Published in:
01-06-2007 | Poster presentation
Mitochondrial injury in sepsis
Authors:
AC Nogueira, W Hoshino, L Gonzaga, V Reze, A Duarte, C Valeri, P Branquinho, M Seckler, E Estumano, V Kawabata, D Noritomi, S Cappi, M Lins, M Miranda, K Sichieri, F Maia, AS Colombo, EL Azevedo, BCS Martins, M Bernik, EG Caldini, PA Lotufo, FG Soriano
Published in:
Critical Care
|
Special Issue 3/2007
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Excerpt
Sepsis-induced multiple organ failure is the major cause of mortality and morbidity in critically ill patients. However, the precise mechanisms by which this dysfunction is caused remain to be elucidated. It seems that, in sepsis, mitochondria dysfunction results in raised tissue oxygen tensions and organ failure. Possibly due to oxide nitric, that is produced in excess in sepsis, and is known to inhibit mitochondrial respiration in vitro. …
