Skip to main content
Top
Published in: Pathology & Oncology Research 2/2008

01-06-2008 | Original Paper

Microscopic Peliosis of Pancreatic Islets Associated with Thrombotic Thrombocytopenic Purpura

Authors: Vesselin Belovejdov, Diana Staribratova, Dorian Dikov

Published in: Pathology & Oncology Research | Issue 2/2008

Login to get access

Abstract

Peliosis is a rarely seen histological finding with unexplained fully etiology and pathogenesis. It is presented as cyst-like blood filled cavities. The presence of peliosis in the endocrine part of the pancreas is extremely rarely reported microscopic phenomenon. The authors provide histological, histochemical, immunohistochemical and ultrastructural investigation of microscopic peliosis in the pancreas from an autopsy case with thrombotic trombocytopenic purpura. The findings give ideas for a wide range of pathophysiological and morphogenetic comments of such an unusual morphologic presentation.
Literature
1.
go back to reference Corpa MVN, Bacchi MM, Bacchi CE et al (2004) Peliosis hepatis associated with lymphoplasmacytic lymphoma. Arch Pathol Lab Med 128:1283–1285PubMed Corpa MVN, Bacchi MM, Bacchi CE et al (2004) Peliosis hepatis associated with lymphoplasmacytic lymphoma. Arch Pathol Lab Med 128:1283–1285PubMed
2.
go back to reference Kovacs K, Horvath E, Asa S et al (1986) Microscopic peliosis of pancreatic islets in a woman with MEN-1 syndrome. Arch Pathol Lab Med 110:607–610PubMed Kovacs K, Horvath E, Asa S et al (1986) Microscopic peliosis of pancreatic islets in a woman with MEN-1 syndrome. Arch Pathol Lab Med 110:607–610PubMed
3.
go back to reference Berzigotti A, Magalotti D, Zappoli P et al (2006) Peliosis hepatic as an early histological finding in idiopathic portal hypertension: a case report. World J Gastroenterol 12(22):3612–3615PubMed Berzigotti A, Magalotti D, Zappoli P et al (2006) Peliosis hepatic as an early histological finding in idiopathic portal hypertension: a case report. World J Gastroenterol 12(22):3612–3615PubMed
5.
go back to reference Zafrani ES, Cazier A, Baudelot AM et al (1984) Ultrastructural lesions of the liver in human peliosis. A report of 12 cases. Am J Pathol 114(3):349–359 Zafrani ES, Cazier A, Baudelot AM et al (1984) Ultrastructural lesions of the liver in human peliosis. A report of 12 cases. Am J Pathol 114(3):349–359
6.
go back to reference Warfel KA, Ellis GH (1982) Peliosis of the spleen. Report of a case and review of the literature. Arch Pathol Lab Med 106(2):99–100PubMed Warfel KA, Ellis GH (1982) Peliosis of the spleen. Report of a case and review of the literature. Arch Pathol Lab Med 106(2):99–100PubMed
7.
go back to reference Czapar CA, Weldon-Linne CM, Moore DM et al (1986) Peliosis hepatic in acquired immunodeficiency syndrome. Arch Pathol Lab Med 110(7):611–613PubMed Czapar CA, Weldon-Linne CM, Moore DM et al (1986) Peliosis hepatic in acquired immunodeficiency syndrome. Arch Pathol Lab Med 110(7):611–613PubMed
8.
go back to reference Gulubova M (2002) Immunohistochemical localization of collagen Type III and Type IV, laminin, tenascin and α-smooth muscle actin (αSMA) in the human liver in peliosis. Pathol Res Pract 198:803–812PubMedCrossRef Gulubova M (2002) Immunohistochemical localization of collagen Type III and Type IV, laminin, tenascin and α-smooth muscle actin (αSMA) in the human liver in peliosis. Pathol Res Pract 198:803–812PubMedCrossRef
9.
go back to reference Korner M, Gebbers J-O (2002) Peliosis of the spleen and haemolytic anemia. Histopathology 41:179–180PubMedCrossRef Korner M, Gebbers J-O (2002) Peliosis of the spleen and haemolytic anemia. Histopathology 41:179–180PubMedCrossRef
10.
go back to reference Koehler JE, Sanchez MA, Garrido CS et al (1997) Molecular epidemiology of Bartonellainfections in patients with bacillary angiomatosis–peliosis. The N Eng J Med 337 (26):1876–83CrossRef Koehler JE, Sanchez MA, Garrido CS et al (1997) Molecular epidemiology of Bartonellainfections in patients with bacillary angiomatosis–peliosis. The N Eng J Med 337 (26):1876–83CrossRef
11.
go back to reference Coire CI, Horvath E, Kovacs K et al (1997) Cushing’s syndrome from an ectopic pituitary adenoma with peliosis: a histological, immunohistochemical and ultrastructural study and review of the literature. Endocr Pathol 8(1):65–74PubMedCrossRef Coire CI, Horvath E, Kovacs K et al (1997) Cushing’s syndrome from an ectopic pituitary adenoma with peliosis: a histological, immunohistochemical and ultrastructural study and review of the literature. Endocr Pathol 8(1):65–74PubMedCrossRef
12.
go back to reference Lie JT (1985) Pulmonary peliosis. Arch Pathol Lab Med 109(9):878–9PubMed Lie JT (1985) Pulmonary peliosis. Arch Pathol Lab Med 109(9):878–9PubMed
13.
go back to reference Chetty R, Kennedy M, Ezzat S et al (2004) Pancreatic endocrine pathology in von Hippel-Lindau disease: an expanding spectrum of lesions. Endocrine Pathology 15(2):141–148PubMedCrossRef Chetty R, Kennedy M, Ezzat S et al (2004) Pancreatic endocrine pathology in von Hippel-Lindau disease: an expanding spectrum of lesions. Endocrine Pathology 15(2):141–148PubMedCrossRef
14.
go back to reference Pernicone PJ, Lie JT (1987) Isolated peliosis of pancreatic islet cell adenoma. Arch Pathol Lab Med 111:690–691PubMed Pernicone PJ, Lie JT (1987) Isolated peliosis of pancreatic islet cell adenoma. Arch Pathol Lab Med 111:690–691PubMed
15.
go back to reference Ricketts LM, Dlugous M, Luther KB et al (2007) O-fucosylation is require for ADAMTS 13 secretion. J Biol Chem 282(23):17014–23PubMedCrossRef Ricketts LM, Dlugous M, Luther KB et al (2007) O-fucosylation is require for ADAMTS 13 secretion. J Biol Chem 282(23):17014–23PubMedCrossRef
16.
go back to reference Girma JP (2006) Biology of von Willebrand factor. Nephrol Ther 2:s143–s148PubMed Girma JP (2006) Biology of von Willebrand factor. Nephrol Ther 2:s143–s148PubMed
17.
go back to reference Fina L, Molgaard HV, Robertson D et al (1990) Expression of the CD 34 gene in vascular endothelial cells. Blood 75 (12):2417–26PubMed Fina L, Molgaard HV, Robertson D et al (1990) Expression of the CD 34 gene in vascular endothelial cells. Blood 75 (12):2417–26PubMed
18.
go back to reference Delas N, Faurel JP, Wechsled B et al (1982) Association of peliosis and necrotizing vasculitis. Nouv Presse Med 25;11(37):2787 Delas N, Faurel JP, Wechsled B et al (1982) Association of peliosis and necrotizing vasculitis. Nouv Presse Med 25;11(37):2787
19.
go back to reference Galbusera M, Noris M, Remuzzi G (2006) Thrombotic thrombocytopenic purpura—then and now. Semin Thromb Hemost 32(2):81–89PubMedCrossRef Galbusera M, Noris M, Remuzzi G (2006) Thrombotic thrombocytopenic purpura—then and now. Semin Thromb Hemost 32(2):81–89PubMedCrossRef
20.
go back to reference Voinchet O, Degott C, Scoazec JY et al (1988) Peliosis hepatis, nodular regenerative hyperplasia of the liver, and light-chain deposition in a patient with Waldenstrom’s macroglobulinemia. Gastroenterology 95:482–486PubMed Voinchet O, Degott C, Scoazec JY et al (1988) Peliosis hepatis, nodular regenerative hyperplasia of the liver, and light-chain deposition in a patient with Waldenstrom’s macroglobulinemia. Gastroenterology 95:482–486PubMed
Metadata
Title
Microscopic Peliosis of Pancreatic Islets Associated with Thrombotic Thrombocytopenic Purpura
Authors
Vesselin Belovejdov
Diana Staribratova
Dorian Dikov
Publication date
01-06-2008
Publisher
Springer Netherlands
Published in
Pathology & Oncology Research / Issue 2/2008
Print ISSN: 1219-4956
Electronic ISSN: 1532-2807
DOI
https://doi.org/10.1007/s12253-008-9048-6

Other articles of this Issue 2/2008

Pathology & Oncology Research 2/2008 Go to the issue
Webinar | 19-02-2024 | 17:30 (CET)

Keynote webinar | Spotlight on antibody–drug conjugates in cancer

Antibody–drug conjugates (ADCs) are novel agents that have shown promise across multiple tumor types. Explore the current landscape of ADCs in breast and lung cancer with our experts, and gain insights into the mechanism of action, key clinical trials data, existing challenges, and future directions.

Dr. Véronique Diéras
Prof. Fabrice Barlesi
Developed by: Springer Medicine