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01-05-2012 | Original Communication

Microcirculation response to local cooling in patients with Huntington’s disease

Authors: Ziva Melik, Jan Kobal, Ksenija Cankar, Martin Strucl

Published in: Journal of Neurology | Issue 5/2012

Abstract

Altered autonomic nervous system (ANS) functioning in early stages of Huntington’s disease (HD) has been suggested, presumably due to distorted high-order autonomic control. ANS functioning in the early stages of HD was further investigated. Laser-Doppler (LD) flux in the skin of the fingertips, heart rate (HR), HR variability, systolic and diastolic blood pressure were measured during rest and during a 6 min cooling of one hand at 15°C. Data of 15 presymptomatic gene mutation carriers (PHD), 15 early symptomatic HD patients (EHD), and two groups of 15 age- and sex-matched controls were compared. The area under the low frequency (LF) and high frequency (HF) bands of the HR variability spectrum were calculated. An augmented reduction of cutaneous LD flux was found in response to the direct cooling in the PHD group (37.5 ± 8.5% of resting value) compared to the PHD controls (67.27 ± 8.4%) (p < 0.05). In addition, the PHD group had higher (LF/(LF + HF) index of primary sympathetic modulation of the HR at rest (53.6 ± 3.3) compared to the EHD patients (39.7 ± 4.2) (p < 0.05). In the EHD group, a significantly smaller change of HR during cooling (100.26 ± 1.2%) was found compared to the EHD controls (95.9 ± 1.0%) (p < 0.05). The results are in line with the hypothesis that ANS dysfunction occurs even in PHD subjects. Further, they support the hypothesis that dysfunction of the high-order autonomic centres are involved in HD.

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Title: Microcirculation response to local cooling in patients with Huntington’s disease
Authors: Ziva Melik
Jan Kobal
Ksenija Cankar
Martin Strucl
Publication date: 01-05-2012
Publisher: Springer-Verlag
Published in: Journal of Neurology / Issue 5/2012
Print ISSN: 0340-5354
Electronic ISSN: 1432-1459
DOI: https://doi.org/10.1007/s00415-011-6279-3

At a glance: The STEP trials

Springer Medicine

Microcirculation response to local cooling in patients with Huntington’s disease

Abstract

At a glance: The STEP trials

Springer Medicine

Abstract

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