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Open Access 01-05-2014 | Original Article

Micronucleus frequency among Iraqi thyroid disorder patients

Authors: Abdul Hussein Moyet AlFaisal, Intesar Jawad Kahdoom AL-Ramahi, Ismail Abdul Redah Abdul-Hassan

Published in: Comparative Clinical Pathology | Issue 3/2014

Abstract

Micronucleus (MN) assay has been extensively used in detection of DNA damage, instability in cancer, and genetic disorders. In the current study, MN, binucleated cells, and nuclear division index (NDI) were investigated in Iraqi patients with thyroid disorders. The results indicated significantly (p < 0.05) increased binucleated cells with micronucleus (BNMN) frequencies in thyroid cancer group (37.58 ± 3.07) versus other thyroid disorder groups (6.60 ± 1.29, 14.90 ± 1.69, 15.56 ± 1.76). On the other hand, the frequency of micronucleus per 1,000 and the NDI were significantly (p < 0.05) decreased in hypothyroidism (MN 1.55 ± 0.36) (NDI 0.009 ± 0.001) versus other thyroid disorder groups (MN: 6.05 ± 0.97, 6.09 ± 0.53, 5.34 ± 0.56) (NDI: 0.049 ± 0.003, 0.032 ± 0.002, 0.025 ± 0.002), with no difference versus healthy group (0.0 ± 0.0). The number of BNMN and MN are parallel to the severity of thyroid disorders which were 6.60 ± 1.29, 14.90 ± 1.69, 15.56 ± 1.76, and 37.58 ± 3.07 for hypothyroidism, thyroid toxic goiter, thyroid nontoxic goiter, and thyroid cancer, respectively. The number of BNMN and MN are parallel to the severity of thyroid disorders which were 6.60 ± 1.29, 14.90 ± 1.69, 15.56 ± 1.76, and 37.58 ± 3.07 for hypothyroidism, thyroid toxic goiter, thyroid nontoxic goiter, and thyroid cancer, respectively. The results also indicate that there were no significant differences among age and sex groups as related with BNMN formation within each thyroid disorder groups and healthy control group.

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Title: Micronucleus frequency among Iraqi thyroid disorder patients
Authors: Abdul Hussein Moyet AlFaisal
Intesar Jawad Kahdoom AL-Ramahi
Ismail Abdul Redah Abdul-Hassan
Publication date: 01-05-2014
Publisher: Springer London
Published in: Comparative Clinical Pathology / Issue 3/2014
Print ISSN: 1618-5641
Electronic ISSN: 1618-565X
DOI: https://doi.org/10.1007/s00580-012-1671-7

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Micronucleus frequency among Iraqi thyroid disorder patients

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