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Breast Cancer Research
Published in: Breast Cancer Research 2/2005

01-06-2005 | Poster Presentation

Microcell-mediated transfer of chromosome 6 into the breast cancer cell line MDA-MB-231: a specific set of genes is involved in the reversion of the tumorigenic phenotype

Authors: J Strissel, S Seitz, W Arnold, J Weimer, A Jacobsen, N Arnold, S Scherneck

Published in: Breast Cancer Research | Special Issue 2/2005

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Excerpt

Several cytogenetic studies demonstrated frequent allelic losses at defined regions on chromosome 6 in breast tumors, suggesting the presence of tumor suppressor gene(s) (TSG) contributing to breast cancer (BC) tumorigenesis. Different techniques identified several candidate TSGs on chromosome 6 in BC, but no functional evidence for a TSG function for these genes could so far be supplied. In order to identify key genes and elucidate the regulatory pathways that are involved in the development and progression of BC, we combined array-based expression profiling with a powerful functional approach, the microcell-mediated chromosome transfer. …
Metadata
Title
Microcell-mediated transfer of chromosome 6 into the breast cancer cell line MDA-MB-231: a specific set of genes is involved in the reversion of the tumorigenic phenotype
Authors
J Strissel
S Seitz
W Arnold
J Weimer
A Jacobsen
N Arnold
S Scherneck
Publication date
01-06-2005
Publisher
BioMed Central
Published in
Breast Cancer Research / Issue Special Issue 2/2005
Electronic ISSN: 1465-542X
DOI
https://doi.org/10.1186/bcr1144

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