Top

Published in:

Open Access 01-12-2014 | Review

MicroRNA-binding site polymorphisms in hematological malignancies

Author: Agnieszka Dzikiewicz-Krawczyk

Published in: Journal of Hematology & Oncology | Issue 1/2014

Abstract

Dysregulation of microRNA networks has been implicated in hematological malignancies. One of the reasons for disturbed miRNA-mediated regulation are polymorphisms in miRNA-binding sites (miRSNPs), which alter the strength of miRNA interaction with target transcripts. In the recent years the first findings of miRSNPs associated with risk and prognosis in hematological malignancies have been reported. From the studies described in this review miRSNPs not only emerge as novel markers of risk and prognosis but can also lead to better understanding of the role of miRNAs in regulating gene expression in health and disease.

Available only for authorised users

Bartel DP: MicroRNAs: target recognition and regulatory functions. Cell. 2009, 136: 215-233. 10.1016/j.cell.2009.01.002.PubMedCentralCrossRefPubMed

Kozomara A, Griffiths-Jones S: miRBase: annotating high confidence microRNAs using deep sequencing data. Nucleic Acids Res. 2014, 42: D68-73. 10.1093/nar/gkt1181.PubMedCentralCrossRefPubMed

Friedman RC, Farh KK, Burge CB, Bartel DP: Most mammalian mRNAs are conserved targets of microRNAs. Genome Res. 2009, 19: 92-105. 10.1101/gr.082701.108.PubMedCentralCrossRefPubMed

Bartel DP: MicroRNAs: genomics, biogenesis, mechanism, and function. Cell. 2004, 116: 281-297. 10.1016/S0092-8674(04)00045-5.CrossRefPubMed

Lawrie CH: MicroRNAs in hematological malignancies. Blood Rev. 2013, 27: 143-154. 10.1016/j.blre.2013.04.002.CrossRefPubMed

Kluiver J, Kroesen BJ, Poppema S, van den Berg A: The role of microRNAs in normal hematopoiesis and hematopoietic malignancies. Leukemia. 2006, 20: 1931-1936. 10.1038/sj.leu.2404387.CrossRefPubMed

Witkos TM, Koscianska E, Krzyzosiak WJ: Practical Aspects of microRNA Target Prediction. Curr Mol Med. 2011, 11: 93-109. 10.2174/156652411794859250.PubMedCentralCrossRefPubMed

Chen K, Rajewsky N: Natural selection on human microRNA binding sites inferred from SNP data. Nat Genet. 2006, 38: 1452-1456. 10.1038/ng1910.CrossRefPubMed

Yu Z, Li Z, Jolicoeur N, Zhang L, Fortin Y, Wang E, Wu M, Shen SH: Aberrant allele frequencies of the SNPs located in microRNA target sites are potentially associated with human cancers. Nucleic Acids Res. 2007, 35: 4535-4541. 10.1093/nar/gkm480.PubMedCentralCrossRefPubMed

10.

Saunders MA, Liang H, Li WH: Human polymorphism at microRNAs and microRNA target sites. Proc Natl Acad Sci U S A. 2007, 104: 3300-3305. 10.1073/pnas.0611347104.PubMedCentralCrossRefPubMed

11.

Salzman DW, Weidhaas JB: SNPing cancer in the bud: microRNA and microRNA-target site polymorphisms as diagnostic and prognostic biomarkers in cancer. Pharmacol Ther. 2013, 137: 55-63. 10.1016/j.pharmthera.2012.08.016.PubMedCentralCrossRefPubMed

12.

Mishra PJ, Bertino JR: MicroRNA polymorphisms: the future of pharmacogenomics, molecular epidemiology and individualized medicine. Pharmacogenomics. 2009, 10: 399-416. 10.2217/14622416.10.3.399.PubMedCentralCrossRefPubMed

13.

de Larrea CF, Navarro A, Tejero R, Tovar N, Díaz T, Cibeira MT, Rosiñol L, Ferrer G, Rovira M, Rozman M, Monzó M, Bladé J: Impact of MiRSNPs on survival and progression in patients with multiple myeloma undergoing autologous stem cell transplantation. Clin Cancer Res. 2012, 18: 3697-3704. 10.1158/1078-0432.CCR-12-0191.CrossRefPubMed

14.

Karantza V: Keratins in health and cancer: more than mere epithelial cell markers. Oncogene. 2011, 30: 127-138. 10.1038/onc.2010.456.PubMedCentralCrossRefPubMed

15.

Navarro A, Muñoz C, Gaya A, Díaz-Beyá M, Gel B, Tejero R, Díaz T, Martinez A, Monzó M: MiR-SNPs as markers of toxicity and clinical outcome in Hodgkin lymphoma patients. PLoS One. 2013, 8: e64716-10.1371/journal.pone.0064716.PubMedCentralCrossRefPubMed

16.

Xie Y, Diao L, Zhang L, Liu C, Xu Z, Liu S: A miR-SNP of the KRT81 gene is associated with the prognosis of non-Hodgkin's lymphoma. Gene. 2014, 539: 198-202. 10.1016/j.gene.2014.02.010.CrossRefPubMed

17.

Melo SA, Esteller M: Disruption of microRNA nuclear transport in human cancer. Semin Cancer Biol. 2014, 27C: 46-51. 10.1016/j.semcancer.2014.02.012.CrossRef

18.

Li Y, Gordon MW, Xu-Monette ZY, Visco C, Tzankov A, Zou D, Qiu L, Montes-Moreno S, Dybkaer K, Orazi A, Zu Y, Bhagat G, Richards KL, Hsi ED, Choi WW, van Krieken JH, Huang Q, Ai W, Ponzoni M, Ferreri AJ, Winter JN, Go RS, Piris MA, Møller MB, Wu L, Wang M, Ramos KS, Medeiros LJ, Young KH: Single nucleotide variation in the TP53 3' untranslated region in diffuse large B-cell lymphoma treated with rituximab-CHOP: a report from the International DLBCL Rituximab-CHOP Consortium Program. Blood. 2013, 121: 4529-4540. 10.1182/blood-2012-12-471722.PubMedCentralCrossRefPubMed

19.

Yang B, Liu C, Diao L, Wang C, Guo Z: A polymorphism at the microRNA binding site in the 3' untranslated region of C14orf101 is associated with non-Hodgkin lymphoma overall survival. Cancer Genet. 2014, 207: 141-146. 10.1016/j.cancergen.2014.03.007.CrossRefPubMed

20.

Falini B, Martelli MP, Bolli N, Sportoletti P, Liso A, Tiacci E, Haferlach T: Acute myeloid leukemia with mutated nucleophosmin (NPM1): is it a distinct entity?. Blood. 2011, 117: 1109-1120. 10.1182/blood-2010-08-299990.CrossRefPubMed

21.

Cheng CK, Kwan TK, Cheung CY, Ng K, Liang P, Cheng SH, Chan NP, Ip RK, Wong RS, Lee V, Li CK, Yip SF, Ng MH: A polymorphism in the 3'-untranslated region of the NPM1 gene causes illegitimate regulation by microRNA-337-5p and correlates with adverse outcome in acute myeloid leukemia. Haematologica. 2013, 98: 913-917. 10.3324/haematol.2012.073015.PubMedCentralCrossRefPubMed

22.

Dzikiewicz-Krawczyk A, Macieja A, Mały E, Januszkiewicz-Lewandowska D, Mosor M, Fichna M, Strauss E, Nowak J: Polymorphisms in microRNA target sites modulate risk of lymphoblastic and myeloid leukemias and affect microRNA binding. J Hematol Oncol. 2014, 7: 43-10.1186/1756-8722-7-43.PubMedCentralCrossRefPubMed

23.

Salmena L, Poliseno L, Tay Y, Kats L, Pandolfi PP: A ceRNA hypothesis: the Rosetta Stone of a hidden RNA language?. Cell. 2011, 146: 353-358. 10.1016/j.cell.2011.07.014.PubMedCentralCrossRefPubMed

24.

John B, Enright AJ, Aravin A, Tuschl T, Sander C, Marks DS: Human MicroRNA targets. PLoS Biol. 2004, 2: e363-10.1371/journal.pbio.0020363.PubMedCentralCrossRefPubMed

25.

Kertesz M, Iovino N, Unnerstall U, Gaul U, Segal E: The role of site accessibility in microRNA target recognition. Nat Genet. 2007, 39: 1278-1284. 10.1038/ng2135.CrossRefPubMed

26.

Bao L, Zhou M, Wu L, Lu L, Goldowitz D, Williams RW, Cui Y: PolymiRTS Database: linking polymorphisms in microRNA target sites with complex traits. Nucleic Acids Res. 2007, 35: D51-54. 10.1093/nar/gkl797.PubMedCentralCrossRefPubMed

27.

Xu Z, Taylor JA: SNPinfo: integrating GWAS and candidate gene information into functional SNP selection for genetic association studies. Nucleic Acids Res. 2009, 37: W600-605. 10.1093/nar/gkp290.PubMedCentralCrossRefPubMed

28.

Ritchie W, Flamant S, Rasko JE: mimiRNA: a microRNA expression profiler and classification resource designed to identify functional correlations between microRNAs and their targets. Bioinformatics. 2010, 26: 223-227. 10.1093/bioinformatics/btp649.CrossRefPubMed

29.

ncRNA body map [ ], [http://www.mirnabodymap.org/]

Title: MicroRNA-binding site polymorphisms in hematological malignancies
Author: Agnieszka Dzikiewicz-Krawczyk
Publication date: 01-12-2014
Publisher: BioMed Central
Published in: Journal of Hematology & Oncology / Issue 1/2014
Electronic ISSN: 1756-8722
DOI: https://doi.org/10.1186/s13045-014-0083-3

Webinar | 19-02-2024 | 17:30 (CET)

Keynote webinar | Spotlight on antibody–drug conjugates in cancer

Watch now

Antibody–drug conjugates (ADCs) are novel agents that have shown promise across multiple tumor types. Explore the current landscape of ADCs in breast and lung cancer with our experts, and gain insights into the mechanism of action, key clinical trials data, existing challenges, and future directions.

Dr. Véronique Diéras

Prof. Fabrice Barlesi

Developed by: Springer Medicine

At a glance: The STEP trials

Springer Medicine

Abstract

Please log in to get access to this content

Other articles of this Issue 1/2014

A novel mycobacterial Hsp70-containing fusion protein targeting mesothelin augments antitumor immunity and prolongs survival in murine models of ovarian cancer and mesothelioma

Long-term results of a phase II study with neoadjuvant docetaxel chemotherapy and complete androgen blockade in locally advanced and high-risk prostate cancer

The addition of rituximab to CHOP therapy alters the prognostic significance of CD44 expression

Synergistic effects of combined platelet-activating factor receptor and epidermal growth factor receptor targeting in ovarian cancer cells

Next generation sequencing analysis of platinum refractory advanced germ cell tumor sensitive to Sunitinib (Sutent®) a VEGFR2/PDGFRβ/c-kit/ FLT3/RET/CSF1R inhibitor in a phase II trial

Developing aptamer probes for acute myelogenous leukemia detection and surface protein biomarker discovery

Keynote webinar | Spotlight on antibody–drug conjugates in cancer