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Journal of Cardiothoracic Surgery

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Open Access 01-12-2021 | Mitral Valve Replacement | Review

Outcome of mitral valve repair or replacement for non-ischemic mitral regurgitation: a systematic review and meta-analysis

Authors: Qianqian Fan, Xiaoguang Li, Guilan Cao, Puliang Yu, Fengxiao Zhang

Published in: Journal of Cardiothoracic Surgery | Issue 1/2021

Abstract

Background

Mitral regurgitation (MR) is a rather common valvular heart disease. The aim of this systematic review and meta-analysis was to compare the outcomes, and complications of mitral valve (MV) replacement with surgical MV repair of non-ischemic MR (NIMR)

Methods

MEDLINE, EMBASE, and the Cochrane Central Register of Controlled Trials were searched until October, 2020. Studies were eligible for inclusion if they included patients with MR and reported early (30-day or in-hospital) or late all-cause mortality. For each study, data on all-cause mortality and incidence of reoperation and operative complications in both groups were used to generate odds ratios (ORs) or hazard ratios (HRs). This study is registered with PROSPERO, CRD42018089608.

Results

The literature search yielded 4834 studies, of which 20 studies, including a total of 21,898 patients with NIMR, were included. The pooled analysis showed that lower age, less female inclusion and incident of hypertension, significantly higher rates of diabetes and atrial fibrillation in the MV replacement group than MV repair group. No significant differences in the rates of pre-operative left ventricle ejection fraction (LVEF) and heart failure were observed between groups. The number of patients in the MV repair group was lower than in the MV replacement group. We found that there were significantly increased risks of mortality associated with replacement of MR. Moreover, the rate of re-operation and post-operative MR in the MV repair group was lower than in the MV replacement group.

Conclusions

In patients with NIMR, MV repair achieves higher survival and leads to fewer complications than surgical MV replacement. In light of these results, we suggest that MV repair surgery should be a priority for NIMR patients.

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Title: Outcome of mitral valve repair or replacement for non-ischemic mitral regurgitation: a systematic review and meta-analysis
Authors: Qianqian Fan
Xiaoguang Li
Guilan Cao
Puliang Yu
Fengxiao Zhang
Publication date: 01-12-2021
Publisher: BioMed Central
Keywords: Mitral Valve Replacement
Atrial Fibrillation
Mitral Valve Replacement
Mitral Valve Replacement
Published in: Journal of Cardiothoracic Surgery / Issue 1/2021
Electronic ISSN: 1749-8090
DOI: https://doi.org/10.1186/s13019-021-01563-2

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Outcome of mitral valve repair or replacement for non-ischemic mitral regurgitation: a systematic review and meta-analysis

Abstract

Background

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Methods

Results

Conclusions

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