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01-09-2019 | Miscarriage | Gynecologic Endocrinology and Reproductive Medicine

Hereditary thrombophilia genetic variants in recurrent pregnancy loss

Authors: Najmeh Ahangari, Mohammad Doosti, Nezhat Mousavifar, Matin Attaran, Sima Shahrokhzadeh, Sara Memarpour, Ehsan Ghayoor Karimiani

Published in: Archives of Gynecology and Obstetrics | Issue 3/2019

Abstract

Background

The relationship between thrombophilia genes and recurrent pregnancy loss has been discussed. The aim of this study was to investigate the association between of MTHFR C677T, A1298C, F2G20210A, and F5 G1691A genetic variants among Iranian women with recurrent miscarriage.

Methods

A total of 245 women with two or more recurrent pregnancy loss, with mean age years were enrolled in the study. To compare genotypes, we have selected 250 healthy women without history of miscarriage as control group. Genomic DNA of participants was evaluated using polymerase chain reaction followed by Sanger sequencing to determine the genotype frequency.

Results

The mean age were 32.16 ± (21–42) and 31.81 ± (19–40) for case and control groups respectively. MTHFR C677T and A1298C mutant alleles were found to be significantly more prevalent in patients than control. However, F2G20210A and F5 G1691A genetic variants showed no significance.

Conclusion

The allele frequencies for the assessed genotypes in this study are consistent with the data obtained for other countries. We observed significant susceptible effects of MTHFR C677T, and A1298C among participants. According to the relatively high prevalence of these variants, we recommend genetic testing for women with RPL before therapeutic decisions.

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Title: Hereditary thrombophilia genetic variants in recurrent pregnancy loss
Authors: Najmeh Ahangari
Mohammad Doosti
Nezhat Mousavifar
Matin Attaran
Sima Shahrokhzadeh
Sara Memarpour
Ehsan Ghayoor Karimiani
Publication date: 01-09-2019
Publisher: Springer Berlin Heidelberg
Keyword: Miscarriage
Published in: Archives of Gynecology and Obstetrics / Issue 3/2019
Print ISSN: 0932-0067
Electronic ISSN: 1432-0711
DOI: https://doi.org/10.1007/s00404-019-05224-7

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Hereditary thrombophilia genetic variants in recurrent pregnancy loss

Abstract

Background

Methods

Results

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Methods

Results

Conclusion

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