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Published in: Neurological Sciences 7/2014

01-07-2014 | Original Article

Minocycline improves peripheral and autonomic neuropathy in type 2 diabetes: MIND study

Authors: Ashit Syngle, Inderjeet Verma, Pawan Krishan, Nidhi Garg, Vijaita Syngle

Published in: Neurological Sciences | Issue 7/2014

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Abstract

Diabetic peripheral neuropathy and diabetic autonomic neuropathy are serious and common complications of diabetes associated with increased risk of mortality and cardiovascular disease. We sought to evaluate the safety and efficacy of minocycline in type 2 diabetic patients with diabetic peripheral and autonomic neuropathy. In a randomized placebo controlled study, 50 outpatients were randomly assigned to receive 100 mg minocycline or placebo. Outcome measures included the vibration perception threshold (VPT), Leeds assessment of neuropathic symptoms and signs (LANSS), Pain Disability Index (PDI), Visual Analog Scale (VAS), beck depression inventory (BDI), health assessment questionnaire (HAQ) and autonomic neuropathy, assessed by cardiovascular reflex tests according to Ewing and peripheral sympathetic autonomic function was assessed by FDA approved Sudoscan. At baseline there were no significant differences between demographic variables and the neuropathy variables in the minocycline and placebo groups. After treatment, VPT significantly improved in the minocycline group as compared to the placebo group. Mean posttreatment scores on the LANSS, PDI and HAQ were significantly lower in the minocycline group compared with the placebo group. However, BDI and VAS significantly (p = 0.01) improved in both minocycline and placebo groups (Table 2). After treatment with minocycline, heart rate (HR) response to standing significantly improved, while there was a borderline significance toward a reduction in HR response to deep breath. These finding indicate that 6-week oral treatment with minocycline is safe, well tolerated and significantly improves peripheral and autonomic neuropathy in type 2 diabetic patients.
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Metadata
Title
Minocycline improves peripheral and autonomic neuropathy in type 2 diabetes: MIND study
Authors
Ashit Syngle
Inderjeet Verma
Pawan Krishan
Nidhi Garg
Vijaita Syngle
Publication date
01-07-2014
Publisher
Springer Milan
Published in
Neurological Sciences / Issue 7/2014
Print ISSN: 1590-1874
Electronic ISSN: 1590-3478
DOI
https://doi.org/10.1007/s10072-014-1647-2

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