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Published in: Rheumatology International 5/2014

01-05-2014 | Letter to the Editors

MicroRNA-323-3p: a new biomarker and potential therapeutic target for rheumatoid arthritis

Authors: Tao Xu, Cheng Huang, Zhaolin Chen, Jun Li

Published in: Rheumatology International | Issue 5/2014

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Abstract

Increased expression of microRNA-323-3p (miR-323-3p) has been demonstrated in rheumatoid arthritis synovial fibroblast. The gene encoding miR-323-3p, which is a biomarker in immune and inflammatory responses, occurs in an miRNA cluster in chromosomal region 14q32.31.
Literature
2.
go back to reference Pandis I, Ospelt C, Karagianni N, Denis MC, Reczko M, Camps C, Hatzigeorgiou AG, Ragoussis J, Gay S, Kollias G (2012) Identification of microRNA-221/222 and microRNA-323-3p association with rheumatoid arthritis via predictions using the human tumour necrosis factor transgenic mouse model. Ann Rheum Dis 71(10):1716–1723. doi:10.1136/annrheumdis-2011-200803 PubMedCrossRef Pandis I, Ospelt C, Karagianni N, Denis MC, Reczko M, Camps C, Hatzigeorgiou AG, Ragoussis J, Gay S, Kollias G (2012) Identification of microRNA-221/222 and microRNA-323-3p association with rheumatoid arthritis via predictions using the human tumour necrosis factor transgenic mouse model. Ann Rheum Dis 71(10):1716–1723. doi:10.​1136/​annrheumdis-2011-200803 PubMedCrossRef
4.
go back to reference de Rooy DP, Yeremenko NG, Wilson AG, Knevel R, Lindqvist E, Saxne T, Krabben A, Leijsma MK, Daha NA, Tsonaka S, Zhernakova A, Houwing-Duistermaat JJ, Huizinga TW, Toes RE, Baeten DL, Brouwer E, van der Helm-van Mil AH (2013) Genetic studies on components of the Wnt signalling pathway and the severity of joint destruction in rheumatoid arthritis. Ann Rheum Dis 72(5):769–775. doi:10.1136/annrheumdis-2012-202184 PubMedCrossRef de Rooy DP, Yeremenko NG, Wilson AG, Knevel R, Lindqvist E, Saxne T, Krabben A, Leijsma MK, Daha NA, Tsonaka S, Zhernakova A, Houwing-Duistermaat JJ, Huizinga TW, Toes RE, Baeten DL, Brouwer E, van der Helm-van Mil AH (2013) Genetic studies on components of the Wnt signalling pathway and the severity of joint destruction in rheumatoid arthritis. Ann Rheum Dis 72(5):769–775. doi:10.​1136/​annrheumdis-2012-202184 PubMedCrossRef
7.
go back to reference Nakasa T, Shibuya H, Nagata Y, Niimoto T, Ochi M (2011) The inhibitory effect of microRNA-146a expression on bone destruction in collagen-induced arthritis. Arthritis Rheum 63(6):1582–1590. doi:10.1002/art.30321 PubMedCrossRef Nakasa T, Shibuya H, Nagata Y, Niimoto T, Ochi M (2011) The inhibitory effect of microRNA-146a expression on bone destruction in collagen-induced arthritis. Arthritis Rheum 63(6):1582–1590. doi:10.​1002/​art.​30321 PubMedCrossRef
Metadata
Title
MicroRNA-323-3p: a new biomarker and potential therapeutic target for rheumatoid arthritis
Authors
Tao Xu
Cheng Huang
Zhaolin Chen
Jun Li
Publication date
01-05-2014
Publisher
Springer Berlin Heidelberg
Published in
Rheumatology International / Issue 5/2014
Print ISSN: 0172-8172
Electronic ISSN: 1437-160X
DOI
https://doi.org/10.1007/s00296-013-2767-3

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