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Published in: Archives of Osteoporosis 1/2017

01-12-2017 | Original Article

Minimal-trauma ankle fractures predominate during pregnancy: a 17-year retrospective study

Authors: Madhuni Herath, Phillip Wong, Anne Trinh, Carolyn A. Allan, Euan M. Wallace, Peter R. Ebeling, Peter J. Fuller, Frances Milat

Published in: Archives of Osteoporosis | Issue 1/2017

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Abstract

Summary

This study assessed all fractures occurring in pregnancy at a tertiary referral centre over a 17-year period. Most fractures were due to minimal trauma, and those involving the ankle were the most common. Women tended to fracture during their second and third trimesters and most required surgical intervention during pregnancy.

Purpose

To characterise fractures in pregnancy over a 17-year period at a tertiary referral health service.

Methods

Medical records at the Monash Health in Australia were examined from 2000–2016 for fractures in pregnancy using the birthing outcome system database and the tenth revision of the International Statistical Classification of Diseases and Related Health Problems coding. Site, mechanism, investigations, management and outcomes were documented.

Results

Of the 114,673 live births during this period, 33 women (mean age 30.3 ± 1.9 years) were identified with fracture in pregnancy (~ 2.9 maternal fractures/10,000 live births). Minimal-trauma fractures (MTFs) occurred in 28 women whilst 5 were due to motor vehicle accidents. Of the MTF, 2/28 (7.1%), 13/28 (46.4%) and 13/28 (46.4%) occurred in the first, second and third trimesters, respectively. MTF involved the lower limb (60.7%), upper limb (25.0%), ribs (10.7%) and clavicle (3.6%). The ankle was involved in 39.3% of MTFs. Diabetes (14.3%), asthma (10.7%) and thyroid dysfunction (7.1%) affected these women with MTF; vitamin D levels were not routinely measured. Surgical interventions requiring anaesthesia were required in 57.1% with MTF: 50.0% during their second, 31.3% in their third and 12.5% in their first trimesters; 6.3% had surgery post partum. Pre-term birth and emergency caesarean section complicated 6/28 (21.4%) of MTF pregnancies. One patient received post-partum bisphosphonate therapy; only two 2/32 (6.25%) received medical follow-up.

Conclusions

Fractures in pregnancy are uncommon. Lower limb fractures are frequently due to minimal trauma, and surgical intervention is often required. The low rate of medical follow-up in MTF is of concern and reinforces the need for greater recognition of potential osteoporosis in this population.
Literature
1.
go back to reference Albright F, Reifenstein EC (1949) The parathyroid glands and metabolic bone disease. Selected studies. Am J Med 7:844 Albright F, Reifenstein EC (1949) The parathyroid glands and metabolic bone disease. Selected studies. Am J Med 7:844
3.
go back to reference Kovacs CS, Ralston SH (2015) Presentation and management of osteoporosis presenting in association with pregnancy or lactation. Osteoporos Int 26(9):2223–2241CrossRefPubMed Kovacs CS, Ralston SH (2015) Presentation and management of osteoporosis presenting in association with pregnancy or lactation. Osteoporos Int 26(9):2223–2241CrossRefPubMed
4.
go back to reference Maliha G, Morgan J, Vrahas M (2012) Transient osteoporosis of pregnancy. Injury, Int J Care Injured 43:1237–1241CrossRef Maliha G, Morgan J, Vrahas M (2012) Transient osteoporosis of pregnancy. Injury, Int J Care Injured 43:1237–1241CrossRef
5.
go back to reference Cakmak B, Ribeiro AP, Inanir A (2016) Postural balance and the risk of falling during pregnancy. J Matern Fetal Neonatal Med 29(10):1623–1625PubMed Cakmak B, Ribeiro AP, Inanir A (2016) Postural balance and the risk of falling during pregnancy. J Matern Fetal Neonatal Med 29(10):1623–1625PubMed
6.
go back to reference McCrory JL, Chambers AJ, Daftary A, Redfern MS (2010) Dynamic postural stability during advancing pregnancy. J Biomech 43:2434–2439CrossRefPubMed McCrory JL, Chambers AJ, Daftary A, Redfern MS (2010) Dynamic postural stability during advancing pregnancy. J Biomech 43:2434–2439CrossRefPubMed
7.
go back to reference Sanz-Salvador L, Garcia-Perez MA, Tarin JJ, Cano A (2015) Bone metabolic changes during pregnancy: a period of vulnerability to osteoporosis and fracture. Eur J Endocrinol 172(2):R53–R65CrossRefPubMed Sanz-Salvador L, Garcia-Perez MA, Tarin JJ, Cano A (2015) Bone metabolic changes during pregnancy: a period of vulnerability to osteoporosis and fracture. Eur J Endocrinol 172(2):R53–R65CrossRefPubMed
8.
go back to reference More C, Bettembuk P, Bhattoa HP, Balogh A (2001) The effects of pregnancy and lactation on bone mineral density. Osteoporos Int 12(9):732–737CrossRefPubMed More C, Bettembuk P, Bhattoa HP, Balogh A (2001) The effects of pregnancy and lactation on bone mineral density. Osteoporos Int 12(9):732–737CrossRefPubMed
9.
go back to reference Chatterjee S, Kotelchuck M, Sambamoorthi U (2008) Prevalence of chronic illness in pregnancy, access to care, and health care costs: implications for interconception care. Womens Health Issues 18(6):107–116CrossRef Chatterjee S, Kotelchuck M, Sambamoorthi U (2008) Prevalence of chronic illness in pregnancy, access to care, and health care costs: implications for interconception care. Womens Health Issues 18(6):107–116CrossRef
10.
go back to reference Mendez-Figueroa H, Dahlke JD, Vrees RA, Rouse DJ (2013) Trauma in pregnancy: an updated systematic review. Am J Obstet Gynecol 209(1):1–10CrossRefPubMed Mendez-Figueroa H, Dahlke JD, Vrees RA, Rouse DJ (2013) Trauma in pregnancy: an updated systematic review. Am J Obstet Gynecol 209(1):1–10CrossRefPubMed
11.
go back to reference Hadji P, Boekhoff J, Hahn M, Hellmeyer L, Hars O, Kyvernitakis I (2017) Pregnancy-associated osteoporosis: a case-control study. Osteoporos Int 28(4):1393–1399CrossRefPubMed Hadji P, Boekhoff J, Hahn M, Hellmeyer L, Hars O, Kyvernitakis I (2017) Pregnancy-associated osteoporosis: a case-control study. Osteoporos Int 28(4):1393–1399CrossRefPubMed
12.
go back to reference Kovacs C (2016) Maternal mineral and bone metabolism during pregnancy, lactation and post-weaning recovery. Physiol Rev 96(2):449–547CrossRefPubMed Kovacs C (2016) Maternal mineral and bone metabolism during pregnancy, lactation and post-weaning recovery. Physiol Rev 96(2):449–547CrossRefPubMed
13.
go back to reference Schiff MA (2008) Pregnancy outcomes following hospitalisation for a fall in Washington state from 1987–2004. BJOG 115:1648–1654CrossRefPubMed Schiff MA (2008) Pregnancy outcomes following hospitalisation for a fall in Washington state from 1987–2004. BJOG 115:1648–1654CrossRefPubMed
14.
go back to reference Cannada LK, Pan P, Casey BM, McIntire DD, Shafi S, Leveno KJ (2010) Pregnancy outcomes after orthopedic trauma. J Trauma 69:694–698CrossRefPubMed Cannada LK, Pan P, Casey BM, McIntire DD, Shafi S, Leveno KJ (2010) Pregnancy outcomes after orthopedic trauma. J Trauma 69:694–698CrossRefPubMed
15.
go back to reference Dunning K, LeMasters G, Bhattacharya A (2010) A major public health issue: the high incidence of falls during pregnancy. Matern Child Health J 14:720–725CrossRefPubMed Dunning K, LeMasters G, Bhattacharya A (2010) A major public health issue: the high incidence of falls during pregnancy. Matern Child Health J 14:720–725CrossRefPubMed
16.
go back to reference Eastell R, Reid DM, Compston J, Cooper C, Fogelman I, Francis RM, Hay SM, Hosking DJ, Purdie DW, Ralston SH, Reeve J, Russell RGG, Stevenson JC (2001) Secondary prevention of osteoporosis: when should a non-vertebral fracture be a trigger for action? Q J Med 94:575–597CrossRef Eastell R, Reid DM, Compston J, Cooper C, Fogelman I, Francis RM, Hay SM, Hosking DJ, Purdie DW, Ralston SH, Reeve J, Russell RGG, Stevenson JC (2001) Secondary prevention of osteoporosis: when should a non-vertebral fracture be a trigger for action? Q J Med 94:575–597CrossRef
17.
go back to reference Pritchard JM, Giangregorio LM, Ioannidis G, Papaioannou A, Adachi JD, Leslie WD (2012) Ankle fractures do not predict osteoporotic fractures in women with or without fractures. Osteoporos Int 23:957–962CrossRefPubMed Pritchard JM, Giangregorio LM, Ioannidis G, Papaioannou A, Adachi JD, Leslie WD (2012) Ankle fractures do not predict osteoporotic fractures in women with or without fractures. Osteoporos Int 23:957–962CrossRefPubMed
18.
go back to reference Biver E, Durosier C, Chevalley T, Hermann FR, Ferrari S, Rizzoli R (2015) Prior ankle fractures in postmenopausal women are associated with low areal bone mineral density and bone microstructure alterations. Osteoporos Int 26:2147–2155CrossRefPubMed Biver E, Durosier C, Chevalley T, Hermann FR, Ferrari S, Rizzoli R (2015) Prior ankle fractures in postmenopausal women are associated with low areal bone mineral density and bone microstructure alterations. Osteoporos Int 26:2147–2155CrossRefPubMed
19.
go back to reference Stein EM, Liu XS, Nickolas TL, Cohen A, Thomas V, McMahon DJ, Zhang C, Cosman F, Nieves J, Greisberg J, Guo XE, Shane E (2011) Abnormal microarchitecture and stiffness in postmenopausal women with ankle fractures. J Clin Endocrinol Metabol 96(7):2041–2048CrossRef Stein EM, Liu XS, Nickolas TL, Cohen A, Thomas V, McMahon DJ, Zhang C, Cosman F, Nieves J, Greisberg J, Guo XE, Shane E (2011) Abnormal microarchitecture and stiffness in postmenopausal women with ankle fractures. J Clin Endocrinol Metabol 96(7):2041–2048CrossRef
20.
go back to reference Shahtaheri SM, Aaron JE, Johnson DR, Purdie DW (1999) Changes in trabecular bone architecture in women during pregnancy. Br J Obstet Gynaecol 106(5):432–438CrossRefPubMed Shahtaheri SM, Aaron JE, Johnson DR, Purdie DW (1999) Changes in trabecular bone architecture in women during pregnancy. Br J Obstet Gynaecol 106(5):432–438CrossRefPubMed
21.
go back to reference Wisser J, Florio I, Neff M, Konig V, Huch R, Huch A, Mandach UV (2005) Changes in bone density and metabolism in pregnancy. Acta Obstet Gynecol Scand 84:349–354CrossRefPubMed Wisser J, Florio I, Neff M, Konig V, Huch R, Huch A, Mandach UV (2005) Changes in bone density and metabolism in pregnancy. Acta Obstet Gynecol Scand 84:349–354CrossRefPubMed
22.
go back to reference Ulrich U, Miller PB, Eyre DR, Chesnut CH, Schlebusch H, Soues MR (2003) Bone remodelling and bone mineral density during pregnancy. Arch Gynecol Obstet 268:309–316CrossRefPubMed Ulrich U, Miller PB, Eyre DR, Chesnut CH, Schlebusch H, Soues MR (2003) Bone remodelling and bone mineral density during pregnancy. Arch Gynecol Obstet 268:309–316CrossRefPubMed
23.
go back to reference Styczynska H, Lis K, Sobanska I, Pater A, Pollak J, Mankowska A (2009) Bone turnover markers and osteoprotegerin in uncomplicated pregnancy. Electron J Int Fed Clin Chem Lab Med 19(4):193–202 Styczynska H, Lis K, Sobanska I, Pater A, Pollak J, Mankowska A (2009) Bone turnover markers and osteoprotegerin in uncomplicated pregnancy. Electron J Int Fed Clin Chem Lab Med 19(4):193–202
24.
go back to reference Dieguez M, Herrero A, Avello N, Suarez P, Delgado E, Menendez E (2016) Prevalence of thyroid dysfunction in women in early pregnancy: does it increase with maternal age? Clin Endocrinol 84(1):121–126CrossRef Dieguez M, Herrero A, Avello N, Suarez P, Delgado E, Menendez E (2016) Prevalence of thyroid dysfunction in women in early pregnancy: does it increase with maternal age? Clin Endocrinol 84(1):121–126CrossRef
25.
go back to reference Negro R, H MJ (2011) Thyroid disease in pregnancy. Best Pract Res Clin Endocrinol Metab 25(6):927–943CrossRefPubMed Negro R, H MJ (2011) Thyroid disease in pregnancy. Best Pract Res Clin Endocrinol Metab 25(6):927–943CrossRefPubMed
26.
27.
go back to reference World Health Organization (2016) Diabetes country profiles 2016—Australia, Geneva World Health Organization (2016) Diabetes country profiles 2016—Australia, Geneva
28.
go back to reference Australian Bureau of Statistics (2015) National health survey: first results, 2014–15. Cat. No. 4363.0.55.001;. ABS, Canberra Australian Bureau of Statistics (2015) National health survey: first results, 2014–15. Cat. No. 4363.0.55.001;. ABS, Canberra
29.
go back to reference Templeton M, Pieris-Caldwell I (2008) Gestational diabetes mellitus in Australia, 2005-06. Cat. no. CVD 44. Australian Institute of Health and Welfare Templeton M, Pieris-Caldwell I (2008) Gestational diabetes mellitus in Australia, 2005-06. Cat. no. CVD 44. Australian Institute of Health and Welfare
30.
go back to reference Australian Institute of Health and Welfare (2016) Australia’s mothers and babies 2014: in brief. Perinatal statistics series no. 32 Cat no. PER 87. AIHW, Canberra Australian Institute of Health and Welfare (2016) Australia’s mothers and babies 2014: in brief. Perinatal statistics series no. 32 Cat no. PER 87. AIHW, Canberra
31.
32.
go back to reference Baldwin EA, Borowski KS, Brost BC, Rose CH (2015) Antepartum nonobstetrical surgery at >/= 23 weeks’ gestation and risk for preterm delivery. Am J Obstet Gynecol 212(232):e1–e5 Baldwin EA, Borowski KS, Brost BC, Rose CH (2015) Antepartum nonobstetrical surgery at >/= 23 weeks’ gestation and risk for preterm delivery. Am J Obstet Gynecol 212(232):e1–e5
33.
go back to reference Bhattee G, Rahman MS, Rahman J (2009) Open reduction and internal fixation of an acetabular fracture in pregnancy: a case report. Curr Orthop Pract 20(3):329–330CrossRef Bhattee G, Rahman MS, Rahman J (2009) Open reduction and internal fixation of an acetabular fracture in pregnancy: a case report. Curr Orthop Pract 20(3):329–330CrossRef
34.
go back to reference American College of Obstetricians and Gynecologists (2017) Nonobstetric surgery during pregnancy. Committee Opinion No. 696. Obstet Gynecol 129:777–778CrossRef American College of Obstetricians and Gynecologists (2017) Nonobstetric surgery during pregnancy. Committee Opinion No. 696. Obstet Gynecol 129:777–778CrossRef
35.
go back to reference Phillips AJ, Ostlere SJ, Smith R (2000) Pregnancy-associated osteoporosis: does the skeleton recover? Osteoporos Int 11:449–454CrossRefPubMed Phillips AJ, Ostlere SJ, Smith R (2000) Pregnancy-associated osteoporosis: does the skeleton recover? Osteoporos Int 11:449–454CrossRefPubMed
36.
go back to reference Salles JP (2016) Bone metabolism during pregnancy. Ann Endocrinol 77:163–168CrossRef Salles JP (2016) Bone metabolism during pregnancy. Ann Endocrinol 77:163–168CrossRef
37.
go back to reference Pediatrics AAo (2012) Breastfeeding and the use of human milk. Pediatrics 129(3):e827–e841CrossRef Pediatrics AAo (2012) Breastfeeding and the use of human milk. Pediatrics 129(3):e827–e841CrossRef
38.
go back to reference Patlas N, Golomb G, Yaffe P, Pinto T, Breuer E, Ornoy A (1999) Transplacental effects of bisphosphonates on fetal skeletal ossification and mineralization in rats. Teratology 60:68–73CrossRefPubMed Patlas N, Golomb G, Yaffe P, Pinto T, Breuer E, Ornoy A (1999) Transplacental effects of bisphosphonates on fetal skeletal ossification and mineralization in rats. Teratology 60:68–73CrossRefPubMed
Metadata
Title
Minimal-trauma ankle fractures predominate during pregnancy: a 17-year retrospective study
Authors
Madhuni Herath
Phillip Wong
Anne Trinh
Carolyn A. Allan
Euan M. Wallace
Peter R. Ebeling
Peter J. Fuller
Frances Milat
Publication date
01-12-2017
Publisher
Springer London
Published in
Archives of Osteoporosis / Issue 1/2017
Print ISSN: 1862-3522
Electronic ISSN: 1862-3514
DOI
https://doi.org/10.1007/s11657-017-0380-x

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