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Tumor Biology
Published in: Tumor Biology 9/2015

01-09-2015 | Review

MicroRNA-224: as a potential target for miR-based therapy of cancer

Authors: Wei Chen, Xue-mei Fan, Ling Mao, Jun-ying Zhang, Jian LI, Jian-zhong Wu, Jin-hai Tang

Published in: Tumor Biology | Issue 9/2015

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Abstract

MicroRNAs (miRNAs) are small noncoding RNA molecules which regulate the target gene expression posttranscriptionally. Increasing studies have shown that microRNAs play important roles in multiple biological pathways. For instance, aberrant expression of microRNA-224 (miR-224) plays a vital role in tumor biology in various types of human cancer. Here, we aim to summarize the molecular mechanisms that lead to the overexpression of miR-224 in cancers, analyze the effect of miR-224 on tumor biology, and reveal the clinical significance of miR-224. MiR-224 regulates its targets by modulating messenger RNA (mRNA) stability and/or protein translation, and it would provide new insight into molecular targeting cancer treatment.
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Metadata
Title
MicroRNA-224: as a potential target for miR-based therapy of cancer
Authors
Wei Chen
Xue-mei Fan
Ling Mao
Jun-ying Zhang
Jian LI
Jian-zhong Wu
Jin-hai Tang
Publication date
01-09-2015
Publisher
Springer Netherlands
Published in
Tumor Biology / Issue 9/2015
Print ISSN: 1010-4283
Electronic ISSN: 1423-0380
DOI
https://doi.org/10.1007/s13277-015-3883-3

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