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BMC Complementary Medicine and Therapies

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01-12-2020 | Mild Neurocognitive Disorder | Research article

The effects of six months Persicaria minor extract supplement among older adults with mild cognitive impairment: a double-blinded, randomized, and placebo-controlled trial

Authors: Huijin Lau, Suzana Shahar, Mazlyfarina Mohamad, Nor Fadilah Rajab, Hanis Mastura Yahya, Normah Che Din, Hamzaini Abdul Hamid

Published in: BMC Complementary Medicine and Therapies | Issue 1/2020

Abstract

Background

Persicaria minor extract exhibits antioxidant and anti-inflammatory properties and has potential effects on cognitive function and mood. However, the effects of P.minor on brain activation and biomarkers have not been studied among older adults. This multicentre, randomized, double-blinded, placebo-controlled study aimed to investigate the effect of 6 months P.minor extract supplement (Biokesum®) on cognition, mood, biomarkers, and brain activation among older adults with Mild Cognitive Impairment (MCI).

Method

A total of 36 Malaysian community-dwelling older adults with MCI (60–75-year-old) were randomized into Biokesum® (n = 18) and placebo group (n = 18). Each subject consumed one capsule of Biokesum® (250 mg/capsule) or placebo (maltodextrin, 280 mg/capsule) twice daily for 6 months. Cognitive function and mood were assessed at baseline, 3rd, and 6th-month using neuropsychological tests (MMSE, Digit Span, RAVLT, Digit Symbol, and Visual Reproduction) and Profile of Mood State (POMS) questionnaire. Blood lipid profile, fasting blood glucose, and biomarkers (MDA, LPO, COX-2, iNOS, and BDNF) were measured at baseline and 6th month. By the end of the intervention, there were 30 compliers (Biokesum®: N = 15; Placebo: N = 15) and 6 dropouts. For brain activation assessment, 15 subsamples (Biokesum®: N = 8; Placebo: N = 7) completed N-back and Stroop tasks during fMRI scanning at baseline and 6th month. The dorsolateral prefrontal cortex (Brodmann’s area 9 and 46) was identified as a region of interest (ROI) for brain activation analysis using SPM software.

Results

Two-way mixed ANOVA analysis showed significant improvements in Visual Reproduction II (p = 0.012, partial η² = 0.470), tension (p = 0.042, partial η² = 0.147), anger (p = 0.010, partial η² = 0.207), confusion (p = 0.041, partial η² = 0.148), total negative subscales (p = 0.043, partial η² = 0.145), BDNF (p = 0.020, partial η² = 0.179) and triglyceride (p = 0.029, partial η² = 0.237) following 6 months of Biokesum® supplementation. Preliminary finding also demonstrated significant improvement at 0-back task-induced right DLPFC activation (p = 0.028, partial η² = 0.652) among subsamples in Biokesum® group. No adverse events were reported at the end of the study.

Conclusion

Six months Biokesum® supplementation potentially improved visual memory, negative mood, BDNF, and triglyceride levels among older adults with MCI. Significant findings on brain activation at the right DPLFC must be considered as preliminary.

Trial registration

Retrospectively registered on 30th August 2019 [ISRC TN12417552].

Available only for authorised users

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Title: The effects of six months Persicaria minor extract supplement among older adults with mild cognitive impairment: a double-blinded, randomized, and placebo-controlled trial
Authors: Huijin Lau
Suzana Shahar
Mazlyfarina Mohamad
Nor Fadilah Rajab
Hanis Mastura Yahya
Normah Che Din
Hamzaini Abdul Hamid
Publication date: 01-12-2020
Publisher: BioMed Central
Keyword: Mild Neurocognitive Disorder
Published in: BMC Complementary Medicine and Therapies / Issue 1/2020
Electronic ISSN: 2662-7671
DOI: https://doi.org/10.1186/s12906-020-03092-2

Keynote webinar | Spotlight on medication adherence

Springer Medicine

The effects of six months Persicaria minor extract supplement among older adults with mild cognitive impairment: a double-blinded, randomized, and placebo-controlled trial

Abstract

Background

Method

Results

Conclusion

Trial registration

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Method

Results

Conclusion

Trial registration

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