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Critical Care
Published in: Critical Care 5/2012

01-10-2012 | Commentary

Metformin overdose: time to move on

Authors: Jean-Christophe Orban, Eric Fontaine, Carole Ichai

Published in: Critical Care | Issue 5/2012

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Abstract

Does metformin-associated lactic acidosis really exist? Despite an old controversy, there is no doubt about it. But do we understand what is going on? Laboratory findings raised several hypotheses explaining the pathophysiology of this disease. The main cause could be an inhibition of either gluconeogenesis or mitochondrial respiratory chain complex I. From bench to bedside, one hypothesis is now confirmed in humans. Metformin poisoning involves, at least partially, a mitochondrial dysfunction.
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Metadata
Title
Metformin overdose: time to move on
Authors
Jean-Christophe Orban
Eric Fontaine
Carole Ichai
Publication date
01-10-2012
Publisher
BioMed Central
Published in
Critical Care / Issue 5/2012
Electronic ISSN: 1364-8535
DOI
https://doi.org/10.1186/cc11664

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