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Medical Molecular Morphology
Published in: Medical Molecular Morphology 2/2017

01-06-2017 | Original Paper

miR-106a suppresses tumor cells death in colorectal cancer through targeting ATG7

Authors: Haibin Hao, Guangfeng Xia, Chao Wang, Fuping Zhong, Laipeng Liu, Dong Zhang

Published in: Medical Molecular Morphology | Issue 2/2017

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Abstract

Autophagy-related gene 7 (ATG7) and miR-106a play an important role in cancer cell autophagy and apoptosis, but the outcome of ATG7 and miR-106a in colorectal cancer (CRC) still remains not clear. In this study, we found that ATG7 and miR-106a expression were mutually related with cell death and prognosis in CRC patients. In addition, we also showed that ATG7 and miR-106a expression were changeable in colorectal cancer cell lines when compared with normal cell lines, but ATG7 and miR-106a mRNA level was negatively correlated. Furthermore, ATG7 protein and mRNA levels decreased after over-expression of miR-106a, whereas the suppression of ATG7 had the opposite effect. We confirmed that miR-106a down-regulated ATG7 mRNA level by binding the specific sequence of ATG7 mRNA 3′UTR region. Moreover, the over-expression of ATG7 induced CRC cells death both in vitro and in vivo. Taken together, our study data demonstrated that ATG7 aggravated the cell death of CRC, which was inhibited by miR-106a.
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Metadata
Title
miR-106a suppresses tumor cells death in colorectal cancer through targeting ATG7
Authors
Haibin Hao
Guangfeng Xia
Chao Wang
Fuping Zhong
Laipeng Liu
Dong Zhang
Publication date
01-06-2017
Publisher
Springer Japan
Published in
Medical Molecular Morphology / Issue 2/2017
Print ISSN: 1860-1480
Electronic ISSN: 1860-1499
DOI
https://doi.org/10.1007/s00795-016-0150-7

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