Published in:
01-05-2004 | Aids Drug Profile
Micafungin
A Viewpoint by Raj Chopra
Author:
Raj Chopra
Published in:
Drugs
|
Issue 9/2004
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Excerpt
Micafungin is a novel antifungal agent that exhibits activity against β-(1,3)-D-glycan synthase found in the fungal wall. This specific antifungal activity should theoretically at least, result in limited adverse effects and this is confirmed by the favourable tolerability profile. In vitro, the drug shows activity against Candida spp. and Aspergillus spp., but does not have activity against dimorphic fungi such as Cryptococcus spp. In particular, in vitro, there is no evidence of antagonism when micafungin is combined with other antifungal agents including amphotericin B. …