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Virchows Archiv
Published in: Virchows Archiv 5/2009

Open Access 01-11-2009 | Case Report

Metastatic potential of an aneurysmal bone cyst

Authors: Addy C. M. van de Luijtgaarden, Rene P. H. Veth, Piet J. Slootweg, Pauline M. Wijers-Koster, Leo J. Schultze Kool, Judith V. M. G. Bovee, Winette T. A. van der Graaf

Published in: Virchows Archiv | Issue 5/2009

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Abstract

Aneurysmal bone cysts (ABCs) are benign bone tumors consisting of blood-filled cavities lined by connective tissue septa. Recently, the hypothesis that ABCs are lesions reactive to local hemodynamics has been challenged after the discovery of specific recurrent chromosomal abnormalities. Multiple cases of malignant transformation of ABC into (osteo)sarcoma have been described, as well as a number of cases of telangiectatic osteosarcoma which had been misdiagnosed as ABC. We herewith document a case of a pelvic ABC metastatic to the lung, liver, and kidneys. Diagnosis was confirmed by the presence of a break in the USP6 gene, which is pathognomonic for ABC, in a pulmonary metastasis of our patient. Sarcomatous transformation as an explanation for this behavior was ruled out by demonstrating diploid DNA content in both the pulmonary lesion and the primary tumor.
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Metadata
Title
Metastatic potential of an aneurysmal bone cyst
Authors
Addy C. M. van de Luijtgaarden
Rene P. H. Veth
Piet J. Slootweg
Pauline M. Wijers-Koster
Leo J. Schultze Kool
Judith V. M. G. Bovee
Winette T. A. van der Graaf
Publication date
01-11-2009
Publisher
Springer-Verlag
Published in
Virchows Archiv / Issue 5/2009
Print ISSN: 0945-6317
Electronic ISSN: 1432-2307
DOI
https://doi.org/10.1007/s00428-009-0845-4

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