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European Archives of Oto-Rhino-Laryngology

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01-06-2020 | Metastasis | Head and Neck

Poorly differentiated thyroid carcinoma (PDTC) characteristics and the efficacy of radioactive iodine (RAI) therapy as an adjuvant treatment in a tertiary cancer care center

Authors: Shivakumar Thiagarajan, Aamir Yousuf, Ratan Shetty, Harsh Dhar, Yash Mathur, Deepa Nair, Sandeep Basu, Asawari Patil, Shubadha Kane, Sarbani Ghosh-Laskar, Devendra Chaukar

Published in: European Archives of Oto-Rhino-Laryngology | Issue 6/2020

Abstract

Background

Poorly differentiated thyroid cancer (PDTC) is biologically more aggressive. Surgery remains the mainstay of treatment. The utility of radioactive iodine (RAI) after surgery is unclear.

Methods

In this retrospective study, patients treated between Jan 2012 and Dec 2017 were included. The demographic, clinical and treatment-related details, including RAI ablation, were recorded and their survival analyzed.

Results

Thirty-five patients fulfilled the eligibility criteria. Majority was treatment naïve at presentation. All patients underwent surgery followed by RAI ablation, with a cumulative median dose of 220 mCi (range 40–1140). Sixteen patients received more than one radioiodine treatment for distant metastases. Incomplete resection, age > 45 years and the presence of distant metastasis influenced survival the most. The 3-year PFS of patients with PDTC was 69%.

Conclusion

All patients in our series showed uptake and responded to treatment. Further use of molecular markers and functional molecular imaging would better our understanding of this entity.

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Title: Poorly differentiated thyroid carcinoma (PDTC) characteristics and the efficacy of radioactive iodine (RAI) therapy as an adjuvant treatment in a tertiary cancer care center
Authors: Shivakumar Thiagarajan
Aamir Yousuf
Ratan Shetty
Harsh Dhar
Yash Mathur
Deepa Nair
Sandeep Basu
Asawari Patil
Shubadha Kane
Sarbani Ghosh-Laskar
Devendra Chaukar
Publication date: 01-06-2020
Publisher: Springer Berlin Heidelberg
Keywords: Metastasis
Thyroid Cancer
Thyroid Cancer
Thyroid Cancer
Published in: European Archives of Oto-Rhino-Laryngology / Issue 6/2020
Print ISSN: 0937-4477
Electronic ISSN: 1434-4726
DOI: https://doi.org/10.1007/s00405-020-05898-9

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Poorly differentiated thyroid carcinoma (PDTC) characteristics and the efficacy of radioactive iodine (RAI) therapy as an adjuvant treatment in a tertiary cancer care center

Abstract

Background

Methods

Results

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Methods

Results

Conclusion

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