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Published in: Current Anesthesiology Reports 3/2016

01-09-2016 | Neuroanesthesia (M Smith, Section Editor)

Minimizing Complications in Major Spine Surgery: The Role of the Anesthesiologist

Authors: Koffi M. Kla, Lorri A. Lee

Published in: Current Anesthesiology Reports | Issue 3/2016

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Abstract

Purpose of review

The complexity of spine surgery has increased dramatically over the last two decades. This review highlights the impact the anesthesiologist can have on minimizing complications in these challenging procedures, often performed on patients with multiple comorbidities.

Recent findings

Recent findings include the increased use of antifibrinolytics for major spine surgery to decrease blood loss; prehabilitation to improve patients’ fitness for surgery and speed recovery; and the use of more multimodal nonopioid analgesics so that patients suffer fewer opioid-related side effects and decrease the potential for long-term opioid dependency. Additionally, a recent multicenter case–control study identified both potentially modifiable and nonmodifiable risk factors associated with ischemic optic neuropathy and spinal fusion surgery.

Summary

Patients undergoing major spine surgery should be treated by a multidisciplinary team throughout the perioperative period. Recent advances in pre-, intra-, and postoperative management, where the anesthesiologist plays a major role, can help minimize complications.
Literature
1.
go back to reference Li G, Patil CG, Lad SP, Ho C, Tian W, Boakye M. Effects of age and comorbidities on complication rates and adverse outcomes after lumbar laminectomy in elderly patients. Spine. 2008;33(11):1250–5.CrossRef Li G, Patil CG, Lad SP, Ho C, Tian W, Boakye M. Effects of age and comorbidities on complication rates and adverse outcomes after lumbar laminectomy in elderly patients. Spine. 2008;33(11):1250–5.CrossRef
2.
go back to reference Deyo RA, Mirza SK, Martin BI, Kreuter W, Goodman DC, Jarvik JG. Trends, major medical complications, and charges associated with surgery for lumbar spinal stenosis in older adults. JAMA. 2010;303(13):1259–65.CrossRef Deyo RA, Mirza SK, Martin BI, Kreuter W, Goodman DC, Jarvik JG. Trends, major medical complications, and charges associated with surgery for lumbar spinal stenosis in older adults. JAMA. 2010;303(13):1259–65.CrossRef
3.
go back to reference Oosterhuis T, Costa LO, Maher CG, de Vet HC, van Tulder MW, Ostelo RW. Rehabilitation after lumbar disc surgery. Cochrane Database System Rev. 2014;3:CD003007. Oosterhuis T, Costa LO, Maher CG, de Vet HC, van Tulder MW, Ostelo RW. Rehabilitation after lumbar disc surgery. Cochrane Database System Rev. 2014;3:CD003007.
4.
go back to reference McGregor AH, Probyn K, Cro S, et al. Rehabilitation following surgery for lumbar spinal stenosis. Cochrane Database System Rev. 2013;12:CD009644. McGregor AH, Probyn K, Cro S, et al. Rehabilitation following surgery for lumbar spinal stenosis. Cochrane Database System Rev. 2013;12:CD009644.
5.
go back to reference Nielsen PR, Jorgensen LD, Dahl B, Pedersen T, Tonnesen H. Prehabilitation and early rehabilitation after spinal surgery: randomized clinical trial. Clin Rehabil. 2010;24(2):137–48.CrossRef Nielsen PR, Jorgensen LD, Dahl B, Pedersen T, Tonnesen H. Prehabilitation and early rehabilitation after spinal surgery: randomized clinical trial. Clin Rehabil. 2010;24(2):137–48.CrossRef
6.
go back to reference Nielsen PR, Andreasen J, Asmussen M, Tonnesen H. Costs and quality of life for prehabilitation and early rehabilitation after surgery of the lumbar spine. BMC Health Serv Res. 2008;8:209.CrossRef Nielsen PR, Andreasen J, Asmussen M, Tonnesen H. Costs and quality of life for prehabilitation and early rehabilitation after surgery of the lumbar spine. BMC Health Serv Res. 2008;8:209.CrossRef
7.
go back to reference Manchikanti L, Helm S, Fellows B, et al. Opioid epidemic in the United States. Pain physician. 2012;15(3 Suppl):ES9.PubMed Manchikanti L, Helm S, Fellows B, et al. Opioid epidemic in the United States. Pain physician. 2012;15(3 Suppl):ES9.PubMed
8.
go back to reference •• Frenk SM, Porter KS, Paulozzi LJ. Prescription opioid analgesic use among adults: United States, 1999–2012. NCHS Data Brief. 2015; 189:1–8. This study highlights the dramatic increase prescription opioid analgesic use in the United States over the past two decades. •• Frenk SM, Porter KS, Paulozzi LJ. Prescription opioid analgesic use among adults: United States, 1999–2012. NCHS Data Brief. 2015; 189:1–8. This study highlights the dramatic increase prescription opioid analgesic use in the United States over the past two decades.
9.
go back to reference Dowell D, Haegerich TM, Chou R. CDC guideline for prescribing opioids for chronic pain-United States, 2016. JAMA. 2016;315(15):1624–45.CrossRef Dowell D, Haegerich TM, Chou R. CDC guideline for prescribing opioids for chronic pain-United States, 2016. JAMA. 2016;315(15):1624–45.CrossRef
10.
go back to reference Walid MS, Hyer L, Ajjan M, Barth AC, Robinson JS. Prevalence of opioid dependence in spine surgery patients and correlation with length of stay. J Opioid Manag. 2007;3(3):127–8.CrossRef Walid MS, Hyer L, Ajjan M, Barth AC, Robinson JS. Prevalence of opioid dependence in spine surgery patients and correlation with length of stay. J Opioid Manag. 2007;3(3):127–8.CrossRef
11.
go back to reference Chapman CR, Davis J, Donaldson GW, Naylor J, Winchester D. Postoperative pain trajectories in chronic pain patients undergoing surgery: the effects of chronic opioid pharmacotherapy on acute pain. J Pain. 2011;12(12):1240–6.CrossRef Chapman CR, Davis J, Donaldson GW, Naylor J, Winchester D. Postoperative pain trajectories in chronic pain patients undergoing surgery: the effects of chronic opioid pharmacotherapy on acute pain. J Pain. 2011;12(12):1240–6.CrossRef
12.
go back to reference Lawrence JTR, London N, Bohlman HH, Chin KR. Preoperative narcotic use as a predictor of clinical outcome—results following anterior cervical arthrodesis. Spine. 2008;33(19):2074–8.CrossRef Lawrence JTR, London N, Bohlman HH, Chin KR. Preoperative narcotic use as a predictor of clinical outcome—results following anterior cervical arthrodesis. Spine. 2008;33(19):2074–8.CrossRef
13.
go back to reference Juratli SM, Mirza SK, Fulton-Kehoe D, Wickizer TM, Franklin GM. Mortality after lumbar fusion surgery. Spine. 2009;34(7):740–7.CrossRef Juratli SM, Mirza SK, Fulton-Kehoe D, Wickizer TM, Franklin GM. Mortality after lumbar fusion surgery. Spine. 2009;34(7):740–7.CrossRef
14.
go back to reference Mokdad AH, Ford ES, Bowman BA, et al. Prevalence of obesity, diabetes, and obesity-related health risk factors, 2001. JAMA. 2003;289(1):76–9.CrossRef Mokdad AH, Ford ES, Bowman BA, et al. Prevalence of obesity, diabetes, and obesity-related health risk factors, 2001. JAMA. 2003;289(1):76–9.CrossRef
15.
go back to reference •• Porhomayon J, Leissner KB, El-Solh AA, Nader ND. Strategies in postoperative analgesia in the obese obstructive sleep apnea patient. Clin J Pain. 2013;29(11):998–1005. Review article describing the complexities of treating postoperative pain in patients with obstructive sleep apnea. Strategies and protocols to identify patients with or at risk for sleep apnea can helpful in management. Minimizing sedatives and opioids as well as the ability to monitor for postoperative respiratory events can be helpful in this high risk population. CrossRef •• Porhomayon J, Leissner KB, El-Solh AA, Nader ND. Strategies in postoperative analgesia in the obese obstructive sleep apnea patient. Clin J Pain. 2013;29(11):998–1005. Review article describing the complexities of treating postoperative pain in patients with obstructive sleep apnea. Strategies and protocols to identify patients with or at risk for sleep apnea can helpful in management. Minimizing sedatives and opioids as well as the ability to monitor for postoperative respiratory events can be helpful in this high risk population. CrossRef
16.
go back to reference Romero-Corral A, Caples SM, Lopez-Jimenez F, Somers VK. Interactions between obesity and obstructive sleep apnea implications for treatment. Chest. 2010;137(3):711–9.CrossRef Romero-Corral A, Caples SM, Lopez-Jimenez F, Somers VK. Interactions between obesity and obstructive sleep apnea implications for treatment. Chest. 2010;137(3):711–9.CrossRef
17.
go back to reference •• Mathiesen O, Dahl B, Thomsen BA, et al. A comprehensive multimodal pain treatment reduces opioid consumption after multilevel spine surgery. Eur Spine J. 2013;22(9): 2089–96. A new multimodal pain and nausea protocol was instituted for patients undergoing multilevel spine surgery. The multimodal regimen included acetaminophen, NSAIDs, gabapentin, ketamine, dexamethasone, ondansetron and epidural local anesthetic infusion or patient controlled analgesia with morphine. The multimodal pain and nausea regimen significantly reduced opioid consumption, improved mobilization postoperatively when compared to standard care with a loss side effect profile. CrossRef •• Mathiesen O, Dahl B, Thomsen BA, et al. A comprehensive multimodal pain treatment reduces opioid consumption after multilevel spine surgery. Eur Spine J. 2013;22(9): 2089–96. A new multimodal pain and nausea protocol was instituted for patients undergoing multilevel spine surgery. The multimodal regimen included acetaminophen, NSAIDs, gabapentin, ketamine, dexamethasone, ondansetron and epidural local anesthetic infusion or patient controlled analgesia with morphine. The multimodal pain and nausea regimen significantly reduced opioid consumption, improved mobilization postoperatively when compared to standard care with a loss side effect profile. CrossRef
18.
go back to reference Ortmann E, Besser MW, Klein AA. Antifibrinolytic agents in current anaesthetic practice. Br J Anaesth. 2013;111(4):549–63.CrossRef Ortmann E, Besser MW, Klein AA. Antifibrinolytic agents in current anaesthetic practice. Br J Anaesth. 2013;111(4):549–63.CrossRef
19.
go back to reference Harrigan MR, Rajneesh KF, Ardelt AA, Fisher WS. Short-term antifibrinolytic therapy before early aneurysm treatment in subarachnoid hemorrhage: effects on rehemorrhage, cerebral ischemia, and hydrocephalus. Neurosurgery. 2010;67(4):935–9.CrossRef Harrigan MR, Rajneesh KF, Ardelt AA, Fisher WS. Short-term antifibrinolytic therapy before early aneurysm treatment in subarachnoid hemorrhage: effects on rehemorrhage, cerebral ischemia, and hydrocephalus. Neurosurgery. 2010;67(4):935–9.CrossRef
20.
go back to reference Brown JR, Birkmeyer NJ, O’Connor GT. Meta-analysis comparing the effectiveness and adverse outcomes of antifibrinolytic agents in cardiac surgery. Circulation. 2007;115(22):2801–13.CrossRef Brown JR, Birkmeyer NJ, O’Connor GT. Meta-analysis comparing the effectiveness and adverse outcomes of antifibrinolytic agents in cardiac surgery. Circulation. 2007;115(22):2801–13.CrossRef
21.
go back to reference Collaborators C-T, Shakur H, Roberts I, et al. Effects of tranexamic acid on death, vascular occlusive events, and blood transfusion in trauma patients with significant haemorrhage (CRASH-2): a randomised, placebo-controlled trial. Lancet. 2010;376(9734):23–32.CrossRef Collaborators C-T, Shakur H, Roberts I, et al. Effects of tranexamic acid on death, vascular occlusive events, and blood transfusion in trauma patients with significant haemorrhage (CRASH-2): a randomised, placebo-controlled trial. Lancet. 2010;376(9734):23–32.CrossRef
22.
go back to reference Dalmau A, Sabate A, Acosta F, et al. Tranexamic acid reduces red cell transfusion better than epsilon-aminocaproic acid or placebo in liver transplantation. Anesth Analg. 2000;91(1):29–34.CrossRef Dalmau A, Sabate A, Acosta F, et al. Tranexamic acid reduces red cell transfusion better than epsilon-aminocaproic acid or placebo in liver transplantation. Anesth Analg. 2000;91(1):29–34.CrossRef
23.
go back to reference Ducloy-Bouthors AS, Jude B, Duhamel A, et al. High-dose tranexamic acid reduces blood loss in postpartum haemorrhage. Crit Care. 2011;15(2):R117.CrossRef Ducloy-Bouthors AS, Jude B, Duhamel A, et al. High-dose tranexamic acid reduces blood loss in postpartum haemorrhage. Crit Care. 2011;15(2):R117.CrossRef
24.
go back to reference Kagoma YK, Crowther MA, Douketis J, Bhandari M, Eikelboom J, Lim W. Use of antifibrinolytic therapy to reduce transfusion in patients undergoing orthopedic surgery: a systematic review of randomized trials. Thromb Res. 2009;123(5):687–96.CrossRef Kagoma YK, Crowther MA, Douketis J, Bhandari M, Eikelboom J, Lim W. Use of antifibrinolytic therapy to reduce transfusion in patients undergoing orthopedic surgery: a systematic review of randomized trials. Thromb Res. 2009;123(5):687–96.CrossRef
25.
go back to reference Mangano DT, Tudor IC, Dietzel C, Multicenter Study of Perioperative Ischemia Research G, Ischemia R, Education F. The risk associated with aprotinin in cardiac surgery. N Engl J Med. 2006;354(4):353–65.CrossRef Mangano DT, Tudor IC, Dietzel C, Multicenter Study of Perioperative Ischemia Research G, Ischemia R, Education F. The risk associated with aprotinin in cardiac surgery. N Engl J Med. 2006;354(4):353–65.CrossRef
26.
go back to reference •• Cheriyan T, Maier SP, Bianco K, et al. Efficacy of tranexamic acid on surgical bleeding in spine surgery: a meta-analysis. Spine J 2015;15(4):752–61. A meta-analysis of randomized controlled trails done before January 2014 was done to investigate the effectiveness of tranexamic acid use on reducing blood loss in spine surgery. Eleven randomized controlled trials were included. Tranexamic acid was found to significantly reduce intraoperative, postoperative and total blood loss when compared to placebo. Tranexamic acid also reduced the amount of blood transfusions when compared to placebo. CrossRef •• Cheriyan T, Maier SP, Bianco K, et al. Efficacy of tranexamic acid on surgical bleeding in spine surgery: a meta-analysis. Spine J 2015;15(4):752–61. A meta-analysis of randomized controlled trails done before January 2014 was done to investigate the effectiveness of tranexamic acid use on reducing blood loss in spine surgery. Eleven randomized controlled trials were included. Tranexamic acid was found to significantly reduce intraoperative, postoperative and total blood loss when compared to placebo. Tranexamic acid also reduced the amount of blood transfusions when compared to placebo. CrossRef
27.
go back to reference Gill JB, Chin Y, Levin A, Feng D. The use of antifibrinolytic agents in spine surgery. A meta-analysis. J Bone Joint Surg Am Vol. 2008;90(11):2399–407.CrossRef Gill JB, Chin Y, Levin A, Feng D. The use of antifibrinolytic agents in spine surgery. A meta-analysis. J Bone Joint Surg Am Vol. 2008;90(11):2399–407.CrossRef
28.
go back to reference Halanski M, Cassidy JA, Hezel S, Reischmann D, Hassan N. The efficacy of amicar versus tranexamic acid in pediatric spinal deformity surgery: a prospective, randomized double-blinded pilot study. Spinal Deform. 2014;2(3):191–7.CrossRef Halanski M, Cassidy JA, Hezel S, Reischmann D, Hassan N. The efficacy of amicar versus tranexamic acid in pediatric spinal deformity surgery: a prospective, randomized double-blinded pilot study. Spinal Deform. 2014;2(3):191–7.CrossRef
29.
go back to reference •• Peters A, Verma K, Slobodyanyuk K, et al. Antifibrinolytics reduce blood loss in adult spinal deformity surgery. Spine 2015;40(8):E443–49. Prospective, randomized, double-blinded comparison for tranexamic acid, aminocaproic acid and placebo in patients undergoing adult spinal deformity. Total blood loss was reduced in patients who received aminocaproic acid when compared to placebo and amiocaproic acid treated patients had significantly fewer blood transfusions than tranexamic acid treated patients. CrossRef •• Peters A, Verma K, Slobodyanyuk K, et al. Antifibrinolytics reduce blood loss in adult spinal deformity surgery. Spine 2015;40(8):E443–49. Prospective, randomized, double-blinded comparison for tranexamic acid, aminocaproic acid and placebo in patients undergoing adult spinal deformity. Total blood loss was reduced in patients who received aminocaproic acid when compared to placebo and amiocaproic acid treated patients had significantly fewer blood transfusions than tranexamic acid treated patients. CrossRef
30.
go back to reference Roth S, Thisted RA, Erickson JP, Black S, Schreider BD. Eye injuries after nonocular surgery. A study of 60,965 anesthetics from 1988 to 1992. Anesthesiology. 1996;85(5):1020–7.CrossRef Roth S, Thisted RA, Erickson JP, Black S, Schreider BD. Eye injuries after nonocular surgery. A study of 60,965 anesthetics from 1988 to 1992. Anesthesiology. 1996;85(5):1020–7.CrossRef
31.
go back to reference Stevens WR, Glazer PA, Kelley SD, Lietman TM, Bradford DS. Ophthalmic complications after spinal surgery. Spine. 1997;22(12):1319–24.CrossRef Stevens WR, Glazer PA, Kelley SD, Lietman TM, Bradford DS. Ophthalmic complications after spinal surgery. Spine. 1997;22(12):1319–24.CrossRef
32.
go back to reference Shen Y, Drum M, Roth S. The prevalence of perioperative visual loss in the United States: a 10-year study from 1996 to 2005 of spinal, orthopedic, cardiac, and general surgery. Anesth Analg. 2009;109(5):1534–45.CrossRef Shen Y, Drum M, Roth S. The prevalence of perioperative visual loss in the United States: a 10-year study from 1996 to 2005 of spinal, orthopedic, cardiac, and general surgery. Anesth Analg. 2009;109(5):1534–45.CrossRef
33.
go back to reference Newman NJ. Perioperative visual loss after nonocular surgeries. Am J Ophthalmol. 2008;145(4):604–10.CrossRef Newman NJ. Perioperative visual loss after nonocular surgeries. Am J Ophthalmol. 2008;145(4):604–10.CrossRef
34.
go back to reference American Society of Anesthesiologists Task Force on Perioperative B. Practice advisory for perioperative visual loss associated with spine surgery: a report by the American Society of anesthesiologists task force on perioperative blindness. Anesthesiology. 2006;104(6):1319–28.CrossRef American Society of Anesthesiologists Task Force on Perioperative B. Practice advisory for perioperative visual loss associated with spine surgery: a report by the American Society of anesthesiologists task force on perioperative blindness. Anesthesiology. 2006;104(6):1319–28.CrossRef
35.
go back to reference •• American Society of Anesthesiologists Task Force on Perioperative Visual L. Practice advisory for perioperative visual loss associated with spine surgery: an updated report by the American Society of Anesthesiologists Task Force on Perioperative Visual Loss. Anesthesiology 2012; 116(2): 274–85. Updated practice advisory by the American Society of Anesthesiologists. The Task Force agreed that preoperative anemia, prolonged procedures (>6.5 hours), procedures with extensive blood loss and procedures which are both prolonged and with extensive blood loss all increased the risk of postoperative visual loss. The Task Force recommended using colloids in addition to crystalloids, monitoring of hemoglobin or hematocrit, avoiding direct pressure on the eye, positioning the head at or above the level of the heart with the neck in a neutral position. •• American Society of Anesthesiologists Task Force on Perioperative Visual L. Practice advisory for perioperative visual loss associated with spine surgery: an updated report by the American Society of Anesthesiologists Task Force on Perioperative Visual Loss. Anesthesiology 2012; 116(2): 274–85. Updated practice advisory by the American Society of Anesthesiologists. The Task Force agreed that preoperative anemia, prolonged procedures (>6.5 hours), procedures with extensive blood loss and procedures which are both prolonged and with extensive blood loss all increased the risk of postoperative visual loss. The Task Force recommended using colloids in addition to crystalloids, monitoring of hemoglobin or hematocrit, avoiding direct pressure on the eye, positioning the head at or above the level of the heart with the neck in a neutral position.
36.
go back to reference Lee LA, Roth S, Todd MM, et al. Risk factors associated with ischemic optic neuropathy after spinal fusion surgery. Anesthesiology. 2012;116(1):15–24. Lee LA, Roth S, Todd MM, et al. Risk factors associated with ischemic optic neuropathy after spinal fusion surgery. Anesthesiology. 2012;116(1):15–24.
37.
go back to reference Roth S. Perioperative visual loss: what do we know, what can we do? Br J Anaesth. 2009;103(Suppl 1):i31–40.CrossRef Roth S. Perioperative visual loss: what do we know, what can we do? Br J Anaesth. 2009;103(Suppl 1):i31–40.CrossRef
Metadata
Title
Minimizing Complications in Major Spine Surgery: The Role of the Anesthesiologist
Authors
Koffi M. Kla
Lorri A. Lee
Publication date
01-09-2016
Publisher
Springer US
Published in
Current Anesthesiology Reports / Issue 3/2016
Electronic ISSN: 2167-6275
DOI
https://doi.org/10.1007/s40140-016-0168-3

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