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Current Osteoporosis Reports
Published in: Current Osteoporosis Reports 4/2014

01-12-2014 | Skeletal Development (E Schipani and E Zelzer, Section Editors)

microRNAs in Cartilage Development, Homeostasis, and Disease

Authors: Fatemeh Mirzamohammadi, Garyfallia Papaioannou, Tatsuya Kobayashi

Published in: Current Osteoporosis Reports | Issue 4/2014

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Abstract

microRNAs (miRNAs) regulate gene expression mainly at the posttranscriptional level. Many different miRNAs are expressed in chondrocytes, and each individual miRNA can regulate hundreds of target genes, creating a complex gene regulatory network. Experimental evidence suggests that miRNAs play significant roles in various aspects of cartilage development, homeostasis, and pathology. The possibility that miRNAs can be novel therapeutic targets for cartilage diseases led to vigorous investigations to understand the role of individual miRNAs in skeletal tissues. Here, we summarize our current understanding of miRNAs in chondrocytes and cartilage. In the first part, we discuss roles of miRNAs in growth plate development and chondrocyte differentiation. In the second part, we put a particular focus on articular cartilage and discuss the significance of variety of findings in the context of osteoarthritis, the most common degenerative joint disease.
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Metadata
Title
microRNAs in Cartilage Development, Homeostasis, and Disease
Authors
Fatemeh Mirzamohammadi
Garyfallia Papaioannou
Tatsuya Kobayashi
Publication date
01-12-2014
Publisher
Springer US
Published in
Current Osteoporosis Reports / Issue 4/2014
Print ISSN: 1544-1873
Electronic ISSN: 1544-2241
DOI
https://doi.org/10.1007/s11914-014-0229-9

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