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Current Allergy and Asthma Reports
Published in: Current Allergy and Asthma Reports 2/2014

01-02-2014 | RHINOSINUSITIS (J MULLOL, SECTION EDITOR)

MicroRNA in Chronic Rhinosinusitis and Allergic Rhinitis

Authors: Xin-Hao Zhang, Ya-Na Zhang, Zheng Liu

Published in: Current Allergy and Asthma Reports | Issue 2/2014

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Abstract

Inflammatory upper airway diseases, particularly chronic rhinosinusitis (CRS) and allergic rhinitis (AR), have a high worldwide prevalence. CRS and AR involve sustained and exaggerated inflammation that is associated with marked changes in gene and protein expression under tight regulation. A novel group of gene expression regulators is a class of short single-stranded RNA molecules termed microRNAs (miRNAs). miRNAs can cause gene silencing through degradation of target mRNAs or inhibition of translation. Dysregulated expression of miRNAs has been shown in various human diseases, such as cancer, inflammatory skin and bowel diseases, rheumatoid arthritis, and asthma. Although studies of miRNAs in inflammatory upper airway diseases are relatively new and few, emerging evidence implicates an involvement of miRNAs in shaping the inflammation pattern in upper airways. The purpose of this review is to provide an overview on our current understanding of miRNA expression and function in CRS and AR, and to underscore the potential for clinical usage of miRNAs in CRS and AR.
Literature
1.
Lagos-Quintana M, Rauhut R, Lendeckel W, Tuschl T. Identification of novel genes coding for small expressed RNAs. Science. 2001;294:853–8.PubMedCrossRef
2.
Hutvágner G, Zamore PD. A microRNA in a multiple-turnover RNAi enzyme complex. Science. 2002;297:2056–60.PubMedCrossRef
3.
4.
Berezikov E, Guryev V, van de Belt J, Wienholds E, Plasterk RH H, Cuppen E. Phylogenetic shadowing and computational identification of human microRNA genes. Cell. 2005;120:21–4.PubMedCrossRef
5.
6.
7.
Lu TX, Rothenberg ME. Diagnostic, functional, and therapeutic roles of microRNA in allergic diseases. J Allergy Clin Immunol. 2013;132:3–13.PubMedCrossRef
8.
9.
10.
Coskun M, Bjerrum JT, Seidelin JB, Nielsen OH. MicroRNAs in inflammatory bowel disease–pathogenesis, diagnostics and therapeutics. World J Gastroenterol. 2012;18:4629–34.PubMedCrossRef
11.
Long XB, Sun GB, Hu S, Liang GT, et al. Let-7a microRNA functions as a potential tumor suppressor in human laryngeal cancer. Oncol Rep. 2009;22:1189–95.PubMed
12.
13.
Mattes J, Collison A, Plank M, Phipps S, Foster PS. Antagonism of microRNA-126 suppresses the effector function of TH2 cells and the development of allergic airways disease. Proc Natl Acad Sci U S A. 2009;106:18704–9.PubMedCentralPubMedCrossRef
14.
Pandit KV, Corcoran D, Yousef H, et al. Inhibition and role of let-7d in idiopathic pulmonary fibrosis. Am J Respir Crit Care Med. 2010;182:220–9.PubMedCrossRef
15.
Sonkoly E, Janson P, Majuri ML, et al. MiR-155 is overexpressed in patients with atopic dermatitis and modulates T-cell proliferative responses by targeting cytotoxic T lymphocyte-associated antigen 4. J Allergy Clin Immunol. 2010;126:581–9.PubMedCrossRef
16.
17.
Wang H, Liu Y, Liu Z. Clara cell 10-kD protein in inflammatory upper airway diseases. Curr Opin Allergy Clin Immunol. 2013;13:25–30.PubMedCrossRef
18.
Bousquet J, Khaltaev N, Cruz AA, et al. Allergic Rhinitis and its Impact on Asthma (ARIA) 2008 update (in collaboration with the World Health Organization, GA(2)LEN and AllerGen). Allergy. 2008;63 Suppl 86:8–160.PubMedCrossRef
19.
Liu Z, Kim J, Sypek JP, et al. Gene expression profiles in human nasal polyp tissues studied by means of DNA microarray. J Allergy Clin Immunol. 2004;114:783–90.PubMedCrossRef
20.
Zhao CY, Wang X, Liu M, Jin DJ. Microarray gene analysis of Toll-like receptor signaling elements in chronic rhinosinusitis with nasal polyps. Int Arch Allergy Immunol. 2011;156:297–304.PubMedCrossRef
21.
Tewfik MA, Bossé Y, Al-Shemari H, Desrosiers MJ. Genetics of chronic rhinosinusitis: a primer. Otolaryngol Head Neck Surg. 2010;39:62–8.
22.
Chiosea S, Jelezcova E, Chandran U, Luo J, Mantha G, Sobol RW, et al. Overexpression of Dicer in precursor lesions of lung adenocarcinoma. Cancer Res. 2007;67:2345–50.PubMedCrossRef
23.
Denli AM, Tops BB, Plasterk RH, Ketting RF, Hannon GJ. Processing of primary microRNAs by the Microprocessor complex. Nature. 2004;432:231–5.PubMedCrossRef
24.
Kim VN. MicroRNA biogenesis: coordinated cropping and dicing. Nat Rev Mol Cell Biol. 2005;6:376–85.PubMedCrossRef
25.
26.
Kok KH, Ng MH, Ching YP, Jin DY. Human TRBP and PACT directly interact with each other and associate with Dicer to facilitate the production of small interfering RNA. J Biol Chem. 2007;282:17649–57.PubMedCrossRef
27.
Chendrimada TP, Gregory RI, Kumaraswamy E, et al. TRBP recruits the Dicer complex to Ago2 for microRNA processing and gene silencing. Nature. 2005;436:740–4.PubMedCentralPubMedCrossRef
28.
Haase AD, Jaskiewicz L, Zhang H, et al. TRBP, a regulator of cellular PKR and HIV-1 virus expression, interacts with Dicer and functions in RNA silencing. EMBO Rep. 2005;6:961–7.PubMedCentralPubMedCrossRef
29.••
Zhang YN, Cao PP, Zhang XH, Lu X, Liu Z. Expression of microRNA machinery proteins in different types of chronic rhinosinusitis. Laryngoscope. 2012;122:2621–7. This study reports the expression of miRNA machinery proteins in sinonasal mucosa and increased PACT expression in plasma cells in eosinophilic CRSwNP.PubMedCrossRef
30.
Lee Y, Hur I, Park SY, Kim YK, Suh MR, Kim VN. The role of PACT in the RNA silencing pathway. EMBO J. 2006;25:522–32.PubMedCrossRef
31.
Caudy AA, Myers M, Hannon GJ, Hammond SM. Fragile X-related protein and VIG associate with the RNA interference machinery. Genes Dev. 2002;16:2491–6.PubMedCrossRef
32.
Filková M, Jüngel A, Gay RE, Gay S. MicroRNAs in rheumatoid arthritis: potential role in diagnosis and therapy. BioDrugs. 2012;26:131–41.PubMedCrossRef
33.
Bandiera S, Cartault F, Jannot AS, et al. Genetic variations creating microRNA target sites in the FXN 3'-UTR affect frataxin expression in Friedreich ataxia. PLoS One. 2013;8:e54791.PubMedCentralPubMedCrossRef
34.
Ye Q, Zhao X, Xu K, et al. Polymorphisms in lipid metabolism related miRNA binding sites and risk of metabolic syndrome. Gene. 2013;528:132–8.PubMedCrossRef
35.
Fokkens WJ, Lund VJ, Mullol J, et al. European Position Paper on Rhinosinusitis and Nasal Polyps 2012. Rhinol Suppl. 2012;23:1–298.
36.
Meltzer EO, Hamilos DL, Hadley JA, et al. Rhinosinusitis: establishing definitions for clinical research and patient care. J Allergy Clin Immunol. 2004;114:S155–212.CrossRef
37.
Cao PP, Li HB, Wang BF, et al. Distinct immunopathologic characteristics of various types of chronic rhinosinusitis in adult Chinese. J Allergy Clin Immunol. 2009;124:478–84.PubMedCrossRef
38.
Van Bruaene N, Pérez-Novo CA, Basinski TM, et al. T-cell regulation in chronic paranasal sinus disease. J Allergy Clin Immunol. 2008;121:1435–41.PubMedCrossRef
39.
Van Zele T, Claeys S, Gevaert P, et al. Differentiation of chronic sinus diseases by measurement of inflammatory mediators. Allergy. 2006;61:1280–9.PubMedCrossRef
40.
Shi LL, Xiong P, Zhang L, et al. Features of airway remodeling in different types of Chinese chronic rhinosinusitis are associated with inflammation patterns. Allergy. 2013;68:101–9.PubMedCrossRef
41.••
Zhang XH, Zhang YN, Li HB, et al. Overexpression of miR-125b, a novel regulator of innate immunity, in eosinophilic chronic rhinosinusitis with nasal polyps. Am J Respir Crit Care Med. 2012;185:140–51. This study demonstrates miR-125b can promote type I INF expression through suppressing the protein expression of 4E-BP1, thus contributing to eosinophilic inflammation.PubMedCrossRef
42.
Colina R, Costa-Mattioli M, Dowling RJ, et al. Translational control of the innate immune response through IRF-7. Nature. 2008;452:323–8.PubMedCrossRef
43.
Kato A, Truong-Tran AQ, Scott AL, et al. Airway epithelial cells produce B cell-activating factor of TNF family by an IFN-beta-dependent mechanism. J Immunol. 2006;177:7164–72.PubMedCentralPubMed
44.
Kato A, Peters A, Suh L, Carter R, et al. Evidence of a role for B cell activating factor of the TNF family in the pathogenesis of chronic rhinosinusitis with nasal polyps. J Allergy Clin Immunol. 2008;121:1385–92.PubMedCentralPubMedCrossRef
45.
Liao B, Hu CY, Liu T, Liu Z. Respiratory viral infection in the chronic persistent phase of chronic rhinosinusitis. Laryngoscope. 2013. doi:10.​1002/​lary.​24348.
46.
Chiosea S, Jelezcova E, Chandran U, et al. Up-regulation of dicer, a component of the MicroRNA machinery, in prostate adenocarcinoma. Am J Pathol. 2006;169:1812–20.PubMedCrossRef
47.
Chong MM, Rasmussen JP, Rudensky AY, Littman DR. The RNaseIII enzyme Drosha is critical in T cells for preventing lethal inflammatory disease. J Exp Med. 2008;205:2005–17.PubMedCentralPubMedCrossRef
48.
Liston A, Lu LF, O’Carroll D, Tarakhovsky A, Rudensky AY. Dicer-dependent microRNA pathway safeguards regulatory T cell function. J Exp Med. 2008;205:1993–2004.PubMedCentralPubMedCrossRef
49.
Vigorito E, Perks KL, Abreu-Goodger C, et al. microRNA-155 regulates the generation of immunoglobulin class-switched plasma cells. Immunity. 2007;27:847–59.PubMedCrossRef
50.••
Shaoqing Y, Ruxin Z, Guojun L, et al. Microarray analysis of differentially expressed microRNAs in allergic rhinitis. Am J Rhinol Allergy. 2011;25:e242–6. This study compares the difference in miRNA expression profiles between AR patients and nonallergic controls.PubMedCrossRef
51.
Suojalehto H, Toskala E, Kilpeläinen M, et al. MicroRNA profiles in nasal mucosa of patients with allergic and nonallergic rhinitis and asthma. Int Forum Allergy Rhinol. 2013;3:612–20.PubMedCrossRef
52.••
Chen RF, Huang HC, Ou CY, et al. MicroRNA-21 expression in neonatal blood associated with antenatal immunoglobulin E production and development of allergic rhinitis. Clin Exp Allergy. 2010;40:1482–90. This study indicates that the regulatory association between miR-21 and TGFBR2 in AR and miR-21 could potentially be an early predictor of AR.PubMedCrossRef
53.
Salib RJ, Kumar S, Wilson SJ, Howarth PH. Nasal mucosal immunoexpression of the mast cell chemoattractants TGF-beta, eotaxin, and stem cell factor and their receptors in allergic rhinitis. J Allergy Clin Immunol. 2004;114:799–806.PubMedCrossRef
54.
Lu TX, Munitz A, Rothenberg ME. MicroRNA-21 is up-regulated in allergic airway inflammation and regulates IL-12p35 expression. J Immunol. 2009;182:4994–5002.PubMedCrossRef
55.
Li T, Leong MH, Harms B, Kennedy G, Chen L. MicroRNA-21 as a potential colon and rectal cancer biomarker. World J Gastroenterol. 2013;19:5615–21.PubMed
56.
Fendler A, Jung K. MicroRNAs as new diagnostic and prognostic biomarkers in urological tumors. Crit Rev Oncog. 2013;18:289–302.PubMedCrossRef
57.
Baxter D, McInnes IB, Kurowska-Stolarska M. Novel regulatory mechanisms in inflammatory arthritis: a role for microRNA. Immunol Cell Biol. 2012;90:288–92.PubMedCrossRef
58.
Lanford RE, Hildebrandt-Eriksen ES, Petri A, et al. Therapeutic silencing of microRNA-122 in primates with chronic hepatitis C virus infection. Science. 2010;327:198–201.PubMedCentralPubMedCrossRef
59.
Collison A, Mattes J, Plank M, Foster PS. Inhibition of house dust mite-induced allergic airways disease by antagonism of microRNA-145 is comparable to glucocorticoid treatment. J Allergy Clin Immunol. 2011;128:160–7.PubMedCrossRef
60.
Sharma A, Kumar M, Ahmad T, et al. Antagonism of mmu-mir-106a attenuates asthma features in allergic murine model. J Appl Physiol (1985). 2012;113:459–64.CrossRef
Metadata
Title
MicroRNA in Chronic Rhinosinusitis and Allergic Rhinitis
Authors
Xin-Hao Zhang
Ya-Na Zhang
Zheng Liu
Publication date
01-02-2014
Publisher
Springer US
Published in
Current Allergy and Asthma Reports / Issue 2/2014
Print ISSN: 1529-7322
Electronic ISSN: 1534-6315
DOI
https://doi.org/10.1007/s11882-013-0415-3

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