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CardioVascular and Interventional Radiology

Published in:

01-04-2011 | Clinical Investigation

Midterm Results of Uterine Artery Embolization Using Narrow-Size Calibrated Embozene Microspheres

Authors: Ulrike Stampfl, Boris Radeleff, Christof Sommer, Sibylle Stampfl, Angelika Dahlke, Nadine Bellemann, Hans-Ulrich Kauczor, Goetz M. Richter

Published in: CardioVascular and Interventional Radiology | Issue 2/2011

Abstract

Purpose

To evaluate safety and efficacy of uterine artery embolization using narrow-size-range polyphosphazene-coated hydrogel microspheres (Embozene, CeloNova Biosciences, Newnan, GA).

Methods

Between May 2006 and September 2008, a total of 121 consecutive patients (mean ± SD age 42.1 ± 5.4 years, range 30.5–51.5 years) were enrolled onto this single-center study. The primary study endpoint was safety as assessed by the society of interventional radiology (SIR) classification. The secondary endpoint was efficacy, which was based on a 1-year magnetic resonance imaging study and relief of symptoms documented by the Medical Outcomes Study 36-Item Short-Form Health Survey questionnaire over a 2-year interval.

Results

The mean ± SD diameter of the dominant fibroid was 6.4 ± 2.6 (range, 2.9–13.9) cm and the mean volume 137.2 ± 245.1 (range, 5.3–1184) ml. Most patients had multiple fibroids with 11% more than 10. A total of 240 of 242 interventions were completed as planned, a technical success rate of 99.2%. According to the SIR classification, one type A, eight type C, and one type D complication occurred. Total devascularization was noted in 96% (116 of 121) of dominant fibroids. Volume decrease was 4% at 2 weeks, 52% (P < 0.001) at 3 months, 78% (P < 0.001) at 6 months, and 91% at 12 months (P < 0.001). The latter difference was statistically significant (P = 0.007). A total of 92% had improved hypermenorrhea at 1 year and 94% at 2 years. Dysmenorrhea was improved in 96% at 1 year and in 95% at 2 years. The overall health status score was 60.4 ± 26.2 points at baseline and 96.9 ± 3.8 after 1 year (P = 0.0019).

Conclusion

Uterine artery embolization with Embozene microspheres is a safe procedure. Its efficacy is demonstrated by high fibroid devascularization and volume reduction rates and significant improvements of clinical symptoms and quality-of-life scores during follow-up.

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Title: Midterm Results of Uterine Artery Embolization Using Narrow-Size Calibrated Embozene Microspheres
Authors: Ulrike Stampfl
Boris Radeleff
Christof Sommer
Sibylle Stampfl
Angelika Dahlke
Nadine Bellemann
Hans-Ulrich Kauczor
Goetz M. Richter
Publication date: 01-04-2011
Publisher: Springer-Verlag
Published in: CardioVascular and Interventional Radiology / Issue 2/2011
Print ISSN: 0174-1551
Electronic ISSN: 1432-086X
DOI: https://doi.org/10.1007/s00270-010-9986-8

2024 ASCO Annual Meeting

Springer Medicine

Midterm Results of Uterine Artery Embolization Using Narrow-Size Calibrated Embozene Microspheres

Abstract

Purpose

Methods

Results

Conclusion

2024 ASCO Annual Meeting

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusion

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