Midregional pro-adrenomedullin and copeptin: exercise kinetics and association with the cardiopulmonary exercise response in comparison to B-type natriuretic peptide

go back to reference Alehagen U, Dahlstrom U, Rehfeld JF, Goetze JP (2011) Association of copeptin and N-terminal proBNP concentrations with risk of cardiovascular death in older patients with symptoms of heart failure. JAMA 305:2088–2095PubMedCrossRef Alehagen U, Dahlstrom U, Rehfeld JF, Goetze JP (2011) Association of copeptin and N-terminal proBNP concentrations with risk of cardiovascular death in older patients with symptoms of heart failure. JAMA 305:2088–2095PubMedCrossRef

go back to reference DeLong ER, DeLong DM, Clarke-Pearson DL (1988) Comparing the areas under two or more correlated receiver operating characteristic curves: a nonparametric approach. Biometrics 44:837–845PubMedCrossRef DeLong ER, DeLong DM, Clarke-Pearson DL (1988) Comparing the areas under two or more correlated receiver operating characteristic curves: a nonparametric approach. Biometrics 44:837–845PubMedCrossRef

go back to reference Elmas E, Lang S, Dempfle CE, Kalsch T, Papassotiriou J, Morgenthaler NG, Borggrefe M, Brueckmann M (2008) Diagnostic performance of mid-regional pro-adrenomedullin as an analyte for the exclusion of left ventricular dysfunction. Int J Cardiol 128:107–111PubMedCrossRef Elmas E, Lang S, Dempfle CE, Kalsch T, Papassotiriou J, Morgenthaler NG, Borggrefe M, Brueckmann M (2008) Diagnostic performance of mid-regional pro-adrenomedullin as an analyte for the exclusion of left ventricular dysfunction. Int J Cardiol 128:107–111PubMedCrossRef

go back to reference Fleisher LA, Beckman JA, Brown KA, Calkins H, Chaikof E, Fleischmann KE, Freeman WK, Froehlich JB, Kasper EK, Kersten JR, Riegel B, Robb JF, Smith SC Jr, Jacobs AK, Adams CD, Anderson JL, Antman EM, Buller CE, Creager MA, Ettinger SM, Faxon DP, Fuster V, Halperin JL, Hiratzka LF, Hunt SA, Lytle BW, Nishimura R, Ornato JP, Page RL, Tarkington LG, Yancy CW (2007) ACC/AHA 2007 Guidelines on perioperative cardiovascular evaluation and care for noncardiac surgery: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Writing Committee to Revise the 2002 Guidelines on Perioperative Cardiovascular Evaluation for Noncardiac Surgery): developed in collaboration with the American Society of Echocardiography, American Society of Nuclear Cardiology, Heart Rhythm Society, Society of Cardiovascular Anesthesiologists, Society for Cardiovascular Angiography and Interventions, Society for Vascular Medicine and Biology, and Society for Vascular Surgery. Circulation 116:e418–e499PubMedCrossRef Fleisher LA, Beckman JA, Brown KA, Calkins H, Chaikof E, Fleischmann KE, Freeman WK, Froehlich JB, Kasper EK, Kersten JR, Riegel B, Robb JF, Smith SC Jr, Jacobs AK, Adams CD, Anderson JL, Antman EM, Buller CE, Creager MA, Ettinger SM, Faxon DP, Fuster V, Halperin JL, Hiratzka LF, Hunt SA, Lytle BW, Nishimura R, Ornato JP, Page RL, Tarkington LG, Yancy CW (2007) ACC/AHA 2007 Guidelines on perioperative cardiovascular evaluation and care for noncardiac surgery: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Writing Committee to Revise the 2002 Guidelines on Perioperative Cardiovascular Evaluation for Noncardiac Surgery): developed in collaboration with the American Society of Echocardiography, American Society of Nuclear Cardiology, Heart Rhythm Society, Society of Cardiovascular Anesthesiologists, Society for Cardiovascular Angiography and Interventions, Society for Vascular Medicine and Biology, and Society for Vascular Surgery. Circulation 116:e418–e499PubMedCrossRef

go back to reference Fletcher GF, Balady GJ, Amsterdam EA, Chaitman B, Eckel R, Fleg J, Froelicher VF, Leon AS, Piña IL, Rodney R, Simons-Morton DA, Williams MA, Bazzarre T (2001) Exercise standards for testing and training: a statement for healthcare professionals from the American Heart Association. Circulation 104:1694–1740PubMedCrossRef Fletcher GF, Balady GJ, Amsterdam EA, Chaitman B, Eckel R, Fleg J, Froelicher VF, Leon AS, Piña IL, Rodney R, Simons-Morton DA, Williams MA, Bazzarre T (2001) Exercise standards for testing and training: a statement for healthcare professionals from the American Heart Association. Circulation 104:1694–1740PubMedCrossRef

go back to reference Guazzi M, Adams V, Conraads V, Halle M, Mezzani A, Vanhees L, Arena R, Fletcher GF, Forman DE, Kitzman DW, Lavie CJ, Myers J (2012) Clinical recommendations for cardiopulmonary exercise testing data assessment in specific patient populations. Circulation 126:2261–2274PubMedCrossRef Guazzi M, Adams V, Conraads V, Halle M, Mezzani A, Vanhees L, Arena R, Fletcher GF, Forman DE, Kitzman DW, Lavie CJ, Myers J (2012) Clinical recommendations for cardiopulmonary exercise testing data assessment in specific patient populations. Circulation 126:2261–2274PubMedCrossRef

go back to reference Kallistratos MS, Dritsas A, Laoutaris ID, Cokkinos DV (2007) N-terminal prohormone brain natriuretic peptide as a marker for detecting low functional class patients and candidates for cardiac transplantation: linear correlation with exercise tolerance. J Heart Lung Transplant 26:516–521PubMedCrossRef Kallistratos MS, Dritsas A, Laoutaris ID, Cokkinos DV (2007) N-terminal prohormone brain natriuretic peptide as a marker for detecting low functional class patients and candidates for cardiac transplantation: linear correlation with exercise tolerance. J Heart Lung Transplant 26:516–521PubMedCrossRef

go back to reference Katan M, Christ-Crain M (2010) The stress hormone copeptin: a new prognostic biomarker in acute illness. Swiss Med Wkly 140:w13101PubMed Katan M, Christ-Crain M (2010) The stress hormone copeptin: a new prognostic biomarker in acute illness. Swiss Med Wkly 140:w13101PubMed

go back to reference Kelly D, Squire IB, Khan SQ, Quinn P, Struck J, Morgenthaler NG, Davies JE, Ng LL (2008) C-terminal provasopressin (copeptin) is associated with left ventricular dysfunction, remodeling, and clinical heart failure in survivors of myocardial infarction. J Card Fail 14:739–745PubMedCrossRef Kelly D, Squire IB, Khan SQ, Quinn P, Struck J, Morgenthaler NG, Davies JE, Ng LL (2008) C-terminal provasopressin (copeptin) is associated with left ventricular dysfunction, remodeling, and clinical heart failure in survivors of myocardial infarction. J Card Fail 14:739–745PubMedCrossRef

go back to reference Kruger S, Graf J, Kunz D, Stickel T, Hanrath P, Janssens U (2002) Brain natriuretic peptide levels predict functional capacity in patients with chronic heart failure. J Am Coll Cardiol 40:718–722PubMedCrossRef Kruger S, Graf J, Kunz D, Stickel T, Hanrath P, Janssens U (2002) Brain natriuretic peptide levels predict functional capacity in patients with chronic heart failure. J Am Coll Cardiol 40:718–722PubMedCrossRef

go back to reference Kruger S, Ewig S, Giersdorf S, Hartmann O, Suttorp N, Welte T (2010) Cardiovascular and inflammatory biomarkers to predict short- and long-term survival in community-acquired pneumonia: results from the German Competence Network, CAPNETZ. Am J Respir Crit Care Med 182:1426–1434PubMedCrossRef Kruger S, Ewig S, Giersdorf S, Hartmann O, Suttorp N, Welte T (2010) Cardiovascular and inflammatory biomarkers to predict short- and long-term survival in community-acquired pneumonia: results from the German Competence Network, CAPNETZ. Am J Respir Crit Care Med 182:1426–1434PubMedCrossRef

go back to reference Krzeminski K, Mikulski T, Kruk B, Nazar K (2003) Plasma adrenomedullin response to maximal exercise in healthy subjects. J Physiol Pharmacol 54:225–232PubMed Krzeminski K, Mikulski T, Kruk B, Nazar K (2003) Plasma adrenomedullin response to maximal exercise in healthy subjects. J Physiol Pharmacol 54:225–232PubMed

go back to reference Lewis GD, Shah RV, Pappagianopolas PP, Systrom DM, Semigran MJ (2008) Determinants of ventilatory efficiency in heart failure: the role of right ventricular performance and pulmonary vascular tone. Circ Heart Fail 1:227–233PubMedCentralPubMedCrossRef Lewis GD, Shah RV, Pappagianopolas PP, Systrom DM, Semigran MJ (2008) Determinants of ventilatory efficiency in heart failure: the role of right ventricular performance and pulmonary vascular tone. Circ Heart Fail 1:227–233PubMedCentralPubMedCrossRef

go back to reference Maeder M, Wolber T, Rickli H, Myers J, Hack D, Riesen W, Weilenmann D, Ammann P (2007) B-type natriuretic peptide kinetics and cardiopulmonary exercise testing in heart failure. Int J Cardiol 120:391–398PubMedCrossRef Maeder M, Wolber T, Rickli H, Myers J, Hack D, Riesen W, Weilenmann D, Ammann P (2007) B-type natriuretic peptide kinetics and cardiopulmonary exercise testing in heart failure. Int J Cardiol 120:391–398PubMedCrossRef

go back to reference Maeder MT, Brutsche MH, Staub D, Morgenthaler NG, Bergmann A, Noveanu M, Laule K, Breidthardt T, Christ A, Klima T, Reichlin T, Potocki M, Mueller C (2009) B-type natriuretic peptide and C-terminal-pro-endothelin-1 for the prediction of severely impaired peak oxygen consumption. J Intern Med 265:604–615PubMedCrossRef Maeder MT, Brutsche MH, Staub D, Morgenthaler NG, Bergmann A, Noveanu M, Laule K, Breidthardt T, Christ A, Klima T, Reichlin T, Potocki M, Mueller C (2009) B-type natriuretic peptide and C-terminal-pro-endothelin-1 for the prediction of severely impaired peak oxygen consumption. J Intern Med 265:604–615PubMedCrossRef

go back to reference Maeder MT, Brutsche MH, Christ A, Staub D, Noveanu M, Breidthardt T, Schaub N, Potocki M, Reichlin T, Morgenthaler NG, Bergmann A, Mueller C (2010a) Midregional pro-A-type natriuretic peptide for the evaluation of exercise intolerance. Int J Cardiol 145:326–328PubMedCrossRef Maeder MT, Brutsche MH, Christ A, Staub D, Noveanu M, Breidthardt T, Schaub N, Potocki M, Reichlin T, Morgenthaler NG, Bergmann A, Mueller C (2010a) Midregional pro-A-type natriuretic peptide for the evaluation of exercise intolerance. Int J Cardiol 145:326–328PubMedCrossRef

go back to reference Maeder MT, Brutsche MH, Staub D, Morgenthaler NG, Bergmann A, Noveanu M, Laule K, Breidthardt T, Christ A, Klima T, Reichlin T, Potocki M, Mueller C (2010b) Copeptin response to clinical maximal exercise tests. Clin Chem 56:674–676PubMedCrossRef Maeder MT, Brutsche MH, Staub D, Morgenthaler NG, Bergmann A, Noveanu M, Laule K, Breidthardt T, Christ A, Klima T, Reichlin T, Potocki M, Mueller C (2010b) Copeptin response to clinical maximal exercise tests. Clin Chem 56:674–676PubMedCrossRef

go back to reference Maeder MT, Thompson BR, Htun N, Kaye DM (2012) Hemodynamic determinants of the abnormal cardiopulmonary exercise response in heart failure with preserved left ventricular ejection fraction. J Card Fail 18:702–710PubMedCrossRef Maeder MT, Thompson BR, Htun N, Kaye DM (2012) Hemodynamic determinants of the abnormal cardiopulmonary exercise response in heart failure with preserved left ventricular ejection fraction. J Card Fail 18:702–710PubMedCrossRef

go back to reference Maisel A, Mueller C, Nowak RM, Peacock WF, Ponikowski P, Mockel M, Hogan C, Wu AH, Richards M, Clopton P, Filippatos GS, Di Somma S, Anand I, Ng LL, Daniels LB, Neath SX, Christenson R, Potocki M, McCord J, Hartmann O, Morgenthaler NG, Anker SD (2011) Midregion prohormone adrenomedullin and prognosis in patients presenting with acute dyspnea: results from the BACH (Biomarkers in Acute Heart Failure) trial. J Am Coll Cardiol 58:1057–1067PubMedCrossRef Maisel A, Mueller C, Nowak RM, Peacock WF, Ponikowski P, Mockel M, Hogan C, Wu AH, Richards M, Clopton P, Filippatos GS, Di Somma S, Anand I, Ng LL, Daniels LB, Neath SX, Christenson R, Potocki M, McCord J, Hartmann O, Morgenthaler NG, Anker SD (2011) Midregion prohormone adrenomedullin and prognosis in patients presenting with acute dyspnea: results from the BACH (Biomarkers in Acute Heart Failure) trial. J Am Coll Cardiol 58:1057–1067PubMedCrossRef

go back to reference Morgenthaler NG, Struck J, Alonso C, Bergmann A (2005) Measurement of midregional proadrenomedullin in plasma with an immunoluminometric assay. Clin Chem 51:1823–1829PubMedCrossRef Morgenthaler NG, Struck J, Alonso C, Bergmann A (2005) Measurement of midregional proadrenomedullin in plasma with an immunoluminometric assay. Clin Chem 51:1823–1829PubMedCrossRef

go back to reference Morgenthaler NG, Struck J, Alonso C, Bergmann A (2006) Assay for the measurement of copeptin, a stable peptide derived from the precursor of vasopressin. Clin Chem 52:112–119PubMedCrossRef Morgenthaler NG, Struck J, Alonso C, Bergmann A (2006) Assay for the measurement of copeptin, a stable peptide derived from the precursor of vasopressin. Clin Chem 52:112–119PubMedCrossRef

go back to reference Morgenthaler NG, Muller B, Struck J, Bergmann A, Redl H, Christ-Crain M (2007) Copeptin, a stable peptide of the arginine vasopressin precursor, is elevated in hemorrhagic and septic shock. Shock 28:219–226PubMedCrossRef Morgenthaler NG, Muller B, Struck J, Bergmann A, Redl H, Christ-Crain M (2007) Copeptin, a stable peptide of the arginine vasopressin precursor, is elevated in hemorrhagic and septic shock. Shock 28:219–226PubMedCrossRef

go back to reference Mueller T, Gegenhuber A, Poelz W, Haltmayer M (2004) Preliminary evaluation of the AxSYM B-type natriuretic peptide (BNP) assay and comparison with the ADVIA Centaur BNP assay. Clin Chem 50:1104–1106PubMedCrossRef Mueller T, Gegenhuber A, Poelz W, Haltmayer M (2004) Preliminary evaluation of the AxSYM B-type natriuretic peptide (BNP) assay and comparison with the ADVIA Centaur BNP assay. Clin Chem 50:1104–1106PubMedCrossRef

go back to reference Mueller T, Gegenhuber A, Dieplinger B, Poelz W, Haltmayer M (2005) Capability of B-type natriuretic peptide (BNP) and amino-terminal proBNP as indicators of cardiac structural disease in asymptomatic patients with systemic arterial hypertension. Clin Chem 51(12):2245–2251PubMedCrossRef Mueller T, Gegenhuber A, Dieplinger B, Poelz W, Haltmayer M (2005) Capability of B-type natriuretic peptide (BNP) and amino-terminal proBNP as indicators of cardiac structural disease in asymptomatic patients with systemic arterial hypertension. Clin Chem 51(12):2245–2251PubMedCrossRef

go back to reference Paterson DH, Cunningham DA, Koval JJ, St Croix CM (1999). Aerobic fitness in a population of independently living men and women aged 55-86 years. Med Sci Sports Exerc 31:1813-1820 Paterson DH, Cunningham DA, Koval JJ, St Croix CM (1999). Aerobic fitness in a population of independently living men and women aged 55-86 years. Med Sci Sports Exerc 31:1813-1820

go back to reference Potocki M, Ziller R, Mueller C (2012) Mid-regional pro-adrenomedullin in acute heart failure: a better biomarker or just another biomarker? Curr Heart Fail Rep 9:244–251PubMedCrossRef Potocki M, Ziller R, Mueller C (2012) Mid-regional pro-adrenomedullin in acute heart failure: a better biomarker or just another biomarker? Curr Heart Fail Rep 9:244–251PubMedCrossRef

go back to reference Schmid A, Schilter D, Fengels I, Chhajed PN, Strobel W, Tamm M, Brutsche M (2007) Design and validation of an interpretative strategy for cardiopulmonary exercise tests. Respirology 12:916–923PubMedCrossRef Schmid A, Schilter D, Fengels I, Chhajed PN, Strobel W, Tamm M, Brutsche M (2007) Design and validation of an interpretative strategy for cardiopulmonary exercise tests. Respirology 12:916–923PubMedCrossRef

go back to reference Tanaka M, Kitamura K, Ishizaka Y, Ishiyama Y, Kato J, Kangawa K, Eto T (1995) Plasma adrenomedullin in various diseases and exercise-induced change in adrenomedullin in healthy subjects. Intern Med 34:728–733PubMedCrossRef Tanaka M, Kitamura K, Ishizaka Y, Ishiyama Y, Kato J, Kangawa K, Eto T (1995) Plasma adrenomedullin in various diseases and exercise-induced change in adrenomedullin in healthy subjects. Intern Med 34:728–733PubMedCrossRef

go back to reference Truong QA, Siegel E, Karakas M, Januzzi JL Jr, Bamberg F, Mahabadi AA, Dasdemir S, Brady TJ, Bergmann A, Kunde J, Nagurney JT, Hoffmann U, Koenig W (2010) Relation of natriuretic peptides and midregional proadrenomedullin to cardiac chamber volumes by computed tomography in patients without heart failure: from the ROMICAT Trial. Clin Chem 56:651–660PubMedCentralPubMedCrossRef Truong QA, Siegel E, Karakas M, Januzzi JL Jr, Bamberg F, Mahabadi AA, Dasdemir S, Brady TJ, Bergmann A, Kunde J, Nagurney JT, Hoffmann U, Koenig W (2010) Relation of natriuretic peptides and midregional proadrenomedullin to cardiac chamber volumes by computed tomography in patients without heart failure: from the ROMICAT Trial. Clin Chem 56:651–660PubMedCentralPubMedCrossRef

go back to reference Urwyler SA, Schuetz P, Fluri F, Morgenthaler NG, Zweifel C, Bergmann A, Bingisser R, Kappos L, Steck A, Engelter S, Muller B, Christ-Crain M, Katan M (2010) Prognostic value of copeptin: one-year outcome in patients with acute stroke. Stroke 41:1564–1567PubMedCrossRef Urwyler SA, Schuetz P, Fluri F, Morgenthaler NG, Zweifel C, Bergmann A, Bingisser R, Kappos L, Steck A, Engelter S, Muller B, Christ-Crain M, Katan M (2010) Prognostic value of copeptin: one-year outcome in patients with acute stroke. Stroke 41:1564–1567PubMedCrossRef

go back to reference von Haehling S, Filippatos GS, Papassotiriou J, Cicoira M, Jankowska EA, Doehner W, Rozentryt P, Vassanelli C, Struck J, Banasiak W, Ponikowski P, Kremastinos D, Bergmann A, Morgenthaler NG, Anker SD (2010) Mid-regional pro-adrenomedullin as a novel predictor of mortality in patients with chronic heart failure. Eur J Heart Fail 12:484–491CrossRef von Haehling S, Filippatos GS, Papassotiriou J, Cicoira M, Jankowska EA, Doehner W, Rozentryt P, Vassanelli C, Struck J, Banasiak W, Ponikowski P, Kremastinos D, Bergmann A, Morgenthaler NG, Anker SD (2010) Mid-regional pro-adrenomedullin as a novel predictor of mortality in patients with chronic heart failure. Eur J Heart Fail 12:484–491CrossRef

go back to reference von Haehling S, Papassotiriou J, Morgenthaler NG, Hartmann O, Doehner W, Stellos K, Wurster T, Schuster A, Nagel E, Gawaz M, Bigalke B (2012) Copeptin as a prognostic factor for major adverse cardiovascular events in patients with coronary artery disease. Int J Cardiol 162:27–32CrossRef von Haehling S, Papassotiriou J, Morgenthaler NG, Hartmann O, Doehner W, Stellos K, Wurster T, Schuster A, Nagel E, Gawaz M, Bigalke B (2012) Copeptin as a prognostic factor for major adverse cardiovascular events in patients with coronary artery disease. Int J Cardiol 162:27–32CrossRef

go back to reference Wild PS, Schnabel RB, Lubos E, Zeller T, Sinning CR, Keller T, Tzikas S, Lackner KJ, Peetz D, Rupprecht HJ, Bickel C, Morgenthaler NG, Papassotiriou J, Tiret L, Munzel T, Blankenberg S (2012) Midregional proadrenomedullin for prediction of cardiovascular events in coronary artery disease: results from the AtheroGene study. Clin Chem 58:226–236PubMedCrossRef Wild PS, Schnabel RB, Lubos E, Zeller T, Sinning CR, Keller T, Tzikas S, Lackner KJ, Peetz D, Rupprecht HJ, Bickel C, Morgenthaler NG, Papassotiriou J, Tiret L, Munzel T, Blankenberg S (2012) Midregional proadrenomedullin for prediction of cardiovascular events in coronary artery disease: results from the AtheroGene study. Clin Chem 58:226–236PubMedCrossRef