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Indian Journal of Hematology and Blood Transfusion
Published in: Indian Journal of Hematology and Blood Transfusion 1/2016

01-06-2016 | Case Report

Misdiagnosis of Bone Metastasis Cancer After Using Adefovir Dipivoxi in a Hepatitis B Patient with Fanconi Syndrome

Authors: Xin Li, Man Shen, Wan-jun Sun, Zhong-xia Huang, Na An, Jia-jia Zhang

Published in: Indian Journal of Hematology and Blood Transfusion | Special Issue 1/2016

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Abstract

Adefovir dipivoxil is commonly used for treatment of chronic hepatitis B patients. We present a case of acquired Fanconi syndrome and hypophosphatemic osteomalacia in a patient with chronic hepatitis B who had been treated with ADV for 8 years. A 41-year-old man complained of severe bilateral hypochondrium pain and lower limb weakness, and he had the diagnosis of bone metastasis cancer or multiple myeloma. Laboratory results and radiologic findings suggested Fanconi syndrome with osteomalacia after hospitalized. For it is difficult to accurately diagnose in clinic and prone to misdiagnose, more attention should be paid to the kidney damage in the patients treated with long-term ADV.
Literature
1.
Jung YK, Yeon JE, Choi JH, Kim CH, Jung ES, Kim JH, Park JJ, Kim JS, Bak YT, Byun KS (2010) Fanconi’s syndrome associated with prolonged adefovir dipivoxil therapy in a Hepatitis B virus patient. Gut Liver 4(3):389–393CrossRefPubMedPubMedCentral
2.
Tamori A, Enomoto M, Kobayashi S (2010) Add-on combination therapy with adefovir dipivoxil induces renal impairment in patients with lamivudine-refractory hepatitis B virus. Viral Hepat J 17(2):123–129CrossRef
3.
Law ST, Li KK, Ho YY (2011) Acquired Fanconi syndrome associated with prolonged adefovir dipivoxil therapy in a chronic hepatitis B patient. Am J Ther 20(6):713–716CrossRef
4.
Earle KE, Seneviratne T, Shaker J, Shoback D (2004) Fanconi’s syndrome in HIV+adults: report of three cases and literature review. J Bone Miner Res 19:714–721CrossRefPubMed
5.
Laing CM, Toye AM, Capasso G, Unwin RJ (2005) Renal tubular acidosis: developments in our understanding of the molecular basis. Int J Biochem Cell Biol 37:1151–1161CrossRefPubMed
6.
Lino M, Binaut R, Noel LH, Patey N, Rustin P, Daniel L, Serpaggi J, Varaut A, Vanhille P, Knebelmann B, Grünfeld JP, Fakhouri F (2005) Tubulointerstitial nephritis and Fanconi syndrome in primary biliary cirrhosis. Am J Kidney Dis 46(3):e41–e46CrossRefPubMed
7.
Girgis CM, Wong T, Ngu MC, Emmett L, Archer KA, Chen RC, Seibel MJ (2011) Hypophosphataemic osteomalacia in patients on adefovir dipivoxil. J Clin Gastroenterol 45(5):468–473CrossRefPubMed
8.
Kwon SY, Ahn SY, Ko SY, Jang YM, Choi YH, Kim BK, Choe WH, Lee CH (2010) A case of osteomalacia related to adefovir in a patient with chronic hepatitis B. Korean J Gastroenterol 56(2):117–120CrossRefPubMed
9.
Lee HJ, Choi JW, Kim TN, Eun JR (2008) A case of severe hypophosphatemia related to adefovir dipivoxil treatment in a patient with liver cirrhosis related to hepatitis B virus. Korean J Hepatol 14(3):381–386CrossRefPubMed
10.
Nakanishi K, Sakai M, Tanaka H, Tsuboi H, Hashimoto J, Hashimoto N, Tomiyama N (2013) Whole-body MR imaging in detecting phosphaturic mesenchymal tumor (PMT) in tumor-induced hypophosphatemic osteomalacia. Magn Reson Med Sci 12:47–52CrossRefPubMed
11.
Kahn J, Lagakos S, Wulfsohn M, Cherng D, Miller M, Cherrington J, Hardy D, Beall G, Cooper R, Murphy R, Basgoz N, Ng E, Deeks S, Winslow D, Toole JJ, Coakley D (1999) Efficacy and safety of adefovir dipivoxil with antiretroviral therapy: a randomized controlled trial. JAMA 82:2305–2312CrossRef
Metadata
Title
Misdiagnosis of Bone Metastasis Cancer After Using Adefovir Dipivoxi in a Hepatitis B Patient with Fanconi Syndrome
Authors
Xin Li
Man Shen
Wan-jun Sun
Zhong-xia Huang
Na An
Jia-jia Zhang
Publication date
01-06-2016
Publisher
Springer India
Published in
Indian Journal of Hematology and Blood Transfusion / Issue Special Issue 1/2016
Print ISSN: 0971-4502
Electronic ISSN: 0974-0449
DOI
https://doi.org/10.1007/s12288-015-0501-x

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