ophthalmol 145(6):1081–1089CrossRefPubMed Coleman AL, Stone KL, Kodjebacheva G, Yu F, Pedula KL, Ensrud KE et al (2008) Glaucoma risk and the consumption of fruits and vegetables among older women in the study of osteoporotic fractures. Am J Ophthalmol 145(6):1081–1089CrossRefPubMed
15.
go back to reference Kang JH, Willett WC, Rosner BA, Buys E, Wiggs JL, Pasquale LR (2016) Association of dietary nitrate intake with primary open-angle glaucoma: a prospective analysis from the nurses’ health study and health professionals follow-up study. JAMA Ophthalmol 134(3):294–303CrossRefPubMedPubMedCentral Kang JH, Willett WC, Rosner BA, Buys E, Wiggs JL, Pasquale LR (2016) Association of dietary nitrate intake with primary open-angle glaucoma: a prospective analysis from the nurses’ health study and health professionals follow-up study. JAMA Ophthalmol 134(3):294–303CrossRefPubMedPubMedCentral
16.
go back to reference Wang SY, Singh K, Lin SC (2012) The association between glaucoma prevalence and supplementation with the oxidants calcium and iron. Invest Ophthalmol Vis Sci 53(2):725–731CrossRefPubMedPubMedCentral Wang SY, Singh K, Lin SC (2012) The association between glaucoma prevalence and supplementation with the oxidants calcium and iron. Invest Ophthalmol Vis Sci 53(2):725–731CrossRefPubMedPubMedCentral
17.
go back to reference Garcia-Medina JJ, Garcia-Medina M, Garrido-Fernandez P, Galvan-Espinosa J, Garcia-Maturana C, Zanon-Moreno V et al (2015) A two-year follow-up of oral antioxidant supplementation in primary open-angle glaucoma: an open-label, randomized, controlled trial. Acta Ophthalmol 93(6):546–554CrossRefPubMed Garcia-Medina JJ, Garcia-Medina M, Garrido-Fernandez P, Galvan-Espinosa J, Garcia-Maturana C, Zanon-Moreno V et al (2015) A two-year follow-up of oral antioxidant supplementation in primary open-angle glaucoma: an open-label, randomized, controlled trial. Acta Ophthalmol 93(6):546–554CrossRefPubMed
18.
go back to reference Jabbarpoor Bonyadi MH, Yazdani S, Saadat S (2014) The ocular hypotensive effect of saffron extract in primary open angle glaucoma: a pilot study. BMC Complement Altern Med 14:399CrossRefPubMedPubMedCentral Jabbarpoor Bonyadi MH, Yazdani S, Saadat S (2014) The ocular hypotensive effect of saffron extract in primary open angle glaucoma: a pilot study. BMC Complement Altern Med 14:399CrossRefPubMedPubMedCentral
19.
go back to reference Prata TS, De Moraes CG, Kanadani FN, Ritch R, Paranhos A Jr (2010) Posture-induced intraocular pressure changes: considerations regarding body position in glaucoma patients. Surv Ophthalmol 55(5):445–453CrossRefPubMed Prata TS, De Moraes CG, Kanadani FN, Ritch R, Paranhos A Jr (2010) Posture-induced intraocular pressure changes: considerations regarding body position in glaucoma patients. Surv Ophthalmol 55(5):445–453CrossRefPubMed
20.
go back to reference Buys YM, Alasbali T, Jin YP, Smith M, Gouws P, Geffen N et al (2010) Effect of sleeping in a head-up position on intraocular pressure in patients with glaucoma. Ophthalmology 117(7):1348–1351CrossRefPubMed Buys YM, Alasbali T, Jin YP, Smith M, Gouws P, Geffen N et al (2010) Effect of sleeping in a head-up position on intraocular pressure in patients with glaucoma. Ophthalmology 117(7):1348–1351CrossRefPubMed
21.
go back to reference Kim KN, Jeoung JW, Park KH, Kim DM, Ritch R (2014) Relationship between preferred sleeping position and asymmetric visual field loss in open-angle glaucoma patients. Am J Ophthalmol 157(3):739–745CrossRefPubMed Kim KN, Jeoung JW, Park KH, Kim DM, Ritch R (2014) Relationship between preferred sleeping position and asymmetric visual field loss in open-angle glaucoma patients. Am J Ophthalmol 157(3):739–745CrossRefPubMed
22.
go back to reference Lee TE, Yoo C, Lin SC, Kim YY (2015) Effect of different head positions in lateral decubitus posture on intraocular pressure in treated patients with open-angle glaucoma. Am J Ophthalmol 160(5):929–36 e4CrossRefPubMed Lee TE, Yoo C, Lin SC, Kim YY (2015) Effect of different head positions in lateral decubitus posture on intraocular pressure in treated patients with open-angle glaucoma. Am J Ophthalmol 160(5):929–36 e4CrossRefPubMed
23.
go back to reference Kaplowitz K, Blizzard S, Blizzard DJ, Nwogu E, Hamill CE, Weinreb RN et al (2015) Time spent in lateral sleep position and asymmetry in glaucoma. Invest Ophthalmol Vis Sci 56(6):3869–3874CrossRefPubMed Kaplowitz K, Blizzard S, Blizzard DJ, Nwogu E, Hamill CE, Weinreb RN et al (2015) Time spent in lateral sleep position and asymmetry in glaucoma. Invest Ophthalmol Vis Sci 56(6):3869–3874CrossRefPubMed
24.
go back to reference Flatau A, Solano F, Idrees S, Jefferys JL, Volpe P, Damion C et al (2016) Measured changes in limbal strain during simulated sleep in face down position using an instrumented contact lens in healthy adults and adults with glaucoma. JAMA Ophthalmol 134(4):375–382CrossRefPubMed Flatau A, Solano F, Idrees S, Jefferys JL, Volpe P, Damion C et al (2016) Measured changes in limbal strain during simulated sleep in face down position using an instrumented contact lens in healthy adults and adults with glaucoma. JAMA Ophthalmol 134(4):375–382CrossRefPubMed
26.
go back to reference Avisar R, Avisar E, Weinberger D (2002) Effect of coffee consumption on intraocular pressure. Ann Pharmacother 36(6):992–995CrossRefPubMed Avisar R, Avisar E, Weinberger D (2002) Effect of coffee consumption on intraocular pressure. Ann Pharmacother 36(6):992–995CrossRefPubMed
27.
go back to reference Okimi PH, Sportsman S, Pickard MR, Fritsche MB (1991) Effects of caffeinated coffee on intraocular pressure. Appl Nurs Res: ANR 4(2):72–76CrossRefPubMed Okimi PH, Sportsman S, Pickard MR, Fritsche MB (1991) Effects of caffeinated coffee on intraocular pressure. Appl Nurs Res: ANR 4(2):72–76CrossRefPubMed
28.
go back to reference Jiwani AZ, Rhee DJ, Brauner SC, Gardiner MF, Chen TC, Shen LQ et al (2012) Effects of caffeinated coffee consumption on intraocular pressure, ocular perfusion pressure, and ocular pulse amplitude: a randomized controlled trial. Eye 26(8):1122–1130CrossRefPubMedPubMedCentral Jiwani AZ, Rhee DJ, Brauner SC, Gardiner MF, Chen TC, Shen LQ et al (2012) Effects of caffeinated coffee consumption on intraocular pressure, ocular perfusion pressure, and ocular pulse amplitude: a randomized controlled trial. Eye 26(8):1122–1130CrossRefPubMedPubMedCentral
29.
go back to reference Li M, Wang M, Guo W, Wang J, Sun X (2011) The effect of caffeine on intraocular pressure: a systematic review and meta-analysis. Graefes Arch Clin Exp Ophthalmol = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie 249(3):435–442CrossRefPubMed Li M, Wang M, Guo W, Wang J, Sun X (2011) The effect of caffeine on intraocular pressure: a systematic review and meta-analysis. Graefes Arch Clin Exp Ophthalmol = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie 249(3):435–442CrossRefPubMed
30.
go back to reference Kang JH, Willett WC, Rosner BA, Hankinson SE, Pasquale LR (2008) Caffeine consumption and the risk of primary open-angle glaucoma: a prospective cohort study. Invest Ophthalmol Vis Sci 49(5):1924–1931CrossRefPubMedPubMedCentral Kang JH, Willett WC, Rosner BA, Hankinson SE, Pasquale LR (2008) Caffeine consumption and the risk of primary open-angle glaucoma: a prospective cohort study. Invest Ophthalmol Vis Sci 49(5):1924–1931CrossRefPubMedPubMedCentral
31.
go back to reference Kang JH, Loomis SJ, Rosner BA, Wiggs JL, Pasquale LR (2015) Comparison of risk factor profiles for primary open-angle glaucoma subtypes defined by pattern of visual field loss: a prospective study. Invest Ophthalmol Vis Sci 56(4):2439–2448CrossRefPubMedPubMedCentral Kang JH, Loomis SJ, Rosner BA, Wiggs JL, Pasquale LR (2015) Comparison of risk factor profiles for primary open-angle glaucoma subtypes defined by pattern of visual field loss: a prospective study. Invest Ophthalmol Vis Sci 56(4):2439–2448CrossRefPubMedPubMedCentral
32.
go back to reference Aziz NAA, Ali ANA, Kamarudin MN, Shaari NA, Hitam WHW, Yaakub A et al (2015) Coffee intake and progression of glaucoma. Int J Clin Nutr 3(1):7–11 Aziz NAA, Ali ANA, Kamarudin MN, Shaari NA, Hitam WHW, Yaakub A et al (2015) Coffee intake and progression of glaucoma. Int J Clin Nutr 3(1):7–11
33.
go back to reference Liang YB, Wu Y, Li SZ, Sun LP, Wang NL (2011) Physical exercise and intraocular pressure. Zhonghua Yan Ke Za Zhi (Chin J Opthalmol) 47(9):854–857 Liang YB, Wu Y, Li SZ, Sun LP, Wang NL (2011) Physical exercise and intraocular pressure. Zhonghua Yan Ke Za Zhi (Chin J Opthalmol) 47(9):854–857
34.
go back to reference Vieira GM, Oliveira HB, de Andrade DT, Bottaro M, Ritch R (2006) Intraocular pressure variation during weight lifting. Arch Ophthalmol 124(9):1251–1254CrossRefPubMed Vieira GM, Oliveira HB, de Andrade DT, Bottaro M, Ritch R (2006) Intraocular pressure variation during weight lifting. Arch Ophthalmol 124(9):1251–1254CrossRefPubMed
35.
go back to reference Risner D, Ehrlich R, Kheradiya NS, Siesky B, McCranor L, Harris A (2009) Effects of exercise on intraocular pressure and ocular blood flow: a review. J Glaucoma 18(6):429–436CrossRefPubMed Risner D, Ehrlich R, Kheradiya NS, Siesky B, McCranor L, Harris A (2009) Effects of exercise on intraocular pressure and ocular blood flow: a review. J Glaucoma 18(6):429–436CrossRefPubMed
37.
go back to reference Agrawal A (2015) A prospective study to compare safety and efficacy of various anti-glaucoma agents and evaluate the effect of aerobic exercise on intra-ocular pressure in newly diagnosed primary open angle glaucoma patients in a tertiary care hospital. Value Health: J Int Soc Pharmacoeconomics Outcome Res 18(7):A415CrossRef Agrawal A (2015) A prospective study to compare safety and efficacy of various anti-glaucoma agents and evaluate the effect of aerobic exercise on intra-ocular pressure in newly diagnosed primary open angle glaucoma patients in a tertiary care hospital. Value Health: J Int Soc Pharmacoeconomics Outcome Res 18(7):A415CrossRef
38.
go back to reference Cramer H, Krucoff C, Dobos G (2013) Adverse events associated with yoga: a systematic review of published case reports and case series. PLoS One 8(10):e75515CrossRefPubMedPubMedCentral Cramer H, Krucoff C, Dobos G (2013) Adverse events associated with yoga: a systematic review of published case reports and case series. PLoS One 8(10):e75515CrossRefPubMedPubMedCentral
39.
go back to reference Jasien JV, Jonas JB, de Moraes CG, Ritch R (2015) Intraocular pressure rise in subjects with and without glaucoma during four common yoga positions. PLoS One 10(12):e0144505CrossRefPubMedPubMedCentral Jasien JV, Jonas JB, de Moraes CG, Ritch R (2015) Intraocular pressure rise in subjects with and without glaucoma during four common yoga positions. PLoS One 10(12):e0144505CrossRefPubMedPubMedCentral
40.
go back to reference Ma KT, Chung WS, Seo KY, Seong GJ, Kim CY (2007) The effect of swimming goggles on intraocular pressure and blood flow within the optic nerve head. Yonsei Med J 48(5):807–809CrossRefPubMedPubMedCentral Ma KT, Chung WS, Seo KY, Seong GJ, Kim CY (2007) The effect of swimming goggles on intraocular pressure and blood flow within the optic nerve head. Yonsei Med J 48(5):807–809CrossRefPubMedPubMedCentral
41.
go back to reference Morgan WH, Cunneen TS, Balaratnasingam C, Yu DY (2008) Wearing swimming goggles can elevate intraocular pressure. Br J Ophthalmol 92(9):1218–1221CrossRefPubMed Morgan WH, Cunneen TS, Balaratnasingam C, Yu DY (2008) Wearing swimming goggles can elevate intraocular pressure. Br J Ophthalmol 92(9):1218–1221CrossRefPubMed
42.
go back to reference Starr CE, Radcliffe NM (2009) Swimming goggles and elevated intraocular pressure. Br J Ophthalmol 93(5):700CrossRefPubMed Starr CE, Radcliffe NM (2009) Swimming goggles and elevated intraocular pressure. Br J Ophthalmol 93(5):700CrossRefPubMed
44.
go back to reference Franchina M, Yazar S, Booth L, Wan SL, Cox K, Kang MH et al (2015) Swimming goggle wear is not associated with an increased prevalence of glaucoma. Br J Ophthalmol 99(2):255–257CrossRefPubMed Franchina M, Yazar S, Booth L, Wan SL, Cox K, Kang MH et al (2015) Swimming goggle wear is not associated with an increased prevalence of glaucoma. Br J Ophthalmol 99(2):255–257CrossRefPubMed
45.
go back to reference Talty P, O’Brien PD (2005) Does extended wear of a tight necktie cause raised intraocular pressure? J Glaucoma 14(6):508–510CrossRefPubMed Talty P, O’Brien PD (2005) Does extended wear of a tight necktie cause raised intraocular pressure? J Glaucoma 14(6):508–510CrossRefPubMed
46.
go back to reference Kang JH, Willett WC, Rosner BA, Hankinson SE, Pasquale LR (2007) Prospective study of alcohol consumption and the risk of primary open-angle glaucoma. Ophthalmic Epidemiol 14(3):141–147CrossRefPubMed Kang JH, Willett WC, Rosner BA, Hankinson SE, Pasquale LR (2007) Prospective study of alcohol consumption and the risk of primary open-angle glaucoma. Ophthalmic Epidemiol 14(3):141–147CrossRefPubMed
48.
go back to reference Jain V, Jain M, Abdull MM, Bastawrous A (2016) The association between cigarette smoking and primary open-angle glaucoma: a systematic review. Int Ophthalmol. doi:10.1007/s10792-016-0245-0 Jain V, Jain M, Abdull MM, Bastawrous A (2016) The association between cigarette smoking and primary open-angle glaucoma: a systematic review. Int Ophthalmol. doi:10.​1007/​s10792-016-0245-0
49.
go back to reference Joy JE, Watson SJ Jr, Benson JA Jr (1999) Marijuana and medicine: assessing the science base. National Academies Press (US), Washington (DC) Joy JE, Watson SJ Jr, Benson JA Jr (1999) Marijuana and medicine: assessing the science base. National Academies Press (US), Washington (DC)
50.
go back to reference Heijl A, Leske MC, Bengtsson B, Hyman L, Bengtsson B, Hussein M et al (2002) Reduction of intraocular pressure and glaucoma progression: results from the Early Manifest Glaucoma Trial. Arch Ophthalmol 120(10):1268–1279CrossRefPubMed Heijl A, Leske MC, Bengtsson B, Hyman L, Bengtsson B, Hussein M et al (2002) Reduction of intraocular pressure and glaucoma progression: results from the Early Manifest Glaucoma Trial. Arch Ophthalmol 120(10):1268–1279CrossRefPubMed
51.
go back to reference Drance SM (1963) Diurnal variation of intraocular pressure in treated glaucoma. Significance in patients with chronic simple glaucoma. Arch Ophthalmol 70:302–311CrossRefPubMed Drance SM (1963) Diurnal variation of intraocular pressure in treated glaucoma. Significance in patients with chronic simple glaucoma. Arch Ophthalmol 70:302–311CrossRefPubMed
52.
go back to reference Agnifili L, Mastropasqua R, Frezzotti P, Fasanella V, Motolese I, Pedrotti E et al (2015) Circadian intraocular pressure patterns in healthy subjects, primary open angle and normal tension glaucoma patients with a contact lens sensor. Acta Ophthalmol 93(1):e14–e21CrossRefPubMed Agnifili L, Mastropasqua R, Frezzotti P, Fasanella V, Motolese I, Pedrotti E et al (2015) Circadian intraocular pressure patterns in healthy subjects, primary open angle and normal tension glaucoma patients with a contact lens sensor. Acta Ophthalmol 93(1):e14–e21CrossRefPubMed
53.
go back to reference Age-Related Eye Disease Study Research G (2001) A randomized, placebo-controlled, clinical trial of high-dose supplementation with vitamins C and E, beta carotene, and zinc for age-related macular degeneration and vision loss: AREDS report no. 8. Arch Ophthalmol 119(10):1417–1436CrossRef Age-Related Eye Disease Study Research G (2001) A randomized, placebo-controlled, clinical trial of high-dose supplementation with vitamins C and E, beta carotene, and zinc for age-related macular degeneration and vision loss: AREDS report no. 8. Arch Ophthalmol 119(10):1417–1436CrossRef
Metadata
Title
Modifiable factors in the management of glaucoma: a systematic review of current evidence
Authors
Idan Hecht
Asaf Achiron
Vitaly Man
Zvia Burgansky-Eliash
Publication date
01-04-2017
Publisher
Springer Berlin Heidelberg
Published in
Graefe's Archive for Clinical and Experimental Ophthalmology / Issue 4/2017
Print ISSN: 0721-832X
Electronic ISSN: 1435-702X
DOI
https://doi.org/10.1007/s00417-016-3518-4

Other articles of this Issue 4/2017

Graefe's Archive for Clinical and Experimental Ophthalmology 4/2017 Go to the issue

Acknowledgement to referees

Thank you list 2016